Author: "Faull, Sarah V." / Journal: science advances - Searchworks@Jio Institute Digital Library Search Results

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Start Over Author "Faull, Sarah V." Journal science advances

Author: Faull, Sarah V., primary, Elliston, Emma L. K., additional, Gooptu, Bibek, additional, Jagger, Alistair M., additional, Aldobiyan, Ibrahim, additional, Redzej, Adam, additional, Badaoui, Magd, additional, Heyer-Chauhan, Nina, additional, Rashid, S. Tamir, additional, Reynolds, Gary M., additional, Adams, David H., additional, Miranda, Elena, additional, Orlova, Elena V., additional, Irving, James A., additional, and Lomas, David A., additional
Published: 2020
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Author: Faull, Sarah V., Elliston, Emma L. K., Gooptu, Bibek, Jagger, Alistair M., Aldobiyan, Ibrahim, Redzej, Adam, Badaoui, Magd, Heyer-Chauhan, Nina, Rashid, S. Tamir, Reynolds, Gary M., Adams, David H., Miranda, Elena, Orlova, Elena V., Irving, James A., and Lomas, David A.
Subjects: *TRYPSIN, *UNFOLDED protein response, *NUCLEAR magnetic resonance spectroscopy, *ION mobility spectroscopy, *POLYMERIZATION
Abstract: The article discusses the serpinopathies have a diverse set of conformational diseases that involve the aberrant self-association of proteins to ordered aggregates. Topics include genetic variants such as the severe Z allele of 1-antitrypsin promote proteasomal degradation and the formation of ordered linear polymers; and the structure of the pathological polymers accumulate in patients has not been demonstrated.
Published: 2020
Full Text: View/download PDF

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