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Local anaesthetics are among the most used drugs in clinical practice, but once they are released to the environment, the effects on the aquatic fauna remain uncertain. This study evaluates, for the first time, the impact of tetracaine, lidocaine and bupivacaine on the survival rate and physiological effects of cladocera Daphnia magna. Video-tracking and image processing allowed us to obtain changes in behaviour parameters like swimming average velocity and mean square displacement. We found that tetracaine shows the most severe effect. A high-speed microscopy system was also used to determine the response of D. magna heart to these drugs. Our results show that tetracaine presents dose-dependent area reduction during all cardiac cycle, while bupivacaine and lidocaine did not present significative effects on heart size. The tested drugs, at environmental high concentrations, altered behaviour, heart function and survival of D. magna. Unlabelled Image • Local anaesthetics affect the motility of D. magna. • Tetracaine produces total immobility to D. magna. • Local anaesthetics reduce the cardiac frequency of D. magna. • The release of local anaesthetics is an environmental risk. [ABSTRACT FROM AUTHOR]

Multiple sources contribute to the presence of antibiotic residues in water environments, and the environmental risks caused by antibiotics were paid more and more attention. This work aims to establish a relationship between optical properties of dissolved organic matter (DOM) and sources and risks of antibiotics. Occurrence of antibiotics and DOM in a city-river-reservoir freshwater system containing distinct antibiotic sources was investigated during three seasons using LC-MS and fluorescence excitation-emission matrix coupled with parallel factor analysis (EEM-PARAFAC), respectively. The results showed that antibiotics and DOM in the water had trends of increasing levels from the upstream to the midstream in the system. Five classes of antibiotics had statistically significant correlations with the humic-like component (C3) in the water (Pearson, p < 0.05). Especially, norfloxacin (NFX), which was dominant in the aquaculture source, significantly increased the fluorescence of C3 according to the fluorescence titration (R 2 = 0.86, p < 0.01). Furthermore, fluorescence signature in the aquaculture pond posed broad humic acid-like peaks with relatively higher abundances compared to other areas. These results suggested that C3 could be recognized as an indicator of NFX from aquaculture sources. Meanwhile, C3 can largely account for ecological risks of tetracyclines according to the results of redundancy analysis. This work highlights the roles of EEM-PARAFAC on tracing the source of antibiotics and the correlations between environmental risks of antibiotics and DOM in the aquatic environment. Unlabelled Image • Correlations between antibiotics and optical properties of DOM could be used to indicate antibiotics in freshwater system. • Sources and risks of antibiotics related to EEM-PARAFAC components were assessed by PMF and RQ method, respectively. • Spatiotemporal variations of antibiotics and DOM were investigated. • Fluorescence signature posed more remarkable peaks of humic-like materials in aquaculture area than those in other area. • Humic acid-like materials (Ex/Em=240(295)/430 nm) could indicate NFX from aquaculture source. [ABSTRACT FROM AUTHOR]

The interpretation of the mutagenic potential of silver nanoparticles as a mathematical function of (i) dose; (ii) coating; and (iii) type of mutagenicity (TA98 and TA100) gives quantitative models with good statistical quality. So-called quasi-SMILES are used to represent examined objects (silver nanoparticles under different conditions) for building up models. Simplified molecular input-line entry systems (SMILES) is a well-known sequence of symbols for representation of the molecular structure. Quasi-SMILES is a similar sequence of symbols for representation of experimental conditions. The Correlation Contradiction Index (CCI) calculated with data on the calibration set gives possibility to predict quality of correlation of "experimental vs. calculated values of endpoint" for external validation set. Unlabelled Image • The number of colonies per plate (N cp) examined as measure of the mutagenicity. • Quasi-SMILES technique is applied to build up model for N cp. • Index of Ideality of Correlation is tested as a criterion of predictive potential. • Correlation Contradiction Index tested as a criterion of predictive potential. [ABSTRACT FROM AUTHOR]

Abstract Microcystins (MCs) and cylindrospermopsin (CYN) are among the most frequent toxins produced by cyanobacteria. These toxic secondary metabolites are classified as hepatotoxins and cytotoxin, respectively. Furthermore, both may present the ability to induce damage to the nervous system. In this sense, there are many studies manifesting the potential of MCs to cause neurotoxicity both in vitro and in vivo , due to their probable capacity to cross the blood-brain-barrier through organic anion transporting polypeptides. Moreover, the presence of MCs has been detected in brain of several experimental models. Among the neurological effects, histopathological brain changes, deregulation of biochemical parameters in brain (production of oxidative stress and inhibition of protein phosphatases) and behavioral alterations have been described. It is noteworthy that minority variants such as MC-LF and -LW have demonstrated to exert higher neurotoxic effects compared to the most studied congener, MC-LR. By contrast, the available studies concerning CYN-neurotoxic effects are very scarce, mostly showing inflammation and apoptosis in neural murine cell lines, oxidative stress, and alteration of the acetylcholinesterase activity in vivo. However, more studies are required in order to clarify the neurotoxic potential of both toxins, as well as their possible contribution to neurodegenerative diseases. Graphical abstract Unlabelled Image Highlights • MCs produce pathological damage in brain and behavioral changes in several species. • MC–LF and -LW could be more neurotoxic than MC-LR. • Neurotoxic effects have been less studied in MC-RR than in MC-LR. • CYN produces apoptosis, oxidative stress and AChE alteration in neural cells. [ABSTRACT FROM AUTHOR]

Abstract Cadmium (Cd) and lead (Pb) that accumulates in the surface soil of railway rock-cut slopes may migrate to nearby croplands. It is important to determine whether backfill soil type influences the transportation of Cd and Pb in the surface soil. Representative rock-cut slopes, backfill soil of 100% rock fragments, 100% agricultural soil, and 50% agricultural soil and 50% rock fragments (n = 2 for each type) were selected. The pollution and migration levels of Cd and Pb and the soil quality and erodibility were investigated. The soil concentrations of Cd and Pb on the rock-cut slopes were much higher than those of China soil quality standard. Soil erosion was the most important factor that influences the migration of Cd and Pb in the slopes. Increasing the percentage of agricultural soil in the backfill soil resulted in decreasing the diffusion of Cd and Pb by reducing soil erosion. The backfill soil affected the soil quality and erosion durability, which, in turn, affected the transportation of Cd and Pb in the runoff. The soil quality index (SQI) accurately reflects the soil quality and can serve as an indicator of the migration of Cd and Pb on the surface soil of the slopes. Therefore, agricultural soil was more appropriate to use as a backfill soil in slope revegetation practice than was the rock fragment, which was helpful for decreasing the environmental risk of Cd and Pb on the slopes. Graphical abstract Unlabelled Image Highlights • A study on mitigating cadmium and lead pollution via backfill soil was conducted. • Pollutant concentration, soil quality, erosion durability, and rainfall impacts were considered. • Adding agricultural soil in backfill soil was best at containing both heavy metals. • The soil quality index (SQI) can serve as an indicator of Cd and Pb transformation. [ABSTRACT FROM AUTHOR]

Abstract Acetylcholinesterase (AChE) inhibitors, dihydrofolate reductase inhibitors (DHFR), Toxicity in Tetrahymena pyriformis (TP), Acute Toxicity in fathead minnow (TFat), Water solubility (WS), and Acute Aquatic Toxicity in Daphnia magna (DM) are examined as endpoints to establish quantitative structure – property/activity relationships (QSPRs/QSARs). The Index of Ideality of Correlation (IIC) is a measure of predictive potential. The IIC has been studied in a few recent works. The comparison of models for the six endpoints above confirms that the index can be a useful tool for building up and validation of QSPR/QSAR models. All examined endpoints are important from an ecologic point of view. The diversity of examined endpoints confirms that the IIC is real criterion of the predictive potential of a model. Graphical abstract Unlabelled Image Highlights • The index of Ideality of Correlation (IIC) is a criterion of predictive potential. • The IIC was used to build up models for endpoints related to human health. • The IIC was used to build up models for endpoints related to environmental risk. • The use of the IIC improves the statistical quality of the models. [ABSTRACT FROM AUTHOR]

Abstract The successful treatment of infectious diseases heavily relies on the therapeutic usage of antibiotics. However, the high use of antibiotics in humans and animals leads to increasing pressure on bacterial populations in favour of resistant phenotypes. Antibiotics reach the environment from a variety of emission sources and are being detected at relatively low concentrations. Given the possibility of selective pressure to occur at sub-inhibitory concentrations, the ecological impact of environmental antibiotic levels on microbial communities and resistance levels is vastly unknown. Quantification of antibiotic-resistance genes (ARG) and of antibiotic concentrations is becoming commonplace. Yet, these two parameters are often assessed separately and in a specific spatiotemporal context, thus missing the opportunity to investigate how antibiotics and ARGs relate. Furthermore, antibiotic (multi)resistance has been receiving ever growing attention from researchers, policy-makers, businesses and civil society. Our aim was to collect the limited data on antibiotic concentrations and ARG abundance currently available to explore if a relationship could be defined in surface waters, sediments and wastewaters. A metric of antibiotic selective pressure, i.e. the sum of concentrations corrected for microbial inhibition potency, was used to correlate the presence of antibiotics in the environment to total relative abundance of ARG while controlling for basic sources of non-independent variability, such as country, year, study, sample and antibiotic class. The results of this meta-analysis show a significant statistical effect of antibiotic pressure and type of environmental compartment on the increase of ARG abundance even at very low levels. If global environmental antibiotic pollution continues, ARG abundance is expected to continue as well. Moreover, our analysis emphasizes the importance of integrating existing information particularly when attempting to describe complex relationships with limited mechanistic understanding. Graphical abstract Unlabelled Image Highlights • Environmental antibiotic pollution has unknown effects on resistance gene levels. • Selective pressure was evaluated in surface waters, sediments and wastewaters. • Gene abundance was correlated with antibiotic pressure using linear mixed-models. • Worldwide resistance gene abundance correlates with antibiotic selective pressure. • Antibiotic pressure and matrix should be considered in resistance risk assessment. [ABSTRACT FROM AUTHOR]

Abstract Twenty-six common ingredients of personal care products (PCPs) in water, sediment and fish from the Evrotas River (Greece) were investigated. Water sample analysis revealed the occurrence of twenty PCPs at concentrations ranging from 2.8 to 2031.0 ng l−1, the maximum corresponding to the endocrine disrupting UV filter benzophenone 3 (BP3). In sediment samples, six compounds were found to be adsorbed, the highest concentration being that of 4-methylbenzylidene camphor (4MBC, 1400.4 ng g−1 dw). Evrotas cyprinid fish (Squalius keadicus) showed a high accumulation potential for these chemicals, 100% detection frequency with maximum concentration that of benzophenone 2 (BP2, 41.9 ng g−1 dw). These data allowed estimating the distribution coefficients sediment-water (DCs-w) and the bioaccumulation factors (BAFs) of the pollutants investigated. Calculated rates revealed that benzophenone 1 (BP1), 4-hydroxybenzophenone (4HB) and ethyl-4-(dimethyl-amino)benzoate (EtPABA) have a strong tendency to adsorb onto the sediments, showing high DCs-w, i.e. 8.2E + 4 l g−1, 6.7E + 4 l g−1 and 5.7E + 3 l g−1, respectively. BFAs were only estimated for 5-methyl benzotriazole (MeBT), the compound having paired data from fish and water. The obtained values (range 2.0E + 2 l g−1–3.8E + 3 l g−1), indicated MeBT's strong bioaccumulation. Risk assessment of the investigated compounds for several aquatic organisms indicated a high ecological risk (HQ > 1) for BP3 and medium ecological risk (HQ ~ 0.5) for ODPABA. Graphical abstract Unlabelled Image Highlights • First determination of 20 personal care product in Evrotas River (Greece) • High levels of UV filters adsorbed onto the river sediments • High bioaccumulation potential of methyl benzotriazole in Squalius keadicus tissues • Eventual ecological risk for BP3 and ODPABA, but generally no hazard [ABSTRACT FROM AUTHOR]

Abstract The transfer of metal and metalloid trace elements (MTEs) from contaminated soil to grapevines is a major issue for grape consumption and for the associated health risks. Based on an isotopic approach, we shed light on the concept of MTE bioavailability. The bioavailable fractions are identified by using the Sr-isotope ratio as a proxy for MTEs. This allows us to differentiate three soil reservoirs: the 'current available fraction' in soil water, the 'reserve available fraction' stored in mineral phases of the soil fractions, and the 'non-available fraction'. The reserve available fraction, representing 10 to 60% of bulk soil depending on the MTE, includes the exchangeable, carbonates, humic substance and oxides fractions. The 87Sr/86Sr isotopic signatures of grape berries and vine leaves show an additional source of MTEs, which is imported by foliar uptake and can contribute up to 10% of the MTEs in leaves. In addition, root-uptake and translocation rates show high accumulation rates of Co, Sn and Cu, and low ones for As, Sb, Zn and Cd. A daily intake between 1 and 3 kg of (dry grapes) would reach the benchmark dose level for a 0.5% (BMDL 0.5). While such a daily intake of grapes is unreasonable, consumption of other local vegetables and fruit would contribute to the daily intake. Hence, a chronic arsenic exposure is of great concern for human health in mining areas. We outline the importance of geochemical tracers, such as Sr isotopes, when determining the transfer and translocation of MTEs in plants. Our method presents a high-precision evaluation of the bioavailability and bioaccumulation of MTEs, and a better understanding of these processes in plants, thus leading to a better assessment of the environmental risk on human health. Graphical abstract Unlabelled Image Highlights • Sr isotopes are a suitable tracer for MTEs and As transfer in grapevine. • Three MTEs and As reservoirs were identified in the studied soil. • The highest MTEs and As concentrations were observed in leaves. • Foliar uptake contributes up to 10% of the MTEs in leaves. • The chronic As exposure is of great concern in the mining areas. [ABSTRACT FROM AUTHOR]

Abstract Climate change and human behaviour, such as building on floodplains, are increasing the incidence of floods in urban areas. This paper investigates the relationship between flood risk and residential accommodation costs, both sales and rental, using a detailed dataset of over 650,000 sale and rental listings in Dublin, Ireland over the period 2006–2015. These are combined with detailed data for the Dodder river on 1% flood risk and past flooding events. Research to date suggested that the lack of a persistent effect may have an impact on buyers' and sellers' risk perceptions by changing with the prevalence of hazard events and that homebuyers are unaware of flood risks and insurance requirements when bidding on properties. Using hedonic regression techniques, the presented work shows opposite results: flood events are found to have a negative impact, particularly on sale prices, while being at 1% risk has no effect once past flood events are controlled for. For past flood events, however, there is evidence to suggest that this impacts on property values, certainly in the areas affected and up to 200 m away. Before the institutional flood risk maps were published, the assessment was based on existing Ordnance Survey maps which showed areas 'Liable to flooding' generated with land surveys carried out around the 1830. Set against these devices for raising awareness of flooding is the Irish constitution which regards property rights almost the same as human rights, which obvious impacts on the ability of planners to implement development/zoning plans. On the basis of this evidence, it is reasonable to conclude that households pay more attention to past flood events than to scientific assessments of flood risk, has important policy implications about communicating flood risk to consumers. Graphical abstract Unlabelled Image Highlights • Analysis on impact of flood risk on rental and sale costs of residential properties in Dublin • Quantitative analysis of impact on prices of perceived and actual flood risk • Use of hedonic regression techniques to account for impacts of amenities on prices • Higher impact of past flood events than scientific assessments of flood risk • Important policy implications about communicating flood risk to consumers [ABSTRACT FROM AUTHOR]

Abstract To investigate halogenated flame retardant (HFR) contents in recycled plastic materials, 23 recycled plastic samples manufactured in five Chinese provinces were randomly purchased online, and the ∑12HFR concentrations of these samples (including 8 polybrominated diphenyl ethers (PBDEs, BDE 28, 47, 99, 100, 154, 153, 183 and 209), decabromodiphenylethane (DBDPE), 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE), and 2 dechlorane plus isomers (DP, syn -DP and anti-DP)) varied from ND to 169,000 ng g−1 (mean ± SD, 46,900 ± 44,700 ng g−1). BDE 209 and DBDPE were the dominant components and their concentration ranges were from ND to 106,000 ng g−1 and ND to 81,900 ng g−1, respectively. Generally, the HFR content and plastic variety closely correlate, and the ∑HFR concentrations in the polyvinyl chloride (PVC, N = 5), polypropylene (PP, N = 9), acrylonitrile butadiene styrene (ABS, N = 5), polystyrene (PS, N = 1) and polyethylene (PE, N = 3) samples were 65,300 ± 42,400, 36,700 ± 56,000, 30,000 ± 25,200, 24,300 and 4330 ± 7500 ng g−1, respectively. The HFR abundance in plastic from Guangdong (76,000 ± 56,400 ng g−1, N = 7) and Hebei (37,500 ± 11,500 ng g−1, N = 4) was much higher than that for other provinces/cities. Graphical abstract Unlabelled Image Highlights • HFR occurrence in recycled plastics in China was reported for the first time. • BDE 209 and DBDPE were the dominant components of the HFRs. • PVC and PP were the most contaminated plastics by HFRs. • Amount of flame retardant residual in recycled plastics were estimated. [ABSTRACT FROM AUTHOR]

Abstract In an attempt to investigate the traffic-impacted vertical aerosols profile and its relationship with potential carcinogenicity and/or mutagenicity, samples of different sized airborne particles were collected in parallel at the 1st and 5th floor of a 19 m high building located next to one of the busiest roads of Athens. The maximum daily concentrations were 65.9, 42.5 and 38.5 μg/m3, for PM 10 , PM 2.5 and PM 1 , respectively. The vertical concentration ratio decreased with increasing height verifying the role of the characteristics of the area (1st/5th floor: 1.21, 1.13, 1.09 for PM 10 , PM 2.5 and PM 1 , respectively). Chemically, strengthening the previous hypothesis, the collected particles were mainly carbonaceous (68%–93%) with the maximum budget of the polyaromatic hydrocarbons being recorded near the surface (1st/5th floor: 1.84, 1.07, 1.15 for PM 10 , PM 2.5 and PM 1 , respectively). The detected PM-bound PAHs along with the elements as well as the carbonaceous and ionic constituents were used in a source apportionment study. Exhaust and non-exhaust emissions, a mixed source of biomass burning and high temperature combustion processes (natural gas, gasoline/diesel engines), sea salt, secondary and soil particles were identified as the major contributing sources to the PM pollution of the investigated area. With respect to the health hazards, the calculation of the Benzo[ a ]Pyrene toxicity equivalency factors underlined the importance of the height of residence in buildings for the level of the exposure (1st/5th floor: B[ a ]P TEQ : 1.82, 1.12, 1.10, B[ a ]P MEQ : 1.85, 1.13, 1.09 for PM 10 , PM 2.5 and PM 1 , respectively). Finally, despite its verified significance as a surrogate compound for the mixture of the hydrocarbons (its contribution up to 72%, 79% on the level of the 1st and 5th floor, respectively), the importance of the incorporation of PAH species in addition to B[ a ]P when assessing PAH toxicity was clearly documented. Graphical abstract Unlabelled Image Highlights • The vertical distance from the street level was determinant. • The maxima of the PM mass, the PAHs and the PM toxicity/mutagenicity occurred near the surface. • OC being followed by EC was the main contributor to the PM mass. • As many as possible PAH species should be incorporated in addition to B[ a ]P when assessing PAH toxicity. • The influence of the anthropogenic input was more pronounced at the smaller fraction. [ABSTRACT FROM AUTHOR]

Abstract This study re-analysed 14 semi-structured interviews with policy officials from the UK Department for Environment, Food and Rural Affairs (Defra) to explore the use of a variety of regulatory instruments and different levels of risk across 14 policy domains and 18 separately named risks. Interviews took place within a policy environment of a better regulation agenda and of broader regulatory reform. Of 619 (n) coded references to 5 categories of regulatory instrument, ‘command and control’ regulation (n = 257) and support mechanisms (n = 118) dominated the discussions, with a preference for ‘command and control’ cited in 8 of the policy domains. A framing analysis revealed officials' views on instrument effectiveness, including for sub-categories of the 5 key instruments. Views were mixed, though notably positive for economic instruments including taxation, fiscal instruments and information provision. An overlap analysis explored officials' mapping of public environmental risks to instrument types suited to their management. While officials frequently cite risk concepts generally within discussions, the extent of overlap for risks of specific significance was low across all risks. Only ‘command and control’ was mapped to risks of moderate significance in likelihood and impact severity. These results show that policy makers still prefer ‘command and control’ approaches when a certainty of outcome is sought and that alternative means are sought for lower risk situations. The detailed reasons for selection, including the mapping of certain instruments to specific risk characteristics, is still developing. Graphical abstract Unlabelled Image Highlights • 14 interviews with policy officials re-analysed instrument selection and environmental risk. • Positive, negative and neutral framings illustrated how instruments were perceived. • Low overlap between instrument category and risk significance suggests other influences in play. • Improved knowledge exchange is recommended for risk analysis and policy communities. [ABSTRACT FROM AUTHOR]

Abstract The Yellow River flows through Lanzhou city and is the only drinking water source for 3.6 million residents. Yet, little is known regarding the safety and quality of the Yellow River for resident consumption. To address this knowledge-gap, water samples were collected from different sites within this section during the dry and wet seasons. Physico-chemical parameters and microbial community metrics were analyzed to assess the health risk associated with this Chinese mother river. Water quality of the river was better during the dry season (March–April) than in the wet season (September–October). Fifteen conventional physico-chemical and biological indices, such as NH 3 -N, NO 2 −-N, total nitrate (TN), five day biochemical oxygen demand (BOD 5), chemical oxygen demand (COD), volatile phenol (VP), and coliform abundances, generally exceeded acceptable standards. The average abundance of coliforms was 2.8 times that of acceptable standards in the dry season and 4.6 times the standards in the wet season. The concentration of the toxic metal As was more than two times than that of the national standard in waters from the wet season. Microbial community analysis also indicated that community diversity and species richness were positively correlated with the concentrations of several physico-chemical parameters. The results indicate that As and Cr6+ pose potential risk for human health through consumption by residents. Further, the results indicated that human activities are the main causes of water pollution, and that long-term strict monitoring should be conducted to ensure the safety of drinking water consumption and the health of the environment. Graphical abstract Unlabelled Image Highlights • Water quality was better in the dry than that in the wet season. • As, Cr6+ and Pb have a potential risk for residents health. • Pathogenic coliform was positive with physico-chemical parameters. • The Yellow River has potential environmental risk. • Strictly environmental policy should be taken for resident health. [ABSTRACT FROM AUTHOR]

Highlights • A study on mitigating cadmium and lead pollution via revegetation was conducted. • Pollutant concentration, phytostabilization, and rainfall impacts were considered. • A combination of herbs, shrubs, and trees was best at containing both heavy metals. Graphical abstract Unlabelled Image Abstract Artificial soil on railway rock-cut slopes may be considerably contaminated with cadmium (Cd) and lead (Pb), which may migrate to nearby croplands and pose substantial risks to human and animal health. We investigate the influence of three types of revegetation modes – herbs (HS); herbs and shrubs (HSS); and herbs, shrubs, and trees (HSTS) – on the transportation of these heavy metals in soils. Six representative rock-cut slopes were chosen, and the vegetation, pollutant concentration, phytostabilization, and simulated rainfall were investigated. The results indicated that Cd posed a considerable ecological risk, while Pb posed a low ecological risk in the artificial soil. The erosion of artificial soil on the slopes played a primary role in the migration of Cd and Pb, because 87–91% of Cd and 85–89% of Pb was lost in sediments. Revegetation modes significantly affected the transportation of Cd and Pb. HSTS controlled a lot of Cd in their dominant plants among the three revegetation modes. HSTS not only decreased enrichment factor (EF) and ecological risk (E r) values of Cd in the soils, but also decreased runoff, sediment and cumulative migrated Cd and Pb. The relationships among multi-factors were analyzed by stepwise mediation effect test and the results indicated that root weight density, aboveground biomass and immobilization of dominant plants for Cd and Pb were important direct factors which influenced the transportation of Cd and Pb. Overall, HSTS has proven to be beneficial in controlling the migration of Cd and Pb to croplands near the slopes and reducing their environmental risk. These results can offer a tested and implementable solution for mitigating the risks posed by these pollutants around the quickly expanding railways in the study region. [ABSTRACT FROM AUTHOR]

In this work, the presence of 20 pharmaceuticals in wastewater from Colombia is investigated. Several widely consumed compounds have been detected in wastewater samples from different origins and geographical areas in Colombia. The studied pharmaceuticals included antibiotics, analgesics and anti-inflammatories, cholesterol lowering statin drugs, lipid regulators, and anti-depressants. The investigated samples were urban wastewater collected during one whole week before (influent) and after treatment (effluent) in the wastewater treatment plants (WWTPs) of Bogotá and Medellin. Raw wastewater from the Hospital of Tumaco and from the city of Florencia were also collected. Analyses performed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) revealed that most of the target analytes were present in all the wastewater samples. The highest concentrations (up to 50 μg/L) corresponded to acetaminophen, but several antibiotics, such as azithromycin, ciprofloxacin and norfloxacin, and antihypertensive drugs, such as losartan and valsartan, were commonly present in influent wastewater (IWW) at levels above 1 μg/L. Moreover, the treatment applied in WWTPs seemed to not efficiently remove the compounds under study, because most pharmaceuticals were also present in effluent wastewater (EWW) at concentrations close to those of the IWW. Special emphasis was made in this work on the quality of data reported, performing a detailed study of quality control (QC) samples. The analytical approach used –direct injection of 5-fold diluted samples without any additional treatment – is simpler and faster than the commonly applied solid phase extraction (SPE). The use of 12 isotope-labelled internal standards ensured the satisfactory correction of matrix effects for the corresponding analytes. For the remaining 8 compounds, no drastic matrix effects were observed, and only four compounds (cloxacillin, doxycycline, losartan, tetracycline) presented QC recoveries near or slightly below 60%, revealing ionization suppression, particularly in the IWW. Data on the occurrence of pharmaceuticals reported in this paper are the basis for current studies that aim to develop efficient systems for the degradation/removal of these compounds from the aquatic environment. [ABSTRACT FROM AUTHOR]

Mounting evidence has demonstrated the combined effects of ocean acidification (OA) and other environmental stressors on marine organisms. Although metal pollution is widely distributed in coasts and estuaries, the combined effects of OA and metal pollution have received little attention until recent years. In this study, the accumulation and subcellular distribution of cadmium (Cd) and the physiological responses of the oyster Crassostrea gigas were investigated after 31 days of exposure to OA and Cd, either alone or in combination. Increased Cd accumulation was found both in gills (about 57% increase at pH 7.8, 22% increase at pH 7.6) and digestive glands (about 38% increase at pH 7.8, 22% increase at pH 7.6) of C . gigas under elevated p CO 2 exposure. Although a similar total Cd accumulation pattern was seen in oyster gills and digestive glands, a higher partition of Cd in the BIM (biologically inactive metal) fractions of gills (about 60%) was found in Cd-exposed treatments compared to the digestive glands (about 45%), which might correspond to the generally lower toxicity in gills. Moreover, synergetic effects of Cd and OA on the oxidative stresses, histopathological damage, and apoptosis of exposed oysters were observed in this study, which might be explained by significant interactions of these two factors on increased generation of ROS. These findings demonstrated that OA could aggravate the toxicity of metals in marine organisms, with significant implications for coastal benthic ecosystems regarding the widespread metal contamination and the concurrent increase of acidified seawater. [ABSTRACT FROM AUTHOR]

Sustainable flood management is a basic societal need. In this article, life cycle assessment is used to compare two ways to maintain the state of a coastal urban area in a changing climate with increasing flood risk. On one side, the construction of a dike, a hard and proactive scenario, is modelled using a bottom up approach. On the other, the systematic repair of houses flooded by sea surges, a post-disaster measure, is assessed using a Monte Carlo simulation allowing for aleatory uncertainties in predicting future sea level rise and occurrences of extreme events. Two metrics are identified, normalized mean impacts and probability of dike being most efficient. The methodology is applied to three case studies in Denmark representing three contrasting areas, Copenhagen, Frederiksværk, and Esbjerg. For all case studies the distribution of the calculated impact of repairing houses is highly right skewed, which in some cases has implications for the comparative LCA. The results show that, in Copenhagen, the scenario of the dike is overwhelmingly favorable for the environment, with a 43 times higher impact for repairing houses and only 0% probability of the repairs being favorable. For Frederiksværk and Esbjerg the corresponding numbers are 5 and 0.9 times and 85% and 32%, respectively. Hence constructing a dike at this point in time is highly recommended in Copenhagen, preferable in Frederiksværk, and probably not recommendable in Esbjerg. [ABSTRACT FROM AUTHOR]

Organophosphate ester (OPE) flame retardants and plasticizers have been detected at generally high frequencies (70–98%) for the first time in the atmosphere over the NW African coastal Mediterranean. Results from sixty air samples (total suspended particles, TSP) collected between March 2015 and January 2016 in an urban coastal site (Bizerte, Tunisia) revealed ∑ 9 OPE concentrations of ~100–1060 pg m −3 (470 pg m −3 , median) with TCPPs, EHDPP and TiBP exhibiting the higher median concentrations (~110, 100 and 85 pg m −3 , respectively). Spring generally exhibited the lowest concentrations, probably linked to the influence of local meteorological conditions and air mass trajectories to a lesser extent. Non-chlorinated OPEs generally predominated, in contrast to the most common reported situation in marine environments (i.e. higher abundance of chlorinated OPEs) pointing to the relevance of local OPE sources in the study area. TiBP levels were generally higher than those reported for other marine/coastal environments suggesting this OPE as a good tracer of local sources in Bizerte. Contrarily, the atmospheric levels of other abundant OPEs in the area (e.g. TCPP) seem to be in the range and/or lower than those reported for remote marine environments. These findings point to the interplay of different factors with solar irradiance (potentially enhancing atmospheric photochemical oxidation reactions) and meteorological conditions in the study area likely compensating potential local sources of some OPEs. Not all OPEs presented the same seasonality in terms of atmospheric concentrations and pattern. The estimated atmospheric dry deposition fluxes (∑ 9 OPEs) were 18–180 ng m −2  d −1 . Up to ~9 kg y −1 of OPEs (~1 kg y −1 of new organic anthropogenic phosphorus coming from OPEs) can be loaded to the shallow and enclosed Bizerte lagoon (~130 km 2 ), considered as the most important aquaculture area in Tunisia, with yet unknown implications for the environmental exposure and impacts in the ecosystem functioning. [ABSTRACT FROM AUTHOR]

A comprehensive and fact-based risk assessment of heavy metals in soils is paramount for defining strategies for environmental management. However, the risk assessment approaches of heavy metals in soils are often incomplete, in particular, causation-based pollution source apportionment is absent at present. Here, we developed a causation-based method framework of an integrated risk assessment of soil heavy metals. This method framework involves risk identification, causation-based source apportionment and an environmental sensitivity assessment. Dongtang Township in Guangdong Province, China was used as a case study. We found that air Cd, the background value and metallurgical industries (Danxia and Fankou plants) were identified as the major causes of soil Cd, and air and soil Cd as well as water Cd interacted causally. Danxia and Fankou plants, the mining area and background value were the major causes of soil Pb. The risk level and environmental sensitivity of the Danxia and Fankou plants were assessed. This is the first study to establish a causation-based method framework of an integrated risk assessment of soil heavy metals. This framework promotes systematic integration of risk assessment of soil heavy metals and expands traditional research on pollution source apportionment from a correlation-based approach to crucial insights into causation. [ABSTRACT FROM AUTHOR]

With increasing consumption of Vegetables planted in Plastic Greenhouses (VPGs) in China, phthalate exposure from VPGs represents an overlooked source of total daily exposure, since VPGs are not included in current phthalate exposure scenarios. For this reason, current exposure scenario modeling may underestimate the daily phthalate exposure in relation to adverse health impacts. Thus, in this paper we estimated the oral intake exposure to phthalates from VPGs by studying four provinces ranging from the north to the south in eastern China, based on published data. Exposures to di(2-ethylhexyl)-phthalate (DEHP) and dibutyl phthalate (DBP) were assessed for various population groups differentiated by age, sex, income, and region. Younger children experienced the highest exposure from VPG intake (mean 1.55 (0.19 and 6.20) (2.5th and 97.5th percentiles) μg/kg/body weight (bw)/day), followed by older children, teenagers, and adults (0.53 (0.06 and 1.80)). Exposures in urban populations were significantly higher than those in rural areas, and when examined by income, urban populations with low-income had the lowest exposures and the upper-middle income group was associated with the highest levels. Exposures in northeastern and southern provinces were higher than the levels in middle provinces due to regional disparities in dietary habits. Proportions of the mean oral intake exposures to DEHP and DBP from VPGs to the total daily exposure by modeling different exposure pathways and media were over 10% for all age groups. The DEHP and DBP exposure from VPG intake in China were found to be much higher than the levels in western countries. For example, exposures of older children to DBP and DEHP were respectively 17 and 4 times higher than European levels. The authors recommend policy interventions to protect populations from future risk of phthalate exposure. [ABSTRACT FROM AUTHOR]

Recent years have witnessed increases in emissions and environmental contamination by F-53B, a chlorinated polyfluorinated ether sulfonate used as a mist suppressant in the Chinese electroplating industry. In this study, based on a national industrial survey and statistics, we estimated the annual release of F-53B across China during the period 2006–2015. We evaluated the global transport and distribution of F-53B using the Globo-POP model, and assessed its environmental risk in regions of China using the EUSES model. Our calculations indicate that approximately 10–14 metric tons (t) of F-53B are released annually into the environment, mainly in East China. Our Globo-POP calculations demonstrate that a limited fraction (0.02–0.50%) of the cumulative F-53B emissions can reach the Arctic via oceanic advection. Despite its low long-range transport potential, F-53B can accumulate in Chinese local waters. Our EUSES calculations predict that the F-53B concentration in fresh water (South China) currently approaches 0.7 mg/L and will reach 2.3 mg/L by 2020 in the region surrounding chromium-plating plants if its use remains uncontrolled. Such an increase in concentration implies a potential risk to aquatic environments. This study highlights the risk if F-53B is proposed to be used as a substitute for perfluorooctanesulfonic salt-based mist suppressants. [ABSTRACT FROM AUTHOR]

Wind-driven rain (WDR) is rain given a horizontal velocity component by wind and falling obliquely. It is a prominent environmental risk to built heritage, as it contributes to the damage of porous building materials and building element failure. While predicted climate trends are well-established, how they will specifically manifest in future WDR is uncertain. This paper combines UKCP09 Weather Generator predictions with a probabilistic process to create hourly time series of climate parameters under a high-emissions scenario for 2070–2099 at eight UK sites. Exposure to WDR at these sites for baseline and future periods is calculated from semi-empirical models based on long-term hourly meteorological data using ISO 15927-3:2009. Towards the end of the twenty-first century, it is predicted that rain spells will have higher volumes, i.e. a higher quantity of water will impact façades, across all 8 sites. Although the average number of spells is predicted to remain constant, they will be shorter with longer of periods of time between them and more intense with wind-driven rain occurring for a greater proportion of hours within them. It is likely that in this scenario building element failure – such as moisture ingress through cracks and gutter over-spill – will occur more frequently. There will be higher rates of moisture cycling and enhanced deep-seated wetting. These predicted changes require new metrics for wind-driven rain to be developed, so that future impacts can be managed effectively and efficiently. [ABSTRACT FROM AUTHOR]

The cultivation of genetically modified (GM) crops has raised many questions regarding their environmental risks, particularly about their ecological impact on non-target organisms, such as their closely-related relative species. Although evaluations of transgene flow from GM crops to their conventional crops has been conducted under large-scale farming system worldwide, in particular in North America and Australia, few studies have been conducted under smallholder farming systems in Asia with diverse crops in co-existence. A two-year field study was conducted to assess the potential environmental risks of gene flow from glufosinate-ammonium resistant (GR) Brassica napus to its conventional relatives, B. napus , B. juncea , and Raphanus sativus under simulated smallholder field conditions in Korea. Herbicide resistance and simple sequence repeat (SSR) markers were used to identify the hybrids. Hybridization frequency of B. napus  × GR B. napus was 2.33% at a 2 m distance, which decreased to 0.007% at 75 m. For B. juncea , it was 0.076% at 2 m and decreased to 0.025% at 16 m. No gene flow was observed to R. sativus . The log-logistic model described hybridization frequency with increasing distance from GR B. napus to B. napus and B. juncea and predicted that the effective isolation distances for 0.01% gene flow from GR B. napus to B. napus and B. juncea were 122.5 and 23.7 m, respectively. Results suggest that long-distance gene flow from GR B. napus to B. napus and B. juncea is unlikely, but gene flow can potentially occur between adjacent fields where the smallholder farming systems exist. [ABSTRACT FROM AUTHOR]

Due to their pseudo-persistence and their biological activity, pharmaceuticals are emerging contaminants of major concern for the environment. The aim of this review is to provide an updated inventory of the contamination of aquatic environments by 43 drugs representing different classes of pharmaceuticals, such as antibiotics, anti-inflammatory drugs, anti-depressants, sex hormones, lipid regulators and beta-blockers. The data collected is focused on contamination levels reported in marine coastal waters and in waste and river waters flowing into the Mediterranean Sea. The most widely produced/prescribed classes of medicines are compared with the substances most widely searched for in the environment. Ranges of pollution levels according to the type of water body are also presented, to examine the fate in sewage treatment plants and the persistence in the environment of the targeted molecules. Levels of pharmaceuticals ranged from 100 to 10,000 or even 100,000 ng·L −1 in sewage waters, dropping to 1 to 10,000 ng·L −1 in rivers and to not detected to 3000 ng·L −1 in sea water. However, this paper evidences a lack of data for seawater and also for several countries along the southern coast of the Mediterranean Sea. In order to assess the risk for aquatic ecosystems associated with pharmaceuticals, experimental ecotoxicological values obtained using normalized acute and/or chronic bioassays carried out with different trophic levels were collected for each drug. Targeted biological species and associated bioassays are classified on the basis of their sensitivity to each class of compounds. Occurrence and ecotoxicology are then linked by using the Hazard Quotient (HQ) to assess the environmental risk caused by pharmaceuticals in the Mediterranean Basin. Correlations between HQ and frequency of detection of pharmaceuticals highlighted thirteen compounds that are cause for concern in Mediterranean fresh and sea waters, such as 17α-ethinylestradiol, metoprolol, 8 antibiotics and 3 analgesics/anti-inflammatories. [ABSTRACT FROM AUTHOR]

Coastal river deltas are hotspots of global change impacts. Sustainable delta futures are increasingly threatened due to rising hazard exposure combined with high vulnerabilities of deltaic social-ecological systems. While the need for integrated multi-hazard approaches has been clearly articulated, studies on vulnerability and risk in deltas either focus on local case studies or single hazards and do not apply a social-ecological systems perspective. As a result, vulnerabilities and risks in areas with strong social and ecological coupling, such as coastal deltas, are not fully understood and the identification of risk reduction and adaptation strategies are often based on incomplete assumptions. To overcome these limitations, we propose an innovative modular indicator library-based approach for the assessment of multi-hazard risk of social-ecological systems across and within coastal deltas globally, and apply it to the Amazon, Ganges-Brahmaputra-Meghna (GBM), and Mekong deltas. Results show that multi-hazard risk is highest in the GBM delta and lowest in the Amazon delta. The analysis reveals major differences between social and environmental vulnerability across the three deltas, notably in the Mekong and the GBM deltas where environmental vulnerability is significantly higher than social vulnerability. Hotspots and drivers of risk vary spatially, thus calling for spatially targeted risk reduction and adaptation strategies within the deltas. Ecosystems have been identified as both an important element at risk as well as an entry point for risk reduction and adaptation strategies. [ABSTRACT FROM AUTHOR]

There is a lack of knowledge on the effects of biochar (BC) on the release dynamics of potentially toxic elements (PTEs) in different phases of soil under systematic change of redox potential (E H ). We aimed to elucidate the impact of pre-definite E H on the release dynamics of dissolved and colloidal concentrations of Cd, Cu, Ni, and Zn as well as their phytoavailability and potential mobility in the solid-phase of a mining soil treated with rice hull biochar (S + BC) compared to non-treated soil (S). The influence of E H -dependent changes of soil pH, dissolved organic carbon (DOC), dissolved aromatic carbon (DAC), Fe, Mn, SO 4 2 − , and Cl − on the elements release was also determined. The experiment was conducted stepwise from reducing (− 30 mV in S and − 12 mV in S + BC) to oxidizing (+ 218 mV in S and + 333 mV in S + BC) conditions using an automated biogeochemical microcosm system. Biochar-treated soil exhibited a wider range of E H and a lower pH than the non-treated soil. Dissolved concentrations of Cd, Cu, Ni, Zn, Fe, Mn, SO 4 2 − , and DAC increased under oxic conditions in the non-treated and biochar-treated-soils, which might be due to the decline of pH, and/or sulfide oxidation. Cadmium was more abundant in the colloidal fraction, while Cu, Mn, and DOC were more abundant in the dissolved fraction. Nickel, Zn, and Fe distributed almost equally in both fractions. Biochar increased the dissolved concentration of Cd, Ni, Zn and in particular Cu under oxic conditions. However, the biochar did not significantly affect the colloidal fraction of Cd, Cu, Ni, and Zn. The phytoavailability of the studied elements was higher than the potential mobility. We conclude that increasing the dissolved concentrations of the elements under oxic conditions might increase their release and transfer into the groundwater and the food chain which should be harmful for the environment. [ABSTRACT FROM AUTHOR]

Aquatic ecotoxicity assays used to assess ecological risk assume that organisms living in a contaminated habitat are forcedly exposed to the contamination. This assumption neglects the ability of organisms to detect and avoid contamination by moving towards less disturbed habitats, as long as connectivity exists. In fluvial systems, many environmental parameters vary spatially and thus condition organisms' habitat selection. We assessed the preference of zebra fish ( Danio rerio ) when exposed to water samples from two western Ecuadorian rivers with apparently distinct disturbance levels: Pescadillo River (highly disturbed) and Oro River (moderately disturbed). Using a non-forced exposure system in which water samples from each river were arranged according to their spatial sequence in the field and connected to allow individuals to move freely among samples, we assayed habitat selection by D . rerio to assess environmental disturbance in the two rivers. Fish exposed to Pescadillo River samples preferred downstream samples near the confluence zone with the Oro River. Fish exposed to Oro River samples preferred upstream waters. When exposed to samples from both rivers simultaneously, fish exhibited the same pattern of habitat selection by preferring the Oro River samples. Given that the rivers are connected, preference for the Oro River enabled us to predict a depression in fish populations in the Pescadillo River. Although these findings indicate higher disturbance levels in the Pescadillo River, none of the physical-chemical variables measured was significantly correlated with the preference pattern towards the Oro River. Non-linear spatial patterns of habitat preference suggest that other environmental parameters like urban or agricultural contaminants play an important role in the model organism's habitat selection in these rivers. The non-forced exposure system represents a habitat selection-based approach that can serve as a valuable tool to unravel the factors that dictate organisms' spatial distribution in connected ecosystems. [ABSTRACT FROM AUTHOR]

Overland transport of ore concentrate from the Red Dog lead/zinc mine in northwest Alaska to its seaport has historically raised concerns among local subsistence users regarding the potential impacts of fugitive dust from the operation, including the potential uptake of metals into caribou meat. Caribou are an integral part of life for northern Alaska Natives for both subsistence and cultural reasons. The Western Arctic caribou herd, whose range includes the Red Dog mine, transportation corridor, and port site, sometimes overwinter in the vicinity of mine operations. A weight of evidence approach using multiple lines of evidence was used to evaluate potential risks associated with subsistence consumption of caribou harvested near the road and mine. Data from a long-term caribou monitoring program indicate a lack of consistent trends for either increasing or decreasing metals concentrations in caribou muscle, liver, and kidney tissue. Lead, cadmium, and zinc from all tissues were within the range of reference concentrations reported for caribou elsewhere in Northern Alaska. In addition, a site use study based on data from satellite-collared caribou from the Western Arctic Herd showed that caribou utilize the area near the road, port, and mine approximately 1/20 th to 1/90 th of the time assumed in a human health risk assessment conducted for the site, implying that risks were significantly overestimated in the risk assessment. The results from multiple lines of evidence consistently indicate that fugitive dust emissions from Red Dog Operations are not a significant source of metals in caribou, and that caribou remain safe for human consumption. [ABSTRACT FROM AUTHOR]

The temporal irregularity of rainfall, characteristic of a Mediterranean climate, corresponds to the irregularity of the environmental effects on soil. We used aggressiveness as an indicator to quantify the potential environmental impact of rainfall. However, quantifying rainfall aggressiveness is conditioned by the lack of sub-hourly frequency records on which intensity models are based. On the other hand, volume models are characterized by a lack of precision in the treatment of heavy rainfall events because they are based on monthly series. Therefore, in this study, we propose a new methodology for estimating rainfall aggressiveness risk. A new synthesis parameter based on reformulation using daily data of the Modified Fournier and Oliver's Precipitation Concentration indices is defined. The weighting of both indices for calculating the aggressiveness risk is established by multiple regression with respect to the local erosion R factor estimated in the last decades. We concluded that the proposed methodology overcomes the previously mentioned limitations of the traditional intensity and volume models and provides accurate information; therefore, it is appropriate for determining potential rainfall impact over long time periods. Specifically, we applied this methodology to the daily rainfall time series from the San Fernando Observatory (1870–2010) in southwest Europe. An interannual aggressiveness risk series was generated, which allowed analysis of its evolution and determination of the temporal variability. The results imply that environmental management can use data from long-term historical series as a reference for decision making. [ABSTRACT FROM AUTHOR]