1. Serum branched-chain amino acids are associated with leukocyte telomere length and frailty based on residents from Guangxi longevity county.
- Author
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Zhang, Ying, Zhou, Qi, Yang, Ruiyue, Hu, Caiyou, Huang, Zezhi, Zheng, Chenguang, Liang, Qinghua, Gong, Ranhui, Zhu, Xiaoquan, Gong, Huan, Yuan, Huiping, Chen, Chen, Li, Xianghui, Zhang, Nan, Yang, Ze, and Sun, Liang
- Subjects
AMINO acids ,TELOMERES ,BLOOD serum analysis ,LIQUID chromatography - Abstract
Branched-chain amino acids (BCAAs) and telomere length are biologically associated with healthy aging. However, the association between them and their interaction on frailty remain unclear in humans. Here, a cross-sectional study based on residents from Guangxi longevity county was conducted to investigate the association of serum BCAAs, peripheral leukocyte telomere length (LTL) and frailty. A total of 1,034 subjects aged 20 to 110 years were recruited in the study. The real-time qPCR method and a targeted metabolomics approach based on isotope dilution liquid chromatography tandem mass spectrometry (LC/MS/MS) method were used for measurement of LTL and BCAAs, respectively. A frailty score defined as the proportion of accumulated deficits based on 24 aging-related items was used assess the health status of elderly subjects. First, we found that a higher concentration of BCAAs was significantly associated with longer LTL only in middle-aged subjects, independent of age and BMI (P < 0.05). In the oldest-old subjects, we identified a significantly inverse association between BCAAs and frailty score (P < 0.001), even after adjustment for age and BMI (P < 0.05). Additionally, we recognized a statistically significant synergetic interaction between BCAAs and LTL on frailty score in the oldest-old subjects by the general linear model (P = 0.042), although we did not find any significant association between LTL and frailty score. In summary, our findings suggest a potentially protective effect of circulating BCAAs on LTL and frailty based on the subjects from longevity county in East Asia and indicate a potential synergetic interaction between BCAAs and LTL in healthy aging. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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