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Investigators in the United States and Spain have published new antibiotics data. Study 1: Moxifloxacin was as effective as piperacillin-tazobactam and amoxicillin-clavulanate for the treatment of complicated intra-abdominal infections. Scientists [...]

A program designed by the government of Quebec and several medical societies to educate physicians regarding the diagnosis and appropriate treatment for acute bacterial rhinosinusitis has led to a marked [...]

Quinolones sensitize Gram-negative bacteria to antimicrobial peptides. 'The treatment of infections caused by bacteria resistant to the vast majority of antibiotics is a challenge worldwide. Antimicrobial peptides (APs) make up [...]

The mechanisms of antimicrobial resistance in bacteria are reviewed in a recent issue of the American Journal of Medicine. According to the review, 'The treatment of bacterial infections is increasingly [...]

Community-wide isoniazid prophylaxis may speed the emergence of drug-resistant tuberculosis. According to recent research from the United States, 'In sub-Saharan Africa, where the emergence of HIV has caused dramatic increases [...]

Antibiotics are overused for adult upper respiratory infections in outpatient settings in the United States. 'Studies have suggested that antibiotics are often inappropriately used in the treatment of acute upper [...]

The prevalence of Mycobacterium tuberculosis drug resistance from 1993-2002 in Greece has been documented. In a recently published study, investigators in Greece conducted a study to 'document the prevalence of [...]

Genotype-guided HAART in early HIV-1 infection may be effective against drug-resistant virus. According to a recently published report in the Journal of Acquired Immune Deficiency Syndromes, 'Transmitted resistance to antiretroviral [...]

Drug resistance data are the focus of recent research from France, Germany and the South Korea. Study 1: Gyrase mutations have been identified in quinolone-resistant and -hypersusceptible Mycobacterium tuberculosis isolates. [...]

Targeting multidrug resistance in cancer was discussed. According to recent research from the United States, & quot;Effective treatment of metastatic cancers usually requires the use of toxic chemotherapy. In most [...]

Staphylococcus aureus vulnerability to antibiotic treatment may be linked to location in osteomyelitis. 'S. aureus is responsible for 80% of human osteomyelitis. It can invade and persist within osteoblasts,' investigators [...]

Chemotherapy drug resistance for breast cancer may be modified with dofequidar fumarate. 'Recent developments with chemotherapy for breast cancer have improved patient survival. However, there continue to be nonresponders to [...]

Daptomycin is effective for the treatment of Gram-positive infections. 'Daptomycin is a cyclic lipopeptide approved for use by the U.S. Food and Drug Administration (FDA) for the treatment of complicated [...]

Chromosomal alterations were purported to be the cause of drug resistance in cancer cells. 'Conventional mutation-selection theories have failed to explain (i) how cancer cells become spontaneously resistant against cytotoxic [...]

Scientists have identified point mutations in Mycobacterium tuberculosis genes associated with drug resistance. According to recent research published in the Journal of Microbiological Methods, 'Global public health is threatened by [...]

Antibiotic resistance in Neisseria gonorrhoeae is rendering gonorrhea untreatable; better prevention, diagnosis, and treatment are critical. According to recent research published in the journal Clinical Infectious Diseases, 'The incidence of [...]

Linezolid is effective for the treatment of multidrug-resistant tuberculosis. 'In vitro studies have shown good activity of linezolid against Mycobacterium tuberculosis, including multidrug-resistant strains. However, clinical experience with linezolid in [...]

A researcher reviews the antimicrobial armamentarium in a recent issue of the journal Pharmacotherapy. According to the review from the United States, 'The development and introduction of new antibiotics has, [...]

Mycobacterium tuberculosis EmbB306 mutations may increase drug resistance as well as the transmission of drug-resistant isolates. According to recent research from the United States, 'Mutations at position 306 of embB [...]

Intravenous colistin is highly active against multiresistant Gram-negative bacteria, alone or in combination with other agents. 'Colistin, an antibiotic almost abandoned for intravenous administration for many years due to its [...]

Antibiotic exposure impedes pneumococcal meningitis vaccine protection. 'The frequency of meningitis due to penicillin-resistant Streptococcus pneumoniae (PRP) has increased in recent years, making treatment failure more likely. It is currently [...]

HIV infection may not be associated with drug resistant tuberculosis. According to recent research from India, 'Tuberculosis is the commonest opportunistic disease in persons infected with human immunodeficiency virus (HIV). [...]

Use of antibiotic therapy for acne vulgaris may be contributing to treatment resistance. 'Antibiotic therapy has been integral to the management of inflammatory acne vulgaris for many years. Systemic antibiotics [...]

The problem of increasing antibiotic resistance in cases of Streptococcus pneumoniae, a major cause of pneumonia, meningitis and sepsis, was dramatically reversed following the licensing and use of a new [...]

Researchers are developing drugs to inhibit drug-resistant HIV-1 reverse transcriptases. 'HIV undergoes rapid genetic variation; this variation is caused primarily by the enormous number of viruses produced daily in an [...]