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In this study, a ZnO/MnO nanocomposite was myco-fabricated using the isolated endophytic Clonostachys rosea strain EG99 as the nano-factory. The extract of strain EG99, a reducing/capping agent, was successfully titrated with equal quantities of Zn(NO3)2·6H2O and Mn(NO3)2·6H2O (precursors) in a single step to fabricate the rod-shaped ZnO/MnO nanocomposite of size 6.22 nm. The ZnO/MnO nanocomposite was myco-fabricated in 20 min, and the results were validated at 350 and 400 nm using UV–Vis spectroscopy. In a 7-L bioreactor, an industrial biotechnological approach was used to scale up the biomass of this strain, EG99, and the yield of the myco-fabricated ZnO/MnO nanocomposite. A controlled fed-batch fermentation system with a specific nitrogen/carbon ratio and an identical feeding schedule was used in this production process. Higher yields were obtained by adopting a controlled fed-batch fermentation approach in a 7-L bioreactor with a regular feeding schedule using a nitrogen/carbon ratio of 1:200. Overall, the fed-batch produced 89.2 g/l of biomass at its maximum, 2.44 times more than the batch's 36.51 g/l output. Furthermore, the fed-batch's maximum ZnO/MnO nanocomposite yield was 79.81 g/l, a noteworthy 14.5-fold increase over the batch's yield of 5.52 g/l. Finally, we designed an innovative approach to manage the growth of the endophytic strain EG99 using a controlled fed-batch fermentation mode, supporting the rapid, cheap and eco-friendly myco-fabrication of ZnO/MnO nanocomposite. At a dose of 210 µg/ml, the tested myco-fabricated ZnO/MnO nanocomposite exhibited the maximum antibacterial activity against Staphylococcus aureus (98.31 ± 0.8%), Escherichia coli (96.70 ± 3.29%), and Candida albicans (95.72 ± 0.95%). At the same dose, Staphylococcus aureus biofilm was eradicated in 48 h; however, Escherichia coli and Candida albicans biofilms needed 72 and 96 h, respectively. Our myco-fabricated ZnO/MnO nanocomposite showed strong and highly selective antagonistic effects against a variety of multidrug-resistant human pathogens. Therefore, in upcoming generations of antibiotics, it might be employed as a nano-antibiotic. [ABSTRACT FROM AUTHOR]

In this paper, tri-phase Fe2O3–MgO–CuO nanocomposites (NCs) and pure CuO, Fe2O3 and MgO nanoparticles (NPs) were prepared using sol–gel technique. The physical properties of the prepared products were examined using SEM, XRD, and UV–visible. The XRD data indicated the formation of pure CuO, Fe2O3 and MgO NPs, as well as nanocomposite formation with Fe2O3 (cubic), MgO (cubic), and CuO (monoclinic). The crystallite size of all the prepared samples was calculated via Scherrer's formula. The energy bandgap of CuO, Fe2O3 and MgO and Fe2O3–MgO–CuO NCs were computed from UV–visible spectroscopy as following 2.13, 2.29, 5.43 and 2.96 eV, respectively. The results showed that Fe2O3–MgO–CuO NCs is an alternative material for a wide range of applications as optoelectronics devices due to their outstanding properties. [ABSTRACT FROM AUTHOR]

In this paper, tri-phase Fe2O3–MgO–CuO nanocomposites (NCs) and pure CuO, Fe2O3 and MgO nanoparticles (NPs) were prepared using sol–gel technique. The physical properties of the prepared products were examined using SEM, XRD, and UV–visible. The XRD data indicated the formation of pure CuO, Fe2O3 and MgO NPs, as well as nanocomposite formation with Fe2O3 (cubic), MgO (cubic), and CuO (monoclinic). The crystallite size of all the prepared samples was calculated via Scherrer's formula. The energy bandgap of CuO, Fe2O3 and MgO and Fe2O3–MgO–CuO NCs were computed from UV–visible spectroscopy as following 2.13, 2.29, 5.43 and 2.96 eV, respectively. The results showed that Fe2O3–MgO–CuO NCs is an alternative material for a wide range of applications as optoelectronics devices due to their outstanding properties. [ABSTRACT FROM AUTHOR]

In this manuscript, "Get two mangoes with one stone" strategy was used to study the electrochemical detection and photocatalytic mineralization of furaltadone (FLT) drug using Cu/Ni/TiO2/MWCNTs nanocomposites for the first time. The bi-functional nanocomposites were synthesized through a hydrothermal synthesis technique. The successfully synthesized nanocomposites were analyzed by various analytical techniques. The Cu/Ni/TiO2/MWCNTs nanocomposites decorated screen-printed carbon electrode (SPCE) exhibit a good electrocatalytic ability towards detection of FLT. Moreover, the electrocatalytic detection of FLT based on the nanocomposites decorated SPCE have high stability, lower detection limit, and excellent sensitivity of 0.0949 μM and 1.9288 μA μM−1 cm−2, respectively. In addition, the nanocomposites decorated SPCE electrodes performed in real samples, such as river water and tap water, the satisfactory results were observed. As UV–Visible spectroscopy revealed that the Cu/Ni/TiO2/MWCNTs nanocomposites had an excellent photocatalytic ability for degradation of FLT drug. The higher degradation efficiency of 75% was achieved within 45 min under irradiation of visible light. In addition, after the degradation process various intermediates are produced which is confirmed by GC–MS analysis. The excellent photocatalytic ability was improved to the dopant ions and restrictions of electron–hole pair. [ABSTRACT FROM AUTHOR]

In this manuscript, "Get two mangoes with one stone" strategy was used to study the electrochemical detection and photocatalytic mineralization of furaltadone (FLT) drug using Cu/Ni/TiO2/MWCNTs nanocomposites for the first time. The bi-functional nanocomposites were synthesized through a hydrothermal synthesis technique. The successfully synthesized nanocomposites were analyzed by various analytical techniques. The Cu/Ni/TiO2/MWCNTs nanocomposites decorated screen-printed carbon electrode (SPCE) exhibit a good electrocatalytic ability towards detection of FLT. Moreover, the electrocatalytic detection of FLT based on the nanocomposites decorated SPCE have high stability, lower detection limit, and excellent sensitivity of 0.0949 μM and 1.9288 μA μM−1 cm−2, respectively. In addition, the nanocomposites decorated SPCE electrodes performed in real samples, such as river water and tap water, the satisfactory results were observed. As UV–Visible spectroscopy revealed that the Cu/Ni/TiO2/MWCNTs nanocomposites had an excellent photocatalytic ability for degradation of FLT drug. The higher degradation efficiency of 75% was achieved within 45 min under irradiation of visible light. In addition, after the degradation process various intermediates are produced which is confirmed by GC–MS analysis. The excellent photocatalytic ability was improved to the dopant ions and restrictions of electron–hole pair. [ABSTRACT FROM AUTHOR]