1. Benzene exposure induces gut microbiota dysbiosis and metabolic disorder in mice
- Author
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Yunqiu Pu, Lihong Yin, Shuangbin Ji, Yuepu Pu, Jiahui Ji, Rongli Sun, Minjian Chen, Zhaodi Man, Kai Xu, and Juan Zhang
- Subjects
Environmental Engineering ,010504 meteorology & atmospheric sciences ,Arginine ,010501 environmental sciences ,Steroid biosynthesis ,Gut flora ,01 natural sciences ,Microbiology ,Mice ,RNA, Ribosomal, 16S ,White blood cell ,medicine ,Animals ,Environmental Chemistry ,Waste Management and Disposal ,0105 earth and related environmental sciences ,biology ,Chemistry ,Metabolic disorder ,Benzene ,Metabolism ,medicine.disease ,biology.organism_classification ,Pollution ,Gastrointestinal Microbiome ,Mice, Inbred C57BL ,Red blood cell ,medicine.anatomical_structure ,Liver ,Dysbiosis - Abstract
The gut microbiota comprises a multispecies microbial community and is essential for maintaining health. Benzene is a widespread environmental and occupational pollutant that mainly causes blood and bone marrow abnormalities. However, the effects of benzene on gut microbiota and metabolism have not yet been investigated. In this study, C57BL/6 mice were exposed to 0, 6, 30 and 150 mg/kg benzene by subcutaneous injection for 30 days. We observed that white blood cell levels significantly decreased in the three benzene exposure groups, while red blood cell and hemoglobin levels were only changed remarkably in 30 and 150 mg/kg benzene-treated mice. The results of 16S rRNA sequencing showed that benzene exposure altered the overall structure of the gut microbial communities. In addition, significant enrichments of Actinobacteria (p
- Published
- 2020
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