1. A microneedle platform for buccal macromolecule delivery
- Author
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Joy Collins, Andreas Vegge, Frantisek Hubalek, Shane McDonnell, Tadayuki Yoshitake, Fauziah R. Zakaria, Jacob Wainer, Ryan Yu Tian, Ulrik Lytt Rahbek, Soyoung Kim, Robert Langer, Giovanni Traverso, Alison Hayward, Raissa Yona, Xiaoya Lu, Ester Caffarel-Salvador, Vance Soares, Morten Revsgaard Frederiksen, Daniel Minahan, Keiko Ishida, Jessica Wong, Rebecca McManus, Xiewen Liu, Siddartha Tamang, James G. Fujimoto, Johannes Josef Fels, Sarah R. Stern, and Niclas Roxhed
- Subjects
Drug ,Multidisciplinary ,business.industry ,media_common.quotation_subject ,Medication adherence ,02 engineering and technology ,Buccal administration ,021001 nanoscience & nanotechnology ,Oral cavity ,030226 pharmacology & pharmacy ,03 medical and health sciences ,0302 clinical medicine ,Application site ,Healthy volunteers ,Drug delivery ,Medicine ,0210 nano-technology ,business ,media_common ,Biomedical engineering ,Transdermal - Abstract
Alternative means for drug delivery are needed to facilitate drug adherence and administration. Microneedles (MNs) have been previously investigated transdermally for drug delivery. To date, drug loading into MNs has been limited by drug solubility in the polymeric blend. We designed a highly drug-loaded MN patch to deliver macromolecules and applied it to the buccal area, which allows for faster delivery than the skin. We successfully delivered 1-mg payloads of human insulin and human growth hormone to the buccal cavity of swine within 30 s. In addition, we conducted a trial in 100 healthy volunteers to assess potential discomfort associated with MNs when applied in the oral cavity, identifying the hard palate as the preferred application site. We envisage that MN patches applied on buccal surfaces could increase medication adherence and facilitate the painless delivery of biologics and other drugs to many, especially for the pediatric and elderly populations.
- Published
- 2020