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Your search keyword '"Meng, Lu"' showing total 2 results
2 results on '"Meng, Lu"'

1. Expression patterns and prognostic value of RUNX genes in kidney cancer.

Author

Gao, Ke, Zhang, Fang, Chen, Ke, Li, Wei, Guan, Yi-Bing, Xu, Meng-Lu, Chong, Tie, and Dai, Zhi-Ming

Subjects
GENE expression, RENAL cell carcinoma, TRANSCRIPTION factors, DNA methylation, BIOMARKERS
Abstract

Kidney cancer is the third most common malignancy of the urinary system, of which, kidney renal clear cell carcinoma (KIRC) accounts for the vast majority. Runt-related transcription factors (RUNX) are involved in multiple cellular functions. However, the diverse expression patterns and prognostic values of RUNX genes in kidney cancer remained to be elucidated. In our study, we mined the DNA methylation, transcriptional and survival data of RUNX genes in patients with different kinds of kidney cancer through Oncomine, Gene Expression Profiling Interactive Analysis, UALCAN, Kaplan–Meier Plotter, cBioPortal and LinkedOmics. We found that RUNX1 and RUNX3 were upregulated in KIRC tissues compared with those in normal tissues. The survival analysis results indicated a high transcription level of RUNX1 was associated with poor overall survival (OS) in KIRC patients. Furthermore, KIRC tumor tissues had significantly lower levels of RUNX1 promoter methylation than that in paracancerous tissues, with decreased DNA methylation of RUNX1 notably associated with poor OS in KIRC. In conclusion, our results revealed that RUNX1 may be a potential therapeutic target for treating KIRC, and RUNX1 promoter methylation level shows promise as a novel diagnostic and prognostic biomarker, which laid a foundation for further study. [ABSTRACT FROM AUTHOR]

Published
2021
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2. Serum Uric Acid Is Associated with Erectile Dysfunction: A Population-Based Cross-Sectional Study in Chinese Men

Author

Yi Chen, Zhen Cang, Chi Chen, Yingli Lu, Fangzhen Xia, Fengbin Gao, Boren Jiang, Hualing Zhai, Ningjian Wang, Meng Lu, Yingchao Chen, Qin Li, Zhoujun Shen, Ying Meng, and Bing Han

Subjects
Adult, Blood Glucose, Male, China, medicine.medical_specialty, Cross-sectional study, Science, Population, Blood Pressure, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Erectile Dysfunction, Diabetes mellitus, Internal medicine, medicine, Humans, education, Aged, Aged, 80 and over, Glycated Hemoglobin, education.field_of_study, Multidisciplinary, Free androgen index, business.industry, Middle Aged, medicine.disease, Uric Acid, Erectile dysfunction, Blood pressure, Endocrinology, chemistry, Medicine, Glycated hemoglobin, Follicle Stimulating Hormone, Luteinizing hormone, business, Biomarkers
Abstract

The role that serum uric acid (UA) plays in the pathophysiological development of erectile dysfunction (ED) is controversial. We aimed to screen the factors related with ED, and to examine the association between serum UA and ED. Our data were derived from a cross-sectional Survey on Prevalence in East China for Metabolic Diseases and Risk Factors study in 2014–2015. Questionnaire of International Index of Erectile Dysfunction-5 was used for assessment of ED. Data were collected in three general communities respectively. A total of 1365 men were enrolled with an overall mean age 55.5 ± 10.8 years (range: 20–83 years). The prevalence of ED was 62.4% (51.4% standardized) in the population. Males with ED were older, and more prone to have a higher follicle-stimulating hormone, luteinizing hormone, sex hormone-binding globulin, glycated hemoglobin, fasting plasma glucose levels and lower free androgen index (FAI), UA levels, and more likely to have diabetes and elevated blood pressure compared with those without ED. Age and UA were independent influencing factors for ED. Besides, UA was positively correlated with FAI after adjustment for age. In conclusion, our study demonstrated the protective role that UA might play in development of ED.

Published
2017

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