Search

This study aimed to investigate innovative targets in breast cancer patients by considering the interaction of the lncRNA-miR-mRNA network in response to low-dose aspirin. The candidate miRs were first taken from the GEO and TCGA databases. Then, the candidate network was constructed using the high-throughput sequencing data. The expression levels of candidate targets were finally measured using Real-Time PCR in luminal A breast cancer patients undergoing aspirin (80 mg daily for three months) and non-aspirin groups during chemotherapy after surgery. The expression levels of TGFβ, IL-17, IFNγ, and IL-β proteins were measured using the ELISA technique. 5 lncRNAs, 12 miRs, and 10 genes were obtained in the bioinformatic phase. A significant expression increase of the candidate tumor suppressor lncRNAs, miRs, and genes and a substantial expression decrease of the candidate onco-lncRNAs, oncomiRs, and oncogenes were achieved after the aspirin consumption. Unlike the non-aspirin group, the expression levels of TGFβ, IL-17, IFNγ, and IL-β proteins were significantly decreased following aspirin consumption. The Kaplan–Meier analysis indicated a longer overall survival rate in the patients after aspirin consumption. Our results showed that the lncRNA-miR-mRNA network might be a significant target for aspirin; their expression changes may be a new strategy with potential efficacy for cancer therapy or prevention. [ABSTRACT FROM AUTHOR]

This document is a retraction note from the journal Scientific Reports regarding an article titled "The toxicity and therapeutic effects of single-and multi-wall carbon nanotubes on mice breast cancer." The editors have retracted the article due to the discovery that several panels in Figure 10 were identical to panels in Figure 1 of another article that was simultaneously under consideration at a different journal. Additionally, it was found that the error bars in all figures were incorrectly labeled as standard deviation instead of ± 5%. The editors no longer have confidence in the results and conclusions of the article. One author disagrees with the retraction, another author has not stated their agreement, and the publisher has been unable to contact another author. [Extracted from the article]