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Start Over Author "de Vries, Rory D" Journal science immunology
6 results on '"de Vries, Rory D"'

1. Antigenic cartography of SARS-CoV-2 reveals that Omicron BA.1 and BA.2 are antigenically distinct

Author

Mykytyn, Anna Z., primary, Rissmann, Melanie, additional, Kok, Adinda, additional, Rosu, Miruna E., additional, Schipper, Debby, additional, Breugem, Tim I., additional, van den Doel, Petra B., additional, Chandler, Felicity, additional, Bestebroer, Theo, additional, de Wit, Maurice, additional, van Royen, Martin E., additional, Molenkamp, Richard, additional, Oude Munnink, Bas B., additional, de Vries, Rory D., additional, GeurtsvanKessel, Corine, additional, Smith, Derek J., additional, Koopmans, Marion P. G., additional, Rockx, Barry, additional, Lamers, Mart M., additional, Fouchier, Ron A. M., additional, and Haagmans, Bart L., additional

Published
2022
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2. Divergent SARS-CoV-2 Omicron–reactive T and B cell responses in COVID-19 vaccine recipients

Author

GeurtsvanKessel, Corine H., primary, Geers, Daryl, additional, Schmitz, Katharina S., additional, Mykytyn, Anna Z., additional, Lamers, Mart M., additional, Bogers, Susanne, additional, Scherbeijn, Sandra, additional, Gommers, Lennert, additional, Sablerolles, Roos S. G., additional, Nieuwkoop, Nella N., additional, Rijsbergen, Laurine C., additional, van Dijk, Laura L. A., additional, de Wilde, Janet, additional, Alblas, Kimberley, additional, Breugem, Tim I., additional, Rijnders, Bart J. A., additional, de Jager, Herbert, additional, Weiskopf, Daniela, additional, van der Kuy, P. Hugo M., additional, Sette, Alessandro, additional, Koopmans, Marion P. G., additional, Grifoni, Alba, additional, Haagmans, Bart L., additional, and de Vries, Rory D., additional

Published
2022
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3. SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients

Author

Geers, Daryl, primary, Shamier, Marc C., additional, Bogers, Susanne, additional, den Hartog, Gerco, additional, Gommers, Lennert, additional, Nieuwkoop, Nella N., additional, Schmitz, Katharina S., additional, Rijsbergen, Laurine C., additional, van Osch, Jolieke A. T., additional, Dijkhuizen, Emma, additional, Smits, Gaby, additional, Comvalius, Anouskha, additional, van Mourik, Djenolan, additional, Caniels, Tom G., additional, van Gils, Marit J., additional, Sanders, Rogier W., additional, Oude Munnink, Bas B., additional, Molenkamp, Richard, additional, de Jager, Herbert J., additional, Haagmans, Bart L., additional, de Swart, Rik L., additional, Koopmans, Marion P. G., additional, van Binnendijk, Robert S., additional, de Vries, Rory D., additional, and GeurtsvanKessel, Corine H., additional

Published
2021
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4. Phenotype and kinetics of SARS-CoV-2–specific T cells in COVID-19 patients with acute respiratory distress syndrome

Author

Weiskopf, Daniela, primary, Schmitz, Katharina S., additional, Raadsen, Matthijs P., additional, Grifoni, Alba, additional, Okba, Nisreen M. A., additional, Endeman, Henrik, additional, van den Akker, Johannes P. C., additional, Molenkamp, Richard, additional, Koopmans, Marion P. G., additional, van Gorp, Eric C. M., additional, Haagmans, Bart L., additional, de Swart, Rik L., additional, Sette, Alessandro, additional, and de Vries, Rory D., additional

Published
2020
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5. Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles

Author

Petrova, Velislava N., primary, Sawatsky, Bevan, additional, Han, Alvin X., additional, Laksono, Brigitta M., additional, Walz, Lisa, additional, Parker, Edyth, additional, Pieper, Kathrin, additional, Anderson, Carl A., additional, de Vries, Rory D., additional, Lanzavecchia, Antonio, additional, Kellam, Paul, additional, von Messling, Veronika, additional, de Swart, Rik L., additional, and Russell, Colin A., additional

Published
2019
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6. Antigenic cartography of SARS-CoV-2 reveals that Omicron BA.1 and BA.2 are antigenically distinct

Author

Anna Z. Mykytyn, Melanie Rissmann, Adinda Kok, Miruna E. Rosu, Debby Schipper, Tim I. Breugem, Petra B. van den Doel, Felicity Chandler, Theo Bestebroer, Maurice de Wit, Martin E. van Royen, Richard Molenkamp, Bas B. Oude Munnink, Rory D. de Vries, Corine GeurtsvanKessel, Derek J. Smith, Marion P. G. Koopmans, Barry Rockx, Mart M. Lamers, Ron A. M. Fouchier, Bart L. Haagmans, Mykytyn, Anna Z [0000-0001-7188-6871], Rissmann, Melanie [0000-0002-5298-5919], Kok, Adinda [0000-0003-3635-7952], Rosu, Miruna E [0000-0003-3469-7822], Schipper, Debby [0000-0001-6449-4765], Breugem, Tim I [0000-0002-5558-7043], van den Doel, Petra B [0000-0002-5735-5537], Chandler, Felicity [0000-0002-3465-6409], de Wit, Maurice [0000-0003-0449-8822], van Royen, Martin E [0000-0002-6814-0996], Molenkamp, Richard [0000-0002-9004-3850], Oude Munnink, Bas B [0000-0002-9394-1189], de Vries, Rory D [0000-0003-2817-0127], GeurtsvanKessel, Corine [0000-0002-7678-314X], Smith, Derek J [0000-0002-2393-1890], Koopmans, Marion PG [0000-0002-5204-2312], Rockx, Barry [0000-0003-2463-027X], Lamers, Mart M [0000-0002-1431-4022], Fouchier, Ron AM [0000-0001-8095-2869], Haagmans, Bart L [0000-0001-6221-2015], Apollo - University of Cambridge Repository, Virology, Neurology, and Pathology

Subjects
SDG 3 - Good Health and Well-being, SARS-CoV-2, Cricetinae, Immune Sera, Immunology, Animals, COVID-19, Humans, General Medicine, Cell Line
Abstract

The emergence and rapid spread of SARS-CoV-2 variants may affect vaccine efficacy substantially. The Omicron variant termed BA.2, which differs substantially from BA.1 based on genetic sequence, is currently replacing BA.1 in several countries, but its antigenic characteristics have not yet been assessed. Here, we used antigenic cartography to quantify and visualize antigenic differences between early SARS-CoV-2 variants (614G, Alpha, Beta, Gamma, Zeta, Delta, and Mu) using hamster antisera obtained after primary infection. We first verified that the choice of the cell line for the neutralization assay did not affect the topology of the map substantially. Antigenic maps generated using pseudo-typed SARS-CoV-2 on the widely used VeroE6 cell line and the human airway cell line Calu-3 generated similar maps. Maps made using authentic SARS-CoV-2 on Calu-3 cells also closely resembled those generated with pseudo-typed viruses. The antigenic maps revealed a central cluster of SARS-CoV-2 variants, which grouped on the basis of mutual spike mutations. Whereas these early variants are antigenically similar, clustering relatively close to each other in antigenic space, Omicron BA.1 and BA.2 have evolved as two distinct antigenic outliers. Our data show that BA.1 and BA.2 both escape vaccine-induced antibody responses as a result of different antigenic characteristics. Thus, antigenic cartography could be used to assess antigenic properties of future SARS-CoV-2 variants of concern that emerge and to decide on the composition of novel spike-based (booster) vaccines.

Published
2022

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