1. An essential cell cycle regulation gene causes hybrid inviability in Drosophila.
- Author
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Phadnis, Nitin, Baker, Emily Clare P., Cooper, Jacob C., Frizzell, Kimberly A., Hsieh, Emily, de la Cruz, Aida Flor A., Shendure, Jay, Kitzman, Jacob O., and Malik, Harmit S.
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CELL cycle regulation , *HUMAN cell cycle , *MALE infertility , *HUMAN reproduction ,REPRODUCTIVE isolation - Abstract
Speciation, the process by which new biological species arise, involves the evolution of reproductive barriers, such as hybrid sterility or inviability between populations. However, identifying hybrid incompatibility genes remains a key obstacle in understanding the molecular basis of reproductive isolation.We devised a genomic screen, which identified a cell cycle-regulation gene as the cause of male inviability in hybrids resulting from a cross between Drosophila melanogaster and D. simulans. Ablation of the D. simulans allele of Drosophila melanogaster D. simulans D. simulans this gene is sufficient to rescue the adult viability of hybrid males. This dominantly acting cell cycle regulator causes mitotic arrest and, thereby, inviability of male hybrid larvae. Our genomic method provides a facile means to accelerate the identification of hybrid incompatibility genes in other model and nonmodel systems. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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