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1. Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis.

Author

Zhang, Min, Wang, Chengqi, Otto, Thomas D., Oberstaller, Jenna, Liao, Xiangyun, Adapa, Swamy R., Udenze, Kenneth, Bronner, Iraad F., Casandra, Deborah, Mayho, Matthew, Brown, Jacqueline, Li, Suzanne, Swanson, Justin, Rayner, Julian C., Jiang, Rays H. Y., and Adams, John H.

Subjects
*PLASMODIUM falciparum genetics, *TRANSPOSONS, *MUTAGENICITY testing, *GENES, *MALARIA
Abstract

The article presents a research summary of an article found online at http://dx.doi.org/10.1125/science.aap7847 on the genetics of the malaria-causing parasite Plasmodium falciparum. It states that high-throughput piggyBac transposon insertional mutagenesis and quantitative insertion site sequencing was used to achieve saturation mutagenesis (SM) of Plasmodium falciparum. It reports SM allowed intervention target prioritization to identify over 1,000 Plasmodium-conserved essential genes.

Published
2018
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