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12 results on '"Haynes, Barton F"'

1. Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide

Author

Alam, S. Munir, Aussedat, Baptiste, Vohra, Yusuf, Ryan Meyerhoff, R., Cale, Evan M., Walkowicz, William E., Radakovich, Nathan A., Anasti, Kara, Armand, Lawrence, Parks, Robert, Sutherland, Laura, Scearce, Richard, Joyce, M. Gordon, Pancera, Marie, Druz, Aliaksandr, Georgiev, Ivelin S., Von Holle, Tarra, Eaton, Amanda, Fox, Christopher, Reed, Steven G., Louder, Mark, Bailer, Robert T., Morris, Lynn, Abdool-Karim, Salim S., Cohen, Myron, Liao, Hua-Xin, Montefiori, David C., Park, Peter K., Fernández-Tejada, Alberto, Wiehe, Kevin, Santra, Sampa, Kepler, Thomas B., Saunders, Kevin O., Sodroski, Joseph, Kwong, Peter D., Mascola, John R., Bonsignori, Mattia, Moody, M. Anthony, Danishefsky, Samuel, and Haynes, Barton F. more...

Published
2017
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2. Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies

Author

Bonsignori, Mattia, Kreider, Edward F., Fera, Daniela, Meyerhoff, R. Ryan, Bradley, Todd, Wiehe, Kevin, Alam, S. Munir, Aussedat, Baptiste, Walkowicz, William E., Hwang, Kwan-Ki, Saunders, Kevin O., Zhang, Ruijun, Gladden, Morgan A., Monroe, Anthony, Kumar, Amit, Xia, Shi-Mao, Cooper, Melissa, Louder, Mark K., McKee, Krisha, Bailer, Robert T., Pier, Brendan W., Jette, Claudia A., Kelsoe, Garnett, Williams, Wilton B., Morris, Lynn, Kappes, John, Wagh, Kshitij, Kamanga, Gift, Cohen, Myron S., Hraber, Peter T., Montefiori, David C., Trama, Ashley, Liao, Hua-Xin, Kepler, Thomas B., Moody, M. Anthony, Gao, Feng, Danishefsky, Samuel J., Mascola, John R., Shaw, George M., Hahn, Beatrice H., Harrison, Stephen C., Korber, Bette T., and Haynes, Barton F. more...

Published
2017
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3. Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection

Author

Saunders, Kevin O., primary, Edwards, Robert J., additional, Tilahun, Kedamawit, additional, Manne, Kartik, additional, Lu, Xiaozhi, additional, Cain, Derek W., additional, Wiehe, Kevin, additional, Williams, Wilton B., additional, Mansouri, Katayoun, additional, Hernandez, Giovanna E., additional, Sutherland, Laura, additional, Scearce, Richard, additional, Parks, Robert, additional, Barr, Maggie, additional, DeMarco, Todd, additional, Eater, Chloe M., additional, Eaton, Amanda, additional, Morton, Georgeanna, additional, Mildenberg, Benjamin, additional, Wang, Yunfei, additional, Rountree, R. Wes, additional, Tomai, Mark A., additional, Fox, Christopher B., additional, Moody, M. Anthony, additional, Alam, S. Munir, additional, Santra, Sampa, additional, Lewis, Mark G., additional, Denny, Thomas N., additional, Shaw, George M., additional, Montefiori, David C., additional, Acharya, Priyamvada, additional, and Haynes, Barton F., additional more...

Published
2022
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4. A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice

Author

Martinez, David R., primary, Schäfer, Alexandra, additional, Gobeil, Sophie, additional, Li, Dapeng, additional, De la Cruz, Gabriela, additional, Parks, Robert, additional, Lu, Xiaozhi, additional, Barr, Maggie, additional, Stalls, Victoria, additional, Janowska, Katarzyna, additional, Beaudoin, Esther, additional, Manne, Kartik, additional, Mansouri, Katayoun, additional, Edwards, Robert J., additional, Cronin, Kenneth, additional, Yount, Boyd, additional, Anasti, Kara, additional, Montgomery, Stephanie A., additional, Tang, Juanjie, additional, Golding, Hana, additional, Shen, Shaunna, additional, Zhou, Tongqing, additional, Kwong, Peter D., additional, Graham, Barney S., additional, Mascola, John R., additional, Montefiori, David C., additional, Alam, S. Munir, additional, Sempowski, Gregory, additional, Sempowski, Gregory D., additional, Khurana, Surender, additional, Wiehe, Kevin, additional, Saunders, Kevin O., additional, Acharya, Priyamvada, additional, Haynes, Barton F., additional, and Baric, Ralph S., additional more...

Published
2022
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5. Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates

Author

Francica, Joseph R., primary, Flynn, Barbara J., additional, Foulds, Kathryn E., additional, Noe, Amy T., additional, Werner, Anne P., additional, Moore, Ian N., additional, Gagne, Matthew, additional, Johnston, Timothy S., additional, Tucker, Courtney, additional, Davis, Rachel L., additional, Flach, Britta, additional, O’Connell, Sarah, additional, Andrew, Shayne F., additional, Lamb, Evan, additional, Flebbe, Dillon R., additional, Nurmukhambetova, Saule T., additional, Donaldson, Mitzi M., additional, Todd, John-Paul M., additional, Zhu, Alex Lee, additional, Atyeo, Caroline, additional, Fischinger, Stephanie, additional, Gorman, Matthew J, additional, Shin, Sally, additional, Edara, Venkata Viswanadh, additional, Floyd, Katharine, additional, Lai, Lilin, additional, Boyoglu-Barnum, Seyhan, additional, Van De Wetering, Renee, additional, Tylor, Alida, additional, McCarthy, Elizabeth, additional, Lecouturier, Valerie, additional, Ruiz, Sophie, additional, Berry, Catherine, additional, Tibbitts, Timothy, additional, Andersen, Hanne, additional, Cook, Anthony, additional, Dodson, Alan, additional, Pessaint, Laurent, additional, Van Ry, Alex, additional, Koutsoukos, Marguerite, additional, Gutzeit, Cindy, additional, Teng, I.-Ting, additional, Zhou, Tongqing, additional, Li, Dapeng, additional, Haynes, Barton F., additional, Kwong, Peter D., additional, McDermott, Adrian, additional, Lewis, Mark G., additional, Fu, Tong Ming, additional, Chicz, Roman, additional, van der Most, Robbert, additional, Corbett, Kizzmekia S., additional, Suthar, Mehul S., additional, Alter, Galit, additional, Roederer, Mario, additional, Sullivan, Nancy J., additional, Douek, Daniel C., additional, Graham, Barney S., additional, Casimiro, Danilo, additional, and Seder, Robert A., additional more...

Published
2021
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6. An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations

Author

Swanson, Olivia M., Zhang, Qianyi E., Van Itallie, Elizabeth, Tian, Ming, Brown, Alecia R., Harris, Caitlin, Kapingidza, Anyway Brenda, Rhodes, Brianna, Smith, Lena M., Venkatayogi, Sravani, Cronin, Kenneth, Frazier, McKenzie, Parks, Rob, Bar, Maggie, Jiang, Chuancang, Martin Beem, Joshua S., Cheng, Hwei-Ling, Davis, Jillian, McGovern, Kelly, Newman, Amanda, Edwards, Robert J., Cain, Derek, Alam, S. Munir, Wiehe, Kevin, Saunders, Kevin O., Acharya, Priyamvada, Alt, Fred, Haynes, Barton F., and Azoitei, Mihai L. more...

Abstract

Elicitation of HIV broadly neutralizing antibodies (bnAbs) by vaccination first requires the activation of diverse precursors, followed by successive boosts that guide these responses to enhanced breadth through the acquisition of somatic mutations. Because HIV bnAbs contain mutations in their B cell receptors (BCRs) that are rarely generated during conventional B cell maturation, HIV vaccine immunogens must robustly engage and expand B cells with BCRs that contain these improbable mutations. Here, we engineered an immunogen that activates diverse precursors of an HIV V3-glycan bnAb and promotes their acquisition of a functionally critical improbable mutation. This immunogen was validated biochemically, structurally, and in three different humanized immunoglobulin mouse models that were designed to test HIV immunogens. These results provide a blueprint for rationally designing priming immunogens that explicitly target the elicitation of antibodies with functional yet improbable mutations. more...

Published
2025
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7. Prospects for a safe COVID-19 vaccine

Author

Haynes, Barton F., primary, Corey, Lawrence, additional, Fernandes, Prabhavathi, additional, Gilbert, Peter B., additional, Hotez, Peter J., additional, Rao, Srinivas, additional, Santos, Michael R., additional, Schuitemaker, Hanneke, additional, Watson, Michael, additional, and Arvin, Ann, additional more...

Published
2020
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9. Initiation of immune tolerance–controlled HIV gp41 neutralizing B cell lineages

Author

Zhang, Ruijun, primary, Verkoczy, Laurent, additional, Wiehe, Kevin, additional, Munir Alam, S., additional, Nicely, Nathan I., additional, Santra, Sampa, additional, Bradley, Todd, additional, Pemble, Charles W., additional, Zhang, Jinsong, additional, Gao, Feng, additional, Montefiori, David C., additional, Bouton-Verville, Hilary, additional, Kelsoe, Garnett, additional, Larimore, Kevin, additional, Greenberg, Phillip D., additional, Parks, Robert, additional, Foulger, Andrew, additional, Peel, Jessica N., additional, Luo, Kan, additional, Lu, Xiaozhi, additional, Trama, Ashley M., additional, Vandergrift, Nathan, additional, Tomaras, Georgia D., additional, Kepler, Thomas B., additional, Moody, M. Anthony, additional, Liao, Hua-Xin, additional, and Haynes, Barton F., additional more...

Published
2016
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11. Vaccine-Induced Env V1-V2 IgG3 Correlates with Lower HIV-1 Infection Risk and Declines Soon After Vaccination

Author

Yates, Nicole L., primary, Liao, Hua-Xin, additional, Fong, Youyi, additional, deCamp, Allan, additional, Vandergrift, Nathan A., additional, Williams, William T., additional, Alam, S. Munir, additional, Ferrari, Guido, additional, Yang, Zhi-yong, additional, Seaton, Kelly E., additional, Berman, Phillip W., additional, Alpert, Michael D., additional, Evans, David T., additional, O’Connell, Robert J., additional, Francis, Donald, additional, Sinangil, Faruk, additional, Lee, Carter, additional, Nitayaphan, Sorachai, additional, Rerks-Ngarm, Supachai, additional, Kaewkungwal, Jaranit, additional, Pitisuttithum, Punnee, additional, Tartaglia, James, additional, Pinter, Abraham, additional, Zolla-Pazner, Susan, additional, Gilbert, Peter B., additional, Nabel, Gary J., additional, Michael, Nelson L., additional, Kim, Jerome H., additional, Montefiori, David C., additional, Haynes, Barton F., additional, and Tomaras, Georgia D., additional more...

Published
2014
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12. HIV-1 Vaccines and Adaptive Trial Designs

Author

Corey, Lawrence, primary, Nabel, Gary J., additional, Dieffenbach, Carl, additional, Gilbert, Peter, additional, Haynes, Barton F., additional, Johnston, Margaret, additional, Kublin, James, additional, Lane, H. Clifford, additional, Pantaleo, Giuseppe, additional, Picker, Louis J., additional, and Fauci, Anthony S., additional more...

Published
2011
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