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Your search keyword '"Herbert, Andrew S."' showing total 4 results
Start Over Author "Herbert, Andrew S." Journal science translational medicine
4 results on '"Herbert, Andrew S."'

1. Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses

Author

Mittler, Eva, primary, Wec, Anna Z., additional, Tynell, Janne, additional, Guardado-Calvo, Pablo, additional, Wigren-Byström, Julia, additional, Polanco, Laura C., additional, O’Brien, Cecilia M., additional, Slough, Megan M., additional, Abelson, Dafna M., additional, Serris, Alexandra, additional, Sakharkar, Mrunal, additional, Pehau-Arnaudet, Gerard, additional, Bakken, Russell R., additional, Geoghegan, James C., additional, Jangra, Rohit K., additional, Keller, Markus, additional, Zeitlin, Larry, additional, Vapalahti, Olli, additional, Ulrich, Rainer G., additional, Bornholdt, Zachary A., additional, Ahlm, Clas, additional, Rey, Felix A., additional, Dye, John M., additional, Bradfute, Steven B., additional, Strandin, Tomas, additional, Herbert, Andrew S., additional, Forsell, Mattias N. E., additional, Walker, Laura M., additional, and Chandran, Kartik, additional

Published
2022
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2. The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans

Author

Loo, Yueh-Ming, primary, McTamney, Patrick M., additional, Arends, Rosalinda H., additional, Abram, Michael E., additional, Aksyuk, Anastasia A., additional, Diallo, Seme, additional, Flores, Daniel J., additional, Kelly, Elizabeth J., additional, Ren, Kuishu, additional, Roque, Richard, additional, Rosenthal, Kim, additional, Streicher, Katie, additional, Tuffy, Kevin M., additional, Bond, Nicholas J., additional, Cornwell, Owen, additional, Bouquet, Jerome, additional, Cheng, Lily I., additional, Dunyak, James, additional, Huang, Yue, additional, Rosenbaum, Anton I., additional, Pilla Reddy, Venkatesh, additional, Andersen, Hanne, additional, Carnahan, Robert H., additional, Crowe, James E., additional, Kuehne, Ana I., additional, Herbert, Andrew S., additional, Dye, John M., additional, Bright, Helen, additional, Kallewaard, Nicole L., additional, Pangalos, Menelas N., additional, and Esser, Mark T., additional

Published
2022
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3. Longitudinal peripheral blood transcriptional analysis of a patient with severe Ebola virus disease

Author

Kash, John C., primary, Walters, Kathie-Anne, additional, Kindrachuk, Jason, additional, Baxter, David, additional, Scherler, Kelsey, additional, Janosko, Krisztina B., additional, Adams, Rick D., additional, Herbert, Andrew S., additional, James, Rebekah M., additional, Stonier, Spencer W., additional, Memoli, Matthew J., additional, Dye, John M., additional, Davey, Richard T., additional, Chertow, Daniel S., additional, and Taubenberger, Jeffery K., additional

Published
2017
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4. Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody

Author

Mittler, Eva, Serris, Alexandra, Esterman, Emma S., Florez, Catalina, Polanco, Laura C., O’Brien, Cecilia M., Slough, Megan M., Tynell, Janne, Gröning, Remigius, Sun, Yan, Abelson, Dafna M., Wec, Anna Z., Haslwanter, Denise, Keller, Markus, Ye, Chunyan, Bakken, Russel R., Jangra, Rohit K., Dye, John M., Ahlm, Clas, Rappazzo, C. Garrett, Ulrich, Rainer G., Zeitlin, Larry, Geoghegan, James C., Bradfute, Steven B., Sidoli, Simone, Forsell, Mattias N.E., Strandin, Tomas, Rey, Felix A., Herbert, Andrew S., Walker, Laura M., Chandran, Kartik, and Guardado-Calvo, Pablo

Abstract

Emerging rodent-borne hantaviruses cause severe diseases in humans with no approved vaccines or therapeutics. We recently isolated a monoclonal broadly neutralizing antibody (nAb) from a Puumala virus–experienced human donor. Here, we report its structure bound to its target, the Gn/Gc glycoprotein heterodimer comprising the viral fusion complex. The structure explains the broad activity of the nAb: It recognizes conserved Gc fusion loop sequences and the main chain of variable Gn sequences, thereby straddling the Gn/Gc heterodimer and locking it in its prefusion conformation. We show that the nAb’s accelerated dissociation from the divergent Andes virus Gn/Gc at endosomal acidic pH limits its potency against this highly lethal virus and correct this liability by engineering an optimized variant that sets a benchmark as a candidate pan-hantavirus therapeutic.

Published
2023
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