1. Dendritic Cell—Induced Memory T Cell Activation in Nonlymphoid Tissues.
- Author
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Wakim, Linda M., Waithman, Jason, Van Rooijen, Nico, Heath, William R., and Carbone, Francis R.
- Subjects
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T cells , *DENDRITIC cells , *LYMPHOID tissue , *NONLYMPHOID leukemia , *HERPES simplex virus , *CYTOLOGY , *EPITHELIAL cells , *DENDRITES , *ANTIGENS - Abstract
Secondary Lymphoid organs are dominant sites of T cell activation, although many T cells are subsequently retained within peripheral tissues. Currently, these nonlymphoid compartments are viewed as sites only of effector T cell function, without the involvement of renewed induction of immunity via the interactions with professional antigen-presenting cells. We describe a method of reactivation of herpes simplex virus to examine the stimulation of tissue-resident T cells during secondary challenge. The results revealed that memory CD8+ T cell responses can be initiated within peripheral tissues through a tripartite interaction that includes CD4+ T cells and recruited dendritic cells. These findings lend evidence for the existence of a sophisticated T cell response mechanism in extra-lymphoid tissues that can act to control localized infection. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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