1. Major subpopulations of Plasmodium falciparum in sub-Saharan Africa
- Author
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Archibald Worwui, Ben Andagalu, William Yavo, Roberto Amato, Lucas Amenga-Etego, Deus S. Ishengoma, Alfred Amambua-Ngwa, David Jeffries, Oumou Maïga-Ascofaré, Tobias O. Apinjoh, Oyebola Kolapo, Anita Ghansah, Edwin Kamau, Dominic P. Kwiatkowski, Milijaona Randrianarivelojosia, Umberto D'Alessandro, Karim Mane, Vikki Simpson, Lemu Golassa, Marielle K. Bouyou-Akotet, and Abdoulaye A. Djimde more...
- Subjects
0303 health sciences ,education.field_of_study ,Multidisciplinary ,030306 microbiology ,Human migration ,business.industry ,Haplotype ,Population ,Plasmodium falciparum ,Drug resistance ,Biology ,biology.organism_classification ,medicine.disease ,Genome ,3. Good health ,03 medical and health sciences ,Evolutionary biology ,parasitic diseases ,medicine ,Artemisinin ,education ,business ,Malaria ,030304 developmental biology ,medicine.drug - Abstract
Ebb and flow of parasite populations The population genetics of the malaria parasite Plasmodium falciparum across Africa is poorly understood but important to know for grasping the risks and dynamics of the spread of drug resistance. Harnessing the power of genomics, Amambua-Ngwa et al. of the Plasmodium Diversity Network Africa found substantial population structure within Africa that is consistent with human and vector population divergence (see the Perspective by Sibley). Specific signatures of selection by antimalarial drugs were detected, along with indications of the effect of colonization and slavery. Furthermore, whole-genome sequencing showed that there is extensive gene flow among the different regions and that Ethiopia has a distinctive population of P. falciparum , which may be indicative of coexistence with another malaria parasite, P. vivax. Science , this issue p. 813 ; see also p. 752 more...
- Published
- 2019