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In all-day-all-weather tasks, well-aligned multi-modality images pairs can provide extensive complementary information for image-guided UAV target detection. However, multi-modality images in real scenarios are often misaligned, and images registration is extremely difficult due to spatial deformation and the difficulty narrowing cross-modality discrepancy. To better overcome the obstacle, in this paper, we construct a General Cross-Modality Registration (GCMR) Framework, which explores generation registration pattern to simplify the cross-modality image registration into a easier mono-modality image registration with an Image Cross-Modality Translation Network (ICMTN) module and a Multi-level Residual Dense Registration Network (MRDRN). Specifically, ICMTN module is used to generate a pseudo infrared image taking a visible image as input and correct the distortion of structural information during the translation of image modalities. Benefiting from the favorable geometry correct ability of the ICMTN, we further employs MRDRN module which can fully extract and exploit the mutual information of misaligned images to better registered Visible and Infrared image in a mono-modality setting. We evaluate five variants of our approach on the public Anti-UAV datasets. The extensive experimental results demonstrate that the proposed architecture achieves state-of-the-art performance. [ABSTRACT FROM AUTHOR]