1. CCAAT/enhancer-binding protein α is required for hepatic outgrowth via the p53 pathway in zebrafish.
- Author
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Yuan, Hao, Wen, Bin, Liu, Xiaohui, Gao, Ce, Yang, Ruimeng, Wang, Luxiang, Chen, Saijuan, Chen, Zhu, de The, Hugues, Zhou, Jun, and Zhu, Jun
- Subjects
PROTEIN binding ,P53 protein ,ZEBRA danio ,ADIPOGENESIS ,HEMATOPOIESIS ,NEONATAL death - Abstract
CCAAT/enhancer-binding protein α (C/ebpα) is a transcription factor that plays important roles in the regulation of hepatogenesis, adipogenesis and hematopoiesis. Disruption of the C/EBPα gene in mice leads to disturbed liver architecture and neonatal death due to hypoglycemia. However, the precise stages of liver development affected by C/ebpα loss are poorly studied. Using the zebrafish embryo as a model organism, we show that inactivation of the cebpa gene by TALENs results in a small liver phenotype. Further studies reveal that C/ebpα is distinctively required for hepatic outgrowth but not for hepatoblast specification. Lack of C/ebpα leads to enhanced hepatic cell proliferation and subsequent increased cell apoptosis. Additional loss of p53 can largely rescue the hepatic defect in cebpa mutants, suggesting that C/ebpα plays a role in liver growth regulation via the p53 pathway. Thus, our findings for the first time demonstrate a stage-specific role for C/ebpα during liver organogenesis. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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