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The clinical significance of the combination of neutrophil–lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) is unclear. This study investigated the predictive value of pretreatment NLR (pre-NLR) combined with pretreatment PLR (pre-PLR) for the survival and prognosis of nasopharyngeal carcinoma (NPC). A total of 765 patients with non-metastatic NPC from two hospitals were retrospectively analyzed. The pre-NLR-PLR groups were as follows: HRG, high pre-NLR and high pre-PLR. MRG, high pre-NLR and low pre-PLR or low pre-NLR and high pre-PLR. LRG, neither high pre-NLR nor high pre-PLR. Receiver operating characteristic (ROC) curves were used to identify the cutoff-value and discriminant performance of the model. We compared survival rates and factors affecting the prognosis among different groups. The 5-year overall survival (OS), local regional recurrence-free survival (LRRFS) and distant metastasis-free survival (DMFS) of NPC patients in HRG were significantly poorer than those in MRG and LRG. The pre-NLR-PLR score was positively correlated with T stage, clinical stage, ECOG, and pathological classification. Multivariate cox regression analysis showed that pre-NLR-PLR scoring system, ECOG, pre-ALB, pre-CRP and pre-LMR were independent risk factors affecting 5-year OS, LRRFS and DMFS. The ROC curve showed that area under the curve (AUC) values of pre-NLR-PLR of 5-year OS, LRRFS and DMFS were higher than those of pre-NLR and pre-PLR. pre-NLR-PLR is an independent risk factor for the prognosis of NPC. The pre-NLR-PLR scoring system can be used as an individualized clinical assessment tool to predict the prognosis of patients with non-metastatic NPC more accurately and easily. [ABSTRACT FROM AUTHOR]

As the largest water conservancy and hydropower project in China, the Three Gorges Reservoir is a weak seismic activity area before impoundment, but the frequency of earthquakes increases significantly after impoundment. The spatial density scanning method was used to obtain the characteristics of spatio-temporal earthquake distribution in the reservoir area during loading and unloading processes. The results show that the frequencies of earthquakes during the loading and unloading processes were higher than that during the low-water-level operation period, which is well explained by the acoustic emission test results. The seismic b-value, fractal dimension D, and spatial correlation length SCL can be used together to indicate stress criticality. To analyze the impacts of reservoir water loading and unloading on seismicity in the reservoir area, time-scan analyses were performed on the b-value, D-value, and SCL of earthquakes near the Zigui segment and the Badong segment. Previous studies argued that the time-varying characteristics of b-values do not hold predictive significance for earthquakes in the M4.0–6.2 range. However, our study found that the time-varying characteristics of b-values are of predictive significance for earthquakes around M4.0. These seismic parameters decrease significantly before moderate earthquakes but at different rates in different regions. [ABSTRACT FROM AUTHOR]