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Your search keyword '"Zhao, Bing"' showing total 20 results
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20 results on '"Zhao, Bing"'

2. The efficiency of quantum teleportation with three-qubit entangled state in a noisy environment

Author

Chang-Yue Zhang, Zhu-Jun Zheng, Zhao-Bing Fan, and Hai-Tao Ma

Subjects
Medicine, Science
Abstract

Abstract Quantum teleportation plays a significant role in the field of quantum communication. This paper investigates quantum teleportation through a noisy environment by using GHZ state and non-standard W state as quantum channels. We analyze the efficiency of quantum teleportation by solving analytically a master equation in Lindblad form. Following the quantum teleportation protocol, we obtain the fidelity of quantum teleportation as a function of evolution time. The calculation results show that the teleportation fidelity using non-standard W is higher in comparison to GHZ state at the same evolution time. Moreover, we consider the efficiency of teleportation with weak measurements and reverse quantum measurement under amplitude damping noise. Our analysis suggests that the teleportation fidelity using non-standard W is also more robust to noise than GHZ state in the same conditions. Interestingly, we found that weak measurement and its reverse operation have no positive effect on the efficiency of quantum teleportation by using GHZ and non-standard W state in the amplitude damping noise environment. In addition, we also demonstrate the efficiency of quantum teleportation can be improved by making minor modifications to the protocol.

Published
2023
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10. Structure-Activity Relationship Studies of β-Lactam-azide Analogues as Orally Active Antitumor Agents Targeting the Tubulin Colchicine Site

Author

Bing-Kai Han, Hong-Min Liu, Sai-Yang Zhang, Ying-Chao Liu, Ruo-Han Zhao, Chuang Zhang, Jun-Wei Wang, Dong-Jun Fu, Ruo-Wang Mao, Jian Song, Yu-Qing Wang, Zhang Li, Xiao-Rui Li, Zhao Bing, Ling Fu, Yan-Bing Zhang, and Feng Li

Subjects
0301 basic medicine, Azides, Administration, Oral, Down-Regulation, Mice, Nude, lcsh:Medicine, Antineoplastic Agents, Apoptosis, Pharmacology, beta-Lactams, 01 natural sciences, Article, Inhibitory Concentration 50, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Cell Movement, Tubulin, Oral administration, In vivo, Cell Line, Tumor, Animals, Humans, Colchicine, Structure–activity relationship, lcsh:Science, IC50, Mice, Inbred BALB C, Multidisciplinary, biology, 010405 organic chemistry, lcsh:R, Cadherins, Up-Regulation, 0104 chemical sciences, 030104 developmental biology, chemistry, Cell culture, Zonula Occludens-1 Protein, biology.protein, Lactam, lcsh:Q
Abstract

We have synthesized a series of new β-lactam-azide derivatives as orally active anti-tumor agents by targeting tubulin colchicine binding site and examined their structure activity relationship (SAR). Among them, compound 28 exhibited the most potent antiproliferative activity against MGC-803 cells with an IC50 value of 0.106 μM by induction of G2/M arrest and apoptosis and inhibition of the epithelial to mesenchymal transition. 28 acted as a novel inhibitor of tubulin polymerization by its binding to the colchicine site. SAR analysis revealed that a hydrogen atom at the C-3 position of the β-lactam was required for the potent antiproliferative activity of β-lactam-azide derivatives. Oral administration of compound 28 also effectively inhibited MGC-803 xenograft tumor growth in vivo in nude mice without causing significant loss of body weight. These results suggested that compound 28 is a promising orally active anticancer agent with potential for development of further clinical applications.

Published
2017

11. Thrombopoietic stimulating activity of rhTyrRS (Y341A)

Author

Mo Wei, Zhao Bing, Yu Min, Zhan Ling, Zhou Weiran, Sun Shaoyang, Yu Jinchao, Ye Yuhao, Shi Yun, Ma Liyun, Wang Xu, and Zhang Yanling

Subjects
0301 basic medicine, Male, lcsh:Medicine, Animals, Genetically Modified, Rats, Sprague-Dawley, Mice, Megakaryocyte, Cell Movement, Tyrosine-tRNA Ligase, Neoplasms, Platelet, lcsh:Science, Zebrafish, Multidisciplinary, medicine.diagnostic_test, Recombinant Proteins, medicine.anatomical_structure, Treatment Outcome, Immunohistochemistry, Female, medicine.symptom, Megakaryocytes, Blood Platelets, Biology, Article, Flow cytometry, Thrombopoiesis, 03 medical and health sciences, medicine, Human Umbilical Vein Endothelial Cells, TRNA aminoacylation, Animals, Humans, 030102 biochemistry & molecular biology, Radiotherapy, Platelet Count, lcsh:R, biology.organism_classification, Thrombocytopenia, Rats, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Mechanism of action, Immunology, Mutation, Cancer research, lcsh:Q, Bone marrow
Abstract

Tumor radiotherapy induces hematopoietic organ damage and reduces thrombocyte counts. Thrombocytopenia is a common disease. Some studies have shown that tRNA synthetase plays not only catalytic tRNA aminoacylation roles, but also functions similarly to cytokines. Recombinant human tyrosyl-tRNA synthetase with a mutated Y341A (rhTyrRS (Y341A)) promotes megakaryocyte migrate from bone marrow to peripheral blood. It would promote megakaryocytes in the lungs adhering to vascular endothelial cells and resulting in the platelet production. The purpose of this research was to investigate the efficacy of rhTyrRS (Y341A) as a therapy for thrombocytopenia and to explore its mechanism of action. We found platelet number was effectively increased by rhTyrRS (Y341A) via platelet count and reticulated platelets (RPs) flow cytometry. We also demonstrated radiation-induced thrombocytopenia could be prevented by rhTyrRS (Y341A). The results of immunohistochemistry and H&E staining showed the number of pulmonary mature megakaryocytes was significantly increased in rhTyrRS (Y341A) treated groups. In transgenic zebrafish larvae, confocal microscopy results showed rhTyrRS (Y341A) promoted the migration and adhesion of megakaryocytes. These results suggested that rhTyrRS (Y341A) promote megakaryocytes in bone marrow migrating to lungs through blood circulation. rhTyrRS (Y341A) may be an effective medicine which could be used to treat patients suffering from thrombocytopenia.

Published
2017

12. Rivaroxaban does not influence hemorrhagic transformation in a diabetes ischemic stroke and endovascular thrombectomy model

Author

Liu, Feng-Di, primary, Zhao, Rong, additional, Feng, Xiao-Yan, additional, Shi, Yan-Hui, additional, Wu, Yi-Lan, additional, Shen, Xiao-Lei, additional, Li, Ge-Fei, additional, Liu, Yi-Sheng, additional, Zhao, Ying, additional, He, Xin-Wei, additional, Yin, Jia-Wen, additional, Zhuang, Mei-Ting, additional, Zhao, Bing-Qiao, additional, and Liu, Jian-Ren, additional

Published
2018
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14. Structure-Activity Relationship Studies of β-Lactam-azide Analogues as Orally Active Antitumor Agents Targeting the Tubulin Colchicine Site

Author

Fu, Dong-Jun, primary, Fu, Ling, additional, Liu, Ying-Chao, additional, Wang, Jun-Wei, additional, Wang, Yu-Qing, additional, Han, Bing-Kai, additional, Li, Xiao-Rui, additional, Zhang, Chuang, additional, Li, Feng, additional, Song, Jian, additional, Zhao, Bing, additional, Mao, Ruo-Wang, additional, Zhao, Ruo-Han, additional, Zhang, Sai-Yang, additional, Zhang, Li, additional, Zhang, Yan-Bing, additional, and Liu, Hong-Min, additional

Published
2017
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15. Microtubules Modulate F-actin Dynamics during Neuronal Polarization

Author

Zhao, Bing, primary, Meka, Durga Praveen, additional, Scharrenberg, Robin, additional, König, Theresa, additional, Schwanke, Birgit, additional, Kobler, Oliver, additional, Windhorst, Sabine, additional, Kreutz, Michael R., additional, Mikhaylova, Marina, additional, and Calderon de Anda, Froylan, additional

Published
2017
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