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The article reports on a study which examined the Plasmodium parasites that causes malaria in which it consider as the most successful and deadly pathogens of vertebrates. The author of the study notes that using a Plasmodium berghei, a mouse model of malaria, they showed that the liver-stage parasite was kept its host hepatocyte alive long enough inorder to complete its development.They note that the Plasmodium parasites were transmitted to a host organism by the bite of a female Anopheles mosquito in which the sporozoite will form rapidly and invades the hepatocytes liver. The authors point out that using a cultured hepatocytes and histological analysis of infected mouse livers, they showed that the late liver-stage parasites have dissolved their surroundings in a vacuolar compartment.