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Stable development of agriculture in the context of innovative transformation of productive forces and structural changes is recognized as one of the directions of the National Security Strategy of the Russian Federation. Mechanisms for stimulating technological change and increasing efficiency should be aimed at achieving sustainable production criteria. The purpose of the study is to develop conceptual aspects of managing the sustainable development of agriculture using the example of livestock industries in conditions of structural transformation and technological changes. The article examines theoretical and methodological approaches to the study of problems of sustainable development of agriculture. An analysis was carried out and an assessment was made of the dynamics of crop yields and livestock production. Significant structural shifts and technological changes in the livestock subcomplex of Russia, caused by the processes of diffusion of innovations, have been identified. The authors have developed conceptual approaches to studying the problems of sustainable agricultural development in regional agricultural systems based on effective management. The main objectives of the proposed concepts are: expansion of production volumes of agricultural products, taking into account the needs of the region and export opportunities; technical and technological modernization of agricultural organizations and achieving an innovative balance of resources; compliance with the principles of rational environmental management and achieving environmental safety. The practical value of the results lies in the possibility of forming a strategy for the sustainable development of regional agricultural systems in the conditions of structural transformation and technological changes. [ABSTRACT FROM AUTHOR]