Search

Your search keyword '"Vijayraghavan S"' showing total 2 results
Start Over Author "Vijayraghavan S" Journal science
2 results on '"Vijayraghavan S"'

2. Protein Kinase C Overactivity Impairs Prefrontal CorticalRegulation of Working Memory.

Author

Birnbaum, S. C., Yuan, P. X., Wang, M., Vijayraghavan, S., Bloom, A. K., Davis, D. J., Gobeske, K. T., Sweatt, J. D., Manji, H. K., and Arnsten, A. F. T.

Subjects
*PREFRONTAL cortex, *FRONTAL lobe, *PROTEIN kinases, *SHORT-term memory, *PSYCHOLOGICAL stress, *CEREBRAL cortex
Abstract

The prefrontal cortex is a higher brain region that regulates thought, behavior, and emotion using representational knowledge, operations often referred to as working memory. We tested the influence of protein kinase C (PKC) intracellular signaling on prefrontal cortical cognitive function and showed that high levels of PKC activity in prefrontal cortex, as seen for example during stress exposure, markedly impair behavioral and electrophysiological measures of working memory. These data suggest that excessive PKC activation can disrupt prefrontal cortical regulation of behavior and thought, possibly contributing to signs of prefrontal cortical dysfunction such as distractibility, impaired judgment, impulsivity, and thought disorder. [ABSTRACT FROM AUTHOR]

Published
2004
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results