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In recent years, the survival and development of traditional villages in China have been serious challenges. Rural tourism is regarded as an important way to solve rural problems, and the combination of rural culture and tourism has become a new power point for rural development. Therefore, it is necessary to explore the spatial distribution structure between traditional villages and rural tourism. In this paper, rural tourism was represented by the rural tourism characteristic village (RTCV), and Henan Province, China, was taken as a study area to analyze the distribution pattern and spatial correlation of rural tourism and traditional village (TV) and discuss the relationship between the spatial correlation and regional natural environment and socioeconomic factors. The results show that the coupling of the spatial correlation between RTCVs and TVs in Henan was clear. They could be divided into 5 regions based on geographical factors. In addition, the research summarized 4 typical spatial structures between TVs and RTCVs in Henan based on the regional symbiosis theory, and the spatial pattern formation mechanism of TVs and RTCVs was discussed based on three driving mechanisms. The spatial structure of the two can provide reference value for other developing countries and regions to achieve sustainable rural development. [ABSTRACT FROM AUTHOR]

Air pollution is the result of comprehensive evolution of a dynamic and complex system composed of emission sources, topography, meteorology and other environmental factors. The establishment of spatiotemporal evolution model is of great significance for the study of air pollution mechanism, trend prediction, identification of pollution sources and pollution control. In this paper, the air pollution system is described based on cellular automata and restricted agents, and a Swarm Intelligence based Air Pollution SpatioTemporal Evolution (SI-APSTE) model is constructed. Then the spatiotemporal evolution analysis method of air pollution is studied. Taking Henan Province before and after COVID-19 pandemic as an example, the NO2 products of TROPOMI and OMI were analysed based on SI-APSTE model. The tropospheric NO2 Vertical Column Densities (VCDs) distribution characteristics of spatiotemporal variation of Henan province before COVID-19 pandemic were studied. Then the tropospheric NO2 VCDs of TROPOMI was used to study the pandemic period, month-on-month and year-on-year in 18 urban areas of Henan Province. The results show that SI-APSTE model can effectively analyse the spatiotemporal evolution of air pollution by using environmental big data and swarm intelligence, and also can establish a theoretical basis for pollution source identification and trend prediction. [ABSTRACT FROM AUTHOR]

Based on the disaster-pregnant environment and development characteristics of landslide disasters in the western region of Henan Province, a generalized model was established by taking the "oblique-cut" locking rock slope in the layered rock slope as the research object. The numerical simulation method was used to analyze the deformation and failure mechanism and stability influence law of the oblique-cut locking rock slope in western Henan under rainfall conditions. The results show that the inclination angle of the weak interlayer directly affects the deformation and failure characteristics of the slope rock mass. With the increase of the geometric parameters of the slope and the inclination angle of the weak interlayer, the failure mechanism is manifested as the slip shear failure along the level at the foot of the slope → the slip shear failure along the level at the foot of the slope (the sliding surface moves upward) → the shear failure in the middle of the slope surface → the slip shear failure along the level at the foot of the slope (the sliding surface moves downward) → the uplift shear failure at the lower edge of the rock layer. When the dip angle of the weak interlayer is constant, the slope stability decreases gradually with the increase in slope gradient and slope height, and the geometric factors of the slope control the overall change trend of the slope stability coefficient. When the slope is greater than 55° and the slope height is greater than 55 m, the shear stress of the slope locking section exceeds its shear strength, and the probability of landslide instability is greatly increased. [ABSTRACT FROM AUTHOR]

The Yellow River Basin has a wealth of tourism resources, a long history of folk sports, and strong legislative support, all of which are advantages for the growth of the sports tourism sector. This study constructs an evaluation index system based on panel data from nine provinces and regions in the Yellow River Basin from 2011 to 2020, and then measures the development index and analyzes the driving factors using the entropy method, coupling coordination degree model, kernel density estimation method, and grey correlation analysis method. The findings demonstrate that (1) the Yellow River Basin's overall level of growth in the sports and tourist sectors exhibits a consistent and upward trend and that Shandong and Henan provinces clearly have an edge over other provinces in terms of development. (2) The geographical development pattern was lower Yellow River > upper Yellow River > middle Yellow River, and the coupling coordination status shifted from slight disorder to good coordination. (3) There is a close connection between sports tourism and variables including population density, financial prowess, and infrastructure growth. The employment population index has the smallest link with invention patent authorization. The macro-policy framework should therefore be strengthened in the future, the sports tourism infrastructure should be improved, and the Yellow River basin's unique sports tourism resources should be fully utilized in order to increase brand influence. In addition, new sports tourism products should be developed in response to market demand and consumer preferences, and enterprise innovation and research and development efforts should be increased in order to achieve high-quality development transformation. [ABSTRACT FROM AUTHOR]

We would like to thank the National Natural Science Foundation of China and the Young Scientists Fund for the funding for this research." We would like to thank the National Natural Science Foundation of China and the Young Scientists Fund for the funding for this research." now reads: "The authors would like to thank the Henan Adverse Drug Reaction Monitoring Center for providing the data. [Extracted from the article]

In recent years, the prevalence of allergic diseases has increased significantly, causing great concern, and wheat, as one of the top 8 food allergens, is a common allergy trigger. Nevertheless, reliable estimates of the positivity rate of wheat allergens in the allergic population in China are still lacking. The systematic review and meta-analysis aims to evaluate the positive detection rate of wheat allergens in the Chinese allergic population and further provide a reference for the prevention of allergy. CNKI, CQVIP, WAN-FANG DATA, Sino Med, PubMed, Web of Science, Cochrane Library, and Embase databases were retrieved. Related research and case reports about the positive rate of wheat allergen in the Chinese allergic population published from inception to June 30, 2022, were searched, and meta-analysis was performed using Stata software. The pooled positive rate of wheat allergens and 95% confidence interval were calculated by random effect models, and the publication bias was evaluated using Egger's test. A total of 13 articles were included for the final meta-analysis, in which wheat allergen detection methods involved only serum sIgE testing and SPT assessment. The results showed that the wheat allergen positivity detection rate in Chinese allergic patients was 7.30% (95% CI 5.68–8.92%). Subgroup analysis showed that the positivity rate of wheat allergens was influenced by region, but hardly by age and assessment method. The positive rates of wheat allergy in the population with allergic diseases were 2.74% (95% CI 0.90–4.58%) and 11.47% (95% CI 7.08–15.87%) in southern and northern China, respectively. In particular, the positive rates of wheat allergens were greater than 10% in Shaanxi, Henan and Nei Mongol, all of which belong to the northern region. These results suggest that wheat allergens are an important cause of sensitization in allergic populations from northern China, and therefore attention should be paid to early prevention in high-risk populations. [ABSTRACT FROM AUTHOR]

Industrial parks contribute greatly to China's economic development while emitting huge air pollutants. It is necessary to study the characteristics of air pollutant emissions in industrial parks. In this study, emission inventories for 11 industrial parks were established. Meanwhile, the source emission and spatial distribution characteristics of the industrial park were analyzed. The cluster analysis was used to classify these parks into "4Hs", "Mixed" and "4Ls" parks. "4Hs", "Mixed" and "4Ls" represent that the levels of energy intensity, economic proportion of energy-intensive industries, coal proportion and pollution performance value are high, medium and low in turn. Then three emission reduction measures were set up to estimate the emission reduction potential and environmental impacts. The results show that: (1) the emissions of SO2, NOx, CO, PM10, PM2.5, VOCs and NH3 of 11 industrial parks in 2017 were 11.2, 23.1, 30.8, 8.3, 3.5, 5.1, and 1.1 kt, respectively. (2) Power plants were the largest source of SO2 and NOx emissions, and industrial processes were the largest emission source of CO, PM10, PM2.5, VOCs and NH3. (3) "4Hs" parks with traditional energy-intensive industries as the leading industries should be the emphasis of air pollutant emission reduction. (4) Through the optimal emission reduction measures, SO2, NOx, PM10, PM2.5 and VOCs were reduced by 81, 46, 51, 46 and 77%, respectively. Environmental impact reductions include 1.6 kt SO2eq acidified gas emissions, 1.4 kt PO43−eq eutrophication substances, 4.2 kt PM10eq atmospheric particulate emissions, 7.0 kt 1,4-DCEeq human toxic substances, and 5.2 kt PM2.5 eq breathing Inorganic. This study is helpful to understand the characteristics of air pollutants emissions in industrial parks and promotes the proposal and implementation of air pollutant emissions reduction strategies. [ABSTRACT FROM AUTHOR]

Adverse drug reactions (ADRs) may be a serious public health problem and have received widespread attention in recent years. This study has analyzed the factors leading to the occurrence of serious ADRs (SADRs), determined the factors affecting the prognosis of patients with severe adverse reactions at different levels of medical institutions, and finally made corresponding recommendations for the monitoring, prevention, and treatment of SADRs. We used descriptive analysis and chi-square test to analyze the year, age, gender, proportion of SADRs, and the results of the ADRs in the report. Use the logistic regression to analyze the factors affecting the prognosis of SADRs in different levels of medical institutions. A total of 387 642 people's 394 037 ADRs were collected from the Henan Provincial Adverse Drug Reaction Monitoring Center from 2016 to 2020. Among them 35 742 cases of serious ADRs (9.1%), 96.1% were eventually relieved or cured, but 39 cases of SADRs caused death. The main causes of death included hemorrhages, organ failure, and allergies. Age, number of medication and illnesses, level of medical institution, history of adverse reactions, and type and method of medication were all factors that affected the severity of ADR. The prognosis of SADRs is worse than normal ADRs. The ADRs in autumn and winter and new adverse reactions are unique risk factors found in this study. The elderly and patients with multiple diseases or taking multiple drugs should pay attention to their adverse reactions. They should be closely observed within a week after taking the medicine. The supervision of patients with a history of allergies and new adverse reactions should be strengthened by primary medical institutions, and in nonprimary medical institutions should paid attention with past medical histories, and use imported drugs and biological agents with caution to ensure the safety and health of patients. [ABSTRACT FROM AUTHOR]

One RIL population derived from the cross between Dalibao and BYL8 was used to examine the phenotypes of kernel-related traits in four different environments. Six important kernel traits, kernel length (KL), kernel width (KW), kernel perimeter (KP), kernel area (KA), kernel length/width ratio (KLW), and thousand-kernel weight (TKW) were evaluated in Yangling, Shaanxi Province, China (2016 and 2017), Nanyang, Henan Province, China (2017) and Suqian, Jiangsu Province, China (2017). A genetic linkage map was constructed using 205 SSR markers, and a total of 21 significant QTLs for KL, KW, KP, KA, KLW and TKW were located on 10 of the 21 wheat chromosomes, including 1A, 1B, 2A, 2B, 2D, 3D, 4D, 5A, 5B, and 7D, with a single QTL in different environments explaining 3.495–30.130% of the phenotypic variation. There were four loci for KLW, five for KA, five for KL, three for KP, two for KW, and two for TKW among the detected QTLs. We used BSA + 660 K gene chip technology to reveal the positions of major novel QTLs for KLW. A total of 670 out of 5285 polymorphic SNPs were detected on chromosome 2A. The SNPs in 2A are most likely related to the major QTL, and there may be minor QTLs on 5B, 7A, 3A and 4B. SSR markers were developed to verify the chromosome region associated with KLW. A linkage map was constructed with 7 SSR markers, and a major effect QTL was identified within a 21.55 cM interval, corresponding to a physical interval of 10.8 Mb in the Chinese Spring RefSeq v1.0 sequence. This study can provide useful information for subsequent construction of fine mapping and marker-assisted selection breeding. [ABSTRACT FROM AUTHOR]

Hand, foot, and mouth disease (HFMD) is a common childhood illness caused by enteroviruses. HFMD outbreaks and reported cases have sharply increased in China since 2008. Epidemiological and clinical data of HFMD cases reported in Henan Province were collected from 2008 to 2013. Clinical specimens were obtained from a subset of these cases. Descriptive epidemiological methods were used to analyze the time, region and population distribution. The VP1 gene from EV71 and CA16 isolates was amplified, and the sequences were analyzed. 400,264 cases of HFMD were reported in this study, including 22,309 severe and 141 fatal cases. Incidence peaked between April and May. Laboratory confirmation was obtained for 27,692 (6.9%) cases; EV71, CA16, and other enteroviruses accounted for 59.5%, 14.1%, 26.4%, respectively. Phylogenetic analysis revealed that EV71 belonged to the C4a evolution branch of C4 sub-genotype and CA16 belonged to subtype B1a or B1b. The occurrence of HFMD in Henan was closely related to season, age and region distribution. Children under five were the most affected population. The major pathogens causing HFMD and their genotypes have not notably changed in Henan. The data strongly support the importance of EV71 vaccination in a high population density area such as Henan, China. [ABSTRACT FROM AUTHOR]