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Lightweight design of leaf springs is conducive to reducing fuel consumption and improving vehicle comfort. The weight of leaf spring can be reduced obviously by using composite material. Stiffness and damping are the key factors that affect the properties of the leaf spring. The influence of the glass fiber laying angle and volume content on the stiffness and damping of the composite leaf spring was analyzed through experiment and simulation. The results show that the stiffness and damping properties of the leaf springs are related to the fiber laying angle and the fiber volume content. When the volume content and the number of layers are constant, the stiffness shows a nonlinear decreasing relationship with the laying angle, and the damping coefficient increases linearly with the laying angle. When the laying angle and the number of layers are constant, the stiffness increases linearly with the fiber volume content; the damping coefficient has a nonlinear decreasing relationship with the fiber volume content. The type of research can provide theoretical basis and reference for the design, analysis and optimization of composite leaf spring. [ABSTRACT FROM AUTHOR]

At present, the impact of cuproptosis-related genes in the study of osteosarcoma is largely unknown. Genome-wide data of osteosarcoma and controls were downloaded from 3 different databases, and specific diagnostic models associated with cuproptosis in osteosarcoma were constructed by support vector machines with artificial intelligence, random forest trees and LASSO regression. Differential analysis of immune cell infiltration was examined using routine blood data from 25,665 cases. Differential expression was examined using immunohistochemistry and PCR. PDHA1 and CDKN2A were obtained as specific cuproptosis-related biomarkers for osteosarcoma after artificial intelligence analysis. PDHA1, CDKN2A and neutrophils were differentially expressed in OS and control groups. PDHA1 and CDKN2A are significantly dysregulated in OS and are able to serve as biomarkers of OS. [ABSTRACT FROM AUTHOR]