1. Triple network hypothesis-related disrupted connections in schizophrenia: A spectral dynamic causal modeling analysis with functional magnetic resonance imaging.
- Author
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Xi, Yi-Bin, Guo, Fan, Liu, Wen-Ming, Fu, Yu-Fei, Li, Jia-Ming, Wang, Hua-Ning, Chen, Fu-Lin, Cui, Long-Biao, Zhu, Yuan-Qiang, Li, Chen, Kang, Xiao-Wei, Li, Bao-Juan, and Yin, Hong
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FUNCTIONAL magnetic resonance imaging , *CAUSAL models , *DYNAMIC models , *SCHIZOPHRENIA , *DRUG target , *BRAIN , *RESEARCH , *NEURAL pathways , *NERVOUS system , *RESEARCH methodology , *BRAIN mapping , *MAGNETIC resonance imaging , *MEDICAL cooperation , *EVALUATION research , *COMPARATIVE studies - Abstract
Objective: The symptom-related neurobiology characteristic of schizophrenia in the brain from a network perspective is still poorly understood, leading to a lack of potential biologically-based markers and difficulty identifying therapeutic targets. We aim to test the dysregulated cross-network interactions among the Salience Network (SN), Central Executive Network (CEN) and Default Mode Network (DMN) and how they contributed to different symptoms in schizophrenia patients.Methods: We examined network interactions among the SN, CEN and DMN in 76 patients with schizophrenia vs. 80 well-matched controls using dynamic causal modeling (DCM). We further analyzed the relation between network dynamics and Positive and Negative Syndrome Scale (PANSS).Results: We observed that the DMN, CEN and SN across healthy controls and schizophrenia patients showed several similarities within or between-network pattern in the resting state. Comparing schizophrenia to controls, SN-centered cross-network interactions were most significantly reduced. Crucially, the strength of connections from CEN subnetwork 1 to DMN subnetwork 1 was positively correlated with the Positive Score of PANSS. The connection from the DMN subnetwork 2 to CEN subnetwork 2 was negatively correlated with the Negative Score of PANSS.Conclusions: Our study provides strong evidence for the dysregulation among SN, CEN and DMN in a triple-network perspective in schizophrenia. The connection between DMN and CEN could be clinically-relevant neurobiological signature of schizophrenia symptoms. Our study indicated that the description of brain triple network hypothesis could be a novel and possible bio-marker for schizophrenia. [ABSTRACT FROM AUTHOR]- Published
- 2021
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