1. Anemic stress as a trigger of myelogenous leukemia in rats rendered leukemia-prone by x-ray
- Author
-
Joseph K. Gong
- Subjects
medicine.medical_specialty ,Time Factors ,Anemia ,Blood volume ,Bone Marrow Cells ,Radiation Dosage ,Leukemogenic ,Myelogenous ,Leukocyte Count ,Internal medicine ,medicine ,Animals ,Bloodletting ,Leukemia, Radiation-Induced ,Multidisciplinary ,Auer rod ,business.industry ,medicine.disease ,Basophils ,Blood Cell Count ,Rats ,Leukemia ,Leukemia, Myeloid, Acute ,Radiation Injuries, Experimental ,Endocrinology ,Immunology ,Female ,business - Abstract
All of the 128 Sprague-Dawley female rats bled two-thirds of the blood volume at 1, 2, or 3 months after irradiation (50, 170, or 350 roentgens) succumbed to leukemia by 16 months after bleeding. Some nonbled irradiated rats developed leukemia possibly as a result of triggering by a radiation-induced anemia. The threshold leukemogenic x-ray dose is probably below 25 roentgens. Elevated levels of basophils, neutrophils containing the "pseudo-Pelger" type nuclear anomaly, and myeloblasts exhibiting Auer rods seen in these animals were generally not found in earlier models of rat myelogenous leukemia.
- Published
- 1971