1. Migratory DCs activate TGF-β to precondition naïve CD8
- Author
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Vinidhra Mani, Thorsten R. Mempel, Adam Lacy-Hulbert, Kate L. Jeffrey, Mark A. Travis, Alexandra Y. Chasse, Shannon K. Bromley, Francesco Marangoni, Tarmo Äijö, Ross D. Warner, Craig P. McEntee, Jason W. Griffith, Debattama R. Sen, Moustafa Hamze, Alina Lorant, Rut Mora-Buch, Esteban Carrizosa, Rod A. Rahimi, and Andrew D. Luster
- Subjects
0301 basic medicine ,Naive T cell ,General Science & Technology ,medicine.medical_treatment ,T-Lymphocytes ,1.1 Normal biological development and functioning ,Spleen ,Mice, Transgenic ,Biology ,CD8-Positive T-Lymphocytes ,Major histocompatibility complex ,Inbred C57BL ,Article ,Transgenic ,Vaccine Related ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Underpinning research ,Cell Movement ,Transforming Growth Factor beta ,medicine ,Cytotoxic T cell ,Animals ,Skin ,Autoimmune disease ,Multidisciplinary ,Prevention ,Inflammatory and immune system ,Dendritic Cells ,Integrin alphaV ,medicine.disease ,Cell biology ,Mice, Inbred C57BL ,030104 developmental biology ,medicine.anatomical_structure ,Cytokine ,030220 oncology & carcinogenesis ,biology.protein ,Immunization ,Lymph Nodes ,Epidermis ,Immunologic Memory ,CD8 ,Transforming growth factor - Abstract
Some naïve T cell fates are sealed Tissue-resident memory T (T RM ) cells constitute a subpopulation of memory cells that reside in tissues instead of recirculating. CD8 + epithelial TRM (eT RM ) cells, which occupy the epithelium of sites like the skin, require transforming growth factor–β (TGF-β) for their development. Mani et al. found that α V integrin–expressing dendritic cells, which activate and present TGF-β, are key (see the Perspective by Farber). Surprisingly, this interplay did not occur in the skin or draining lymph nodes during T cell priming. Rather, resting naïve CD8 + T cells interacted with α V integrin–expressing migratory dendritic cells during immune homeostasis, reversibly preconditioning them to become eT RM cells upon activation. A potent cytokine is thus controlled in a context-dependent manner and preimmune T cell repertoires may be less uniform than previously presumed. Science , this issue p. eaav5728 ; see also p. 188
- Published
- 2018