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12 results on '"Just P"'

1. Fisheries rely on threatened salt marshes

Author

Baker, Ronald, Taylor, Matthew D, Able, Kenneth W, Beck, Michael W, Cebrian, Just, Colombano, Denise D, Connolly, Rod M, Currin, Carolyn, Deegan, Linda A, Feller, Ilka C, Gilby, Ben L, Kimball, Matthew E, Minello, Thomas J, Rozas, Lawrence P, Simenstad, Charles, Turner, R Eugene, Waltham, Nathan J, Weinstein, Michael P, Ziegler, Shelby L, Zu Ermgassen, Philine SE, Alcott, Caitlin, Alford, Scott B, Barbeau, Myriam A, Crosby, Sarah C, Dodds, Kate, Frank, Alyssa, Goeke, Janelle, Goodridge Gaines, Lucy A, Hardcastle, Felicity E, Henderson, Christopher J, James, W Ryan, Kenworthy, Matthew D, Lesser, Justin, Mallick, Debbrota, Martin, Charles W, McDonald, Ashley E, McLuckie, Catherine, Morrison, Blair H, Nelson, James A, Norris, Gregory S, Ollerhead, Jeff, Pahl, James W, Ramsden, Sarah, Rehage, Jennifer S, Reinhardt, James F, Rezek, Ryan J, Risse, L Mark, Smith, Joseph AM, Sparks, Eric L, and Staver, Lorie W

Subjects
Environmental Restoration and Remediation, Fisheries, United States, Wetlands, General Science & Technology
Published
2020

2. Highly Conserved Protective Epitopes on Influenza B Viruses

Author

Dreyfus, Cyrille, Laursen, Nick S., Kwaks, Ted, Zujdgeest, David, Khayat, Reza, Ekiert, Damian C., Lee, Jeong Hyun, Metlagel, Zoltan, Bujny, Miriam V., Jongeneelen, Mandy, der Vlugt, Remko van, Lamrani, Mohammed, Korse, Hans J. W. M., Geelen, Eric, Sahin, Özcan, Sieuwerts, Martijn, Brakenhoff, Just P. J., Vogels, Ronald, Li, Olive T. W., Poon, Leo L. M., Peiris, Malik, Koudstaal, Wouter, Ward, Andrew B., Wilson, Ian A., Goudsmit, Jaap, and Friesen, Robert H. E.

Published
2012

12. A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses.

Author

Ekiert, Damian C., Friesen, Robert H. E., Bhabha, Gira, Kwaks, Ted, Jongeneeten, Mandy, Yu, Wenli, Ophorst, Carla, Cox, Freek, Korse, Hans J.W.M., Brandenburg, Boerries, Vogels, Ronald, Brakenhoff, Just P. J., Kompier, Ronald, Koldijk, Martin H., Cornelissen, Lisette A. H. M., Poon, Leo L. M., Peiris, Malik, Koudstaal, Wouter, Wilson, Ian A., and Goudsmit, Jaap

Subjects
*VIRAL genetics, *INFLUENZA A virus, *IMMUNOGLOBULINS, *MONOCLONAL antibodies, *HEMAGGLUTININ, *EPITOPES, *INFLUENZA vaccines
Abstract

Current flu vaccines provide only limited coverage against seasonal strains of influenza viruses. The identification of VH1-69 antibodies that broadly neutralize almost all influenza A group 1 viruses constituted a breakthrough in the influenza field. Here, we report the isolation and characterization of a human monoclonal antibody CR8020 with broad neutralizing activity against most group 2 viruses, including H3N2 and H7N7, which cause severe human infection. The crystal structure of Fab CR8020 with the 3.968 pandemic H3 hemagglutinin (HA) reveals a highly conserved epitope in the HA stalk distinct from the epitope recognized by the VH1-69 group 1 antibodies. Thus, a cocktail of two antibodies may be sufficient to neutralize most influenza A subtypes and, hence, enable development of a universal flu vaccine and broad-spectrum antibody therapies. [ABSTRACT FROM AUTHOR]

Published
2011
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