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11 results on '"Tao, Meng"'

7. Ultrafine CB-induced small airway obstruction in CB-exposed workers and mice

Author

Yuxin Zheng, Mo Yang, Yanting Li, Liping Zhang, Weimin Gao, Michael S. Bloom, Guang-Hui Dong, Tao Meng, Yong Niu, and Yufei Dai

Subjects
Male, Pathology, medicine.medical_specialty, Environmental Engineering, 010504 meteorology & atmospheric sciences, 010501 environmental sciences, 01 natural sciences, Pulmonary function testing, Mice, FEV1/FVC ratio, Soot, Occupational Exposure, medicine, Animals, Humans, Environmental Chemistry, Lung, Waste Management and Disposal, 0105 earth and related environmental sciences, Inhalation exposure, Air Pollutants, Inhalation Exposure, business.industry, Airway obstruction, medicine.disease, Pollution, Respiratory Function Tests, Airway Obstruction, Mice, Inbred C57BL, Male workers, Immunohistochemistry, business, Airway, Target organ
Abstract

The potential threat of superfine carbon black (CB) particles to human health has received attention, but there are few human toxicological data available. The purpose of this study was to investigate the relationships between serum CC16 and SP-A with small airway related pulmonary functions in CB workers. Ninety-nine male CB packers and 115 non-CB-exposed healthy male workers were recruited. Serum CC16 and/or SP-A and pulmonary function tests were evaluated, and the relationship between them were also analyzed. To further assess pulmonary damage induced by CB particles in target organs, an animal inhalation exposure study was conducted. Male C57BL/6 mice were exposed to 15 and 30 mg/m3 CB for 6 h per day for 28 days. Levels of CC16 and SP-A were evaluated by ELISA and immunohistochemical staining (IHC). The results showed a 20% decreased in median CC16 and a 15% increase in median SP-A among CB-exposed workers. FEV1%, FEV/FVC, MMEF%, FEF25%, and FEF75% were also decreased in CB-exposed workers (P

Published
2019

11. Increased levels of etheno-DNA adducts and genotoxicity biomarkers of long-term exposure to pure diesel engine exhaust

Author

Yufei Dai, Xiao Zhang, Yong Niu, Yuxin Zheng, Ping Bin, Tao Meng, Guizhen Gu, Weimin Gao, Shanfa Yu, Xin Sun, Huawei Duan, Haibin Li, and Meili Shen

Subjects
Adult, Male, 0301 basic medicine, Environmental Engineering, DNA damage, Population, medicine.disease_cause, Andrology, DNA Adducts, 03 medical and health sciences, 0302 clinical medicine, Air Pollution, Occupational Exposure, medicine, Humans, Environmental Chemistry, Polycyclic Aromatic Hydrocarbons, education, Waste Management and Disposal, Chromatography, High Pressure Liquid, Vehicle Emissions, Inhalation exposure, Air Pollutants, Inhalation Exposure, education.field_of_study, Micronucleus Tests, Chemistry, DNA, Pollution, Comet assay, Oxidative Stress, 030104 developmental biology, 030220 oncology & carcinogenesis, Environmental chemistry, Micronucleus test, Female, Comet Assay, Micronucleus, Biomarkers, Genotoxicity, Oxidative stress, DNA Damage
Abstract

Etheno-DNA adducts are biomarkers for assessing oxidative stress. In this study, the aim was to detect the level of etheno-DNA adducts and explore the relationship between the etheno-DNA adducts and genotoxicity biomarkers of the diesel engine exhaust (DEE)-exposed workers. We recruited 86 diesel engine testing workers with long-term exposure to DEE and 99 non-DEE-exposed workers. The urinary mono-hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) and etheno-DNA adducts (edA and edC) were detected by HPLC-MS/MS and UPLC-MS/MS, respectively. Genotoxicity biomarkers were also evaluated by comet assay and cytokinesis-block micronucleus assay. The results showed that urinary edA was significantly higher in the DEE-exposed workers (p

Published
2016

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