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Your search keyword '"Wojciech Wasowicz"' showing total 5 results
Start Over Author "Wojciech Wasowicz" Journal scandinavian journal of work, environment & health
5 results on '"Wojciech Wasowicz"'

1. Dysregulation of markers of oxidative stress and DNA damage among nail technicians despite low exposure to volatile organic compounds

Author

Peter Grešner, Maciej Stepnik, Magdalena Beata Król, Radoslaw Swiercz, Anna Smok-Pieniazek, Ewa Twardowska, Jolanta Gromadzińska, and Wojciech Wasowicz

Subjects
occupational exposure, exposure, dna damage, biomarker, volatile organic compound, dna, dysregulation, marker of oxidative stress, nail technician, voc, Public aspects of medicine, RA1-1270
Abstract

OBJECTIVE: The study aimed to compare levels of selected biomarkers of oxidative stress and DNA damage and their correlation with occupational exposure to volatile organic compounds (VOC) among female nail technicians and a group of unexposed volunteers. METHODS: A panel of biomarkers of oxidative stress and DNA damage was assayed among 145 female nail technicians and 152 healthy female volunteers. Occupational exposure of nail technicians to VOC was assessed analyzing the VOC content in nail salon air samples. RESULTS: The level of occupational exposure of nail technicians to VOC was below the respective threshold limit values with combined airborne exposure to a mixture of VOC, reaching only 3.3% (range 0.2–33.3%) of the threshold limit. Despite that, nail technicians presented increased activity of glutathione peroxidase 1 (GPx1), plasma ceruloplasmin, and the GPx1/superoxide dismutase 1 ratio (P

Published
2015
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2. Rotating night shift work and polymorphism of genes important for the regulation of circadian rhythm

Author

Edyta Reszka, Beata Peplonska, Edyta Wieczorek, Wojciech Sobala, Agnieszka Bukowska, Jolanta Gromadzińska, Jenny-Anne Lie, Helge Kjuus, and Wojciech Wasowicz

Subjects
night work, circadian rhythm, nurse, shift worker, rotating shift, chronotype, night shift work, gene, cancer, sleep, polymorphism, shift work, Public aspects of medicine, RA1-1270
Abstract

OBJECTIVE: People living in industrialized societies have developed specific working schedules during the day and at night, including permanent night shifts and rotating night shifts. The aim of this study was to examine the association between circadian polymorphisms and rotating night shift work. METHODS: This cross-sectional study comprised 709 nurses and midwives (348 current rotating and 361 current day workers). Genetic polymorphism of selected clock genes BMAL1 (rs2279287), CLOCK (rs1801260), PER1 (rs2735611), PER2 (rs2304672), PER3 (rs10462020), CRY1 (rs8192440), CRY2 (rs10838527, rs10838527) was determined using real-time polymerase chain reaction (PCR) assays. RESULTS: There were no differences in BMAL1, CLOCK, CRY2, PER1, PER2, and PER3 genotypes among nurses and midwives working rotating night and day shifts. The frequency of women with rare CRY1 TT genotype was higher in the group of rotating night shift than day workers (17.0% versus 13.9%, P=0.06). Moreover, CRY1 TT genotype was associated with the total rotating shift-work duration, compared to women rarely working night shifts. CONCLUSIONS: These results suggest that CRY1 (rs8192440) polymorphism may influence the adaptation to the rotating night shift work among nurses and midwives.

Published
2013
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3. Circadian gene expression in peripheral blood leukocytes of rotating night shift nurses

Author

Edyta Reszka, Beata Peplonska, Edyta Wieczorek, Wojciech Sobala, Agnieszka Bukowska, Jolanta Gromadzińska, Jenny-Anne Lie, Helge Kjuus, and Wojciech Wasowicz

Subjects
gene, circadian gene expression, leukocycte, cancer, sleep, shift work, night work, nurse, shift worker, night shift, chronotype, Public aspects of medicine, RA1-1270
Abstract

OBJECTIVE: It has been hypothesized that the underlying mechanism of elevated breast cancer risk among long-term, night-working women involves circadian genes expression alteration caused by exposure to light at night and/or irregular work hours. The aim of the present study was to determine the effect of rotating night shift work on expression of selected core circadian genes. METHODS: The cross-sectional study was conducted on 184 matched nurses and midwives, who currently work either day or rotating night shifts, to determine the effect of irregular work at night on circadian gene expression in peripheral blood leukocytes. Transcript levels of BMAL1, CLOCK, CRY1, CRY2, PER1, PER2, and PER3 were determined by means of quantitative real-time polymerase chain reaction (PCR). RESULTS: After adjusting for hour of blood collection, there were no statistically significant changes of investigated circadian genes among nurses and midwives currently working rotating night shifts compared to nurses working day shifts. The highest expression of PER1 messanger ribonucleic acid (mRNA) was observed for women currently working shifts who had worked >15 years in rotating night shift work. PER1 gene expression was associated with the lifetime duration of rotating night shift work among women currently working night shifts (P=0.04). PER1 and PER3 transcript levels in blood leukocytes were significantly down-regulated in the later versus early hours of the morning between 06.00–10.00 hours (β-coefficient -0.226, P=0.001 and β-coefficient -0.181, P

Published
2013
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4. Dysregulation of markers of oxidative stress and DNA damage among nail technicians despite low exposure to volatile organic compounds

Author

Wojciech Wasowicz, Jolanta Gromadzinska, Magdalena Beata Krol, Anna Smok-Pieniazek, Radoslaw Swiercz, Peter Gresner, Ewa Twardowska, and Maciej Stępnik

Subjects
Pathology, GPX1, volatile organic compound, Physiology, dna, medicine.disease_cause, Superoxide Dismutase-1, Glutathione Peroxidase GPX1, Medicine, chemistry.chemical_classification, biology, Glutathione peroxidase, Ceruloplasmin, Middle Aged, Thiobarbiturates, medicine.anatomical_structure, Nail (anatomy), Biomarker (medicine), biomarker, Female, dna damage, Public aspects of medicine, RA1-1270, Environmental Monitoring, Adult, dysregulation, medicine.medical_specialty, DNA damage, voc, Air Pollutants, Occupational, Beauty Culture, Superoxide dismutase, nail technician, Nail technician, marker of oxidative stress, Humans, Glutathione Peroxidase, Volatile Organic Compounds, Superoxide Dismutase, business.industry, Public Health, Environmental and Occupational Health, occupational exposure, Oxidative Stress, Nails, chemistry, exposure, biology.protein, business, Biomarkers, Oxidative stress
Abstract

Objective The study aimed to compare levels of selected biomarkers of oxidative stress and DNA damage and their correlation with occupational exposure to volatile organic compounds (VOC) among female nail technicians and a group of unexposed volunteers. Methods A panel of biomarkers of oxidative stress and DNA damage was assayed among 145 female nail technicians and 152 healthy female volunteers. Occupational exposure of nail technicians to VOC was assessed analyzing the VOC content in nail salon air samples. Results The level of occupational exposure of nail technicians to VOC was below the respective threshold limit values with combined airborne exposure to a mixture of VOC, reaching only 3.3% (range 0.2–33.3%) of the threshold limit. Despite that, nail technicians presented increased activity of glutathione peroxidase 1 (GPx1), plasma ceruloplasmin, and the GPx1/superoxide dismutase 1 ratio (P

Published
2015

5. Circadian gene expression in peripheral blood leukocytes of rotating night shift nurses

Author

Jenny-Anne Lie, Edyta Wieczorek, Helge Kjuus, Beata Peplonska, Jolanta Gromadzinska, Wojciech Wasowicz, Edyta Reszka, Agnieszka Bukowska, and Wojciech Sobala

Subjects
Adult, medicine.medical_specialty, night shift, Circadian clock, nurse, Gene Expression, Nurses, night work, Shift work, Circadian Clocks, Work Schedule Tolerance, Internal medicine, Leukocytes, medicine, leukocycte, Humans, cancer, Circadian rhythm, sleep, gene, Morning, Circadian Rhythm Signaling Peptides and Proteins, business.industry, Public Health, Environmental and Occupational Health, Chronotype, Middle Aged, Circadian Rhythm, PER2, PER3, Cross-Sectional Studies, Endocrinology, shift work, chronotype, Female, circadian gene expression, shift worker, Public aspects of medicine, RA1-1270, business, PER1
Abstract

Objective It has been hypothesized that the underlying mechanism of elevated breast cancer risk among long-term, night-working women involves circadian genes expression alteration caused by exposure to light at night and/or irregular work hours. The aim of the present study was to determine the effect of rotating night shift work on expression of selected core circadian genes. Methods The cross-sectional study was conducted on 184 matched nurses and midwives, who currently work either day or rotating night shifts, to determine the effect of irregular work at night on circadian gene expression in peripheral blood leukocytes. Transcript levels of BMAL1, CLOCK, CRY1, CRY2, PER1, PER2, and PER3 were determined by means of quantitative real-time polymerase chain reaction (PCR). Results After adjusting for hour of blood collection, there were no statistically significant changes of investigated circadian genes among nurses and midwives currently working rotating night shifts compared to nurses working day shifts. The highest expression of PER1 messanger ribonucleic acid (mRNA) was observed for women currently working shifts who had worked >15 years in rotating night shift work. PER1 gene expression was associated with the lifetime duration of rotating night shift work among women currently working night shifts (P=0.04). PER1 and PER3 transcript levels in blood leukocytes were significantly down-regulated in the later versus early hours of the morning between 06.00–10.00 hours (β-coefficient -0.226, P=0.001 and β-coefficient -0.181, P

Published
2013

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