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Your search keyword '"Bendelac, Albert"' showing total 14 results
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14 results on '"Bendelac, Albert"'

2. Lysosomal Glycosphingolipid Recognition by NKT Cells

Author

Zhou, Dapeng, Mattner, Jochen, Cantu, Carlos, Schrantz, Nicolas, Yin, Ning, Gao, Ying, Sagiv, Yuval, Hudspeth, Kelly, Wu, Yun-Ping, Yamashita, Tadashi, Teneberg, Susann, Wang, Dacheng, Proia, Richard L., Levery, Steven B., Savage, Paul B., Teyton, Luc, and Bendelac, Albert

Published
2004

14. Editing of CD1d-Bound Lipid Antigens by Endosomal LipidTransfer Proteins.

Author

Sagiv, Yuval, Schrantz, Nicolas, Kulkarni, Ashok B., Qi, Xiaoyang, Mahuran, Don J., Morales, Carlos R., Grabowski, Gregory A., Benlagha, Kamel, Savage, Paul, Bendelac, Albert, Teyton, Luc, Zhou, Dapeng, and Cantu III, Carlos

Subjects
*LIPIDS, *T cells, *ANTIGENS, *LIPID metabolism, *IMMUNITY, *PROTEINS
Abstract

It is now established that CD1 molecules present lipid antigens to T cells, although it is not clear how the exchange of lipids between membrane compartments and the CD1 binding groove is assisted. We report that mice deficient in prosaposin, the precursor to a family of endosomal lipid transfer proteins (LTP), exhibit specific defects in CD 1d-mediated antigen presentation and lack Vα14 NKT cells. In vitro, saposins extracted monomeric lipids from membranes and from CD1, thereby promoting the loading as well as the editing of lipids on CD1. Transient complexes between CD1, lipid, and LTP suggested a "tug-of-war" model in which lipid exchange between CD1 and LTP is on the basis of their respective affinities for lipids. LTPs constitute a previously unknown link between lipid metabolism and immunity and are likely to exert a profound influence on the repertoire of self, tumor, and microbial lipid antigens. [ABSTRACT FROM AUTHOR]

Published
2004

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