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Runoffs in the Yellow River and Yangtze River basins, China, have been changing constantly during the last half century. In this paper, data from eight river gauging stations and 529 meteorological stations, inside and adjacent to the study basins, were analyzed and compared to quantify the hydrological processes involved, and to evaluate the role of human activities in changing river discharges. The Inverse Distance Weighted (IDW) interpolation method was used to obtain climatic data coverage from station observations. According to the runoff coefficient equation, the effect of human activities and climate can be expressed by changes in runoff coefficients and changes in precipitation, respectively. Annual runoff coefficients were calculated for the period 1950-2008, according to the correlation between respective hydrological series and regional precipitation. Annual precipitation showed no obvious trend in the upper reaches of the Yellow River but a marked downward trend in the middle and downstream reaches, with declines of 8.8 and 9.8 mm/10 a, respectively. All annual runoff series for the Yellow River basin showed a significant downward trend. Runoff declined by about 7.8 mm/10 a at Sanmenxia and 10.8 mm/10 a at Lijin. The series results indicated that an abrupt change occurred in the late 1980s to early 1990s. The trend of correlations between annual runoff and precipitation decreased significantly at the Yellow River stations, with rates ranging from 0.013/10 a to 0.019/10 a. For the hydrologic series, all precipitation series showed a downward trend in the Yangtze River basin with declines ranging from about 24.7 mm/10 a at Cuntan to 18.2 mm/10 a at Datong. Annual runoff series for the upper reaches of the Yangtze River decreased significantly, at rates ranging from 9.9 to 7.2 mm/10 a. In the middle and lower reaches, the runoff series showed no significant trend, with rates of change ranging from 2.1 to 2.9 mm/10 a. Human activities had the greatest influence on changes in the hydrological series of runoff, regardless of whether the effect was negative or positive. During 1970-2008, human activities contributed to 83% of the reduction in runoff in the Yellow River basin, and to 71% of the increase in runoff in the Yangtze River basin. Moreover, the impacts of human activities across the entire basin increased over time. In the 2000s, the impact of human activities exceeded that of climate change and was responsible for 84% of the decrease and 73% of the increase in runoff in the Yellow River and Yangtze River basins, respectively. The average annual runoff from 1980 to 2008 fell by about 97%, 83%, 83%, and 91%, compared with 1951-1969, at the Yellow River stations Lanzhou, Sanmenxia, Huayuankou and Lijin, respectively. Most of the reduction in runoff was caused by human activities. Changes in precipitation also caused reductions in runoff of about 3%, 17%, 17%, and 9% at these four stations, respectively. Falling precipitation rates were the main explanation for runoff changes at the Yangtze River stations Cuntan, Yichang, Hankou, and Datong, causing reductions in runoff of 89%, 74%, 43%, and 35%, respectively. Underlying surface changes caused decreases in runoff in the Yellow River basin and increases in runoff in the Yangtze River basin. Runoff decreased in arid areas as a result of increased water usage, but increased in humid and sub-humid areas as a result of land reclamation and mass urbanization leading to decreases in evaporation and infiltration. [ABSTRACT FROM AUTHOR]