1. RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance
- Author
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Douglas B. Fox, David T. Ting, Matthew R. Smith, Brian W. Brannigan, Ravi Kapur, Katherine T. Broderick, Sridhar Ramaswamy, Toshi Shioda, Kshitij S. Arora, Shyamala Maheswaran, Richard T. Lee, Chin-Lee Wu, David T. Miyamoto, Ben S. Wittner, Rushil Desai, Yu Zheng, Niyati Desai, Daniel A. Haber, Huili Zhu, Mehmet Toner, Julie Trautwein, Douglas M. Dahl, and Lecia V. Sequist
- Subjects
Male ,medicine.drug_class ,RNA Splicing ,Gene mutation ,Biology ,Wnt-5a Protein ,Mice ,Prostate cancer ,Circulating tumor cell ,Prostate ,Cell Line, Tumor ,Proto-Oncogene Proteins ,Nitriles ,Phenylthiohydantoin ,medicine ,Animals ,Humans ,Multidisciplinary ,Sequence Analysis, RNA ,Wnt signaling pathway ,Prostatic Neoplasms ,Androgen Antagonists ,Neoplastic Cells, Circulating ,Androgen ,medicine.disease ,Xenograft Model Antitumor Assays ,Wnt Proteins ,Androgen receptor ,medicine.anatomical_structure ,Drug Resistance, Neoplasm ,Receptors, Androgen ,Benzamides ,Immunology ,Cancer research ,Ectopic expression ,Single-Cell Analysis ,Transcriptome ,Signal Transduction - Abstract
Circulating signals of drug resistance Cancer drugs often lose their effectiveness because tumors acquire genetic changes that confer drug resistance. Ideally, patients would be switched to a different drug before tumor growth resumes, but this requires early knowledge of how resistance arose. Miyamoto et al. have developed a non-invasive method to spot resistance by sequencing RNA transcripts in single circulating tumor cells (CTCs) (see the Perspective by Nanus and Giannakakou). For example, in prostate cancer patients, drug resistance was triggered by activation of the Wnt signaling pathway. But CTCs are rare and fragile, and the technology needs further development before it is used in clinical practice. Science , this issue p. 1351 ; see also p. 1283
- Published
- 2015