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After completing treatment for head and neck cancer (HNC), patients often face oral complications like oral pain, limited mouth opening and dry mouth which significantly reduce their oral health related quality of life (OHRQoL). These issues impact their overall well-being, social activities and long-term survival. The primary objective of this study was to evaluate OHRQoL and its association with sociodemographic characteristics, oral hygiene practices and oral clinical parameters such as oral hygiene status and oral mucositis grade in patients who have completed treatment for head and neck cancer. This cross-sectional study involved 79 HNC-treated patients within first year after completion of cancer treatment attending ENT and dental clinics at outpatient department (OPD) setting in Karachi. Data was collected electronically using structured questionnaire comprising of EORTC QLQ H&N - 35 to measure OHRQoL, patients were also examined for oral hygiene status using oral hygiene index- simplified (OHI-s) and oral mucositis grade using WHO oral mucositis scale. Multiple linear regression was used to test OHRQoL associations with the sociodemographic and different clinical factors. The result showed an overall mean score for oral health related quality of life (OHRQoL) of 25.02 ± 15.86 (95% CI 21.46-28.57), with difficulty in mouth opening 53.16 ± 18.88 and dry mouth 45.14 ± 24.48 being predominant concerns for decline in the OHRQoL in the population. Male predilection was observed among participants n = 60 (75.9%), majority of the participants n = 41 (51.9%) were below 52 years of age. n = 63 (80%) participants received radiotherapy alongside surgery and chemotherapy. Most of participants n = 66 (83.5%) experienced moderate to severe oral mucositis with poor oral hygiene status n = 56 (71%). Significant associations were found between OHRQoL and BMI, OH status, marital status, monthly income, gender and fluoride toothpaste (p < 0.05). These findings suggest that Quality of Life (QoL) among HNC treated patients is negatively impacted by their poor oral health, post cancer treatment. Therefore, it is important to evaluate and modify the current treatment modalities and involve multidisciplinary teams, to improve their OHRQoL thereby enhancing overall QoL., (© 2024. The Author(s).)

We show that the most generic form of spin-singlet superconducting order parameter for chiral fermions in systems with broken time reversal symmetry and inversion symmetry is of the [Formula: see text] where [Formula: see text] is the usual order parameter and [Formula: see text] is the pseudo-scalar order parameter. After factoring out the U(1) phase [Formula: see text], this form of superconductivity admits yet additional complex structure in the plane of [Formula: see text]. The polar angle [Formula: see text] in this plane, which we call the chiral angle, can be controlled by the external flux bias. We present a synthetic setup based on stacking of topological insulators (TIs) and superconductors (SCs). Alternatively flux biasing the superconductors with a fluxes [Formula: see text] leads to [Formula: see text], where [Formula: see text] is the superconducting order parameter of the SC layers, and the chiral angle [Formula: see text] is directly given by the flux [Formula: see text] in units of the flux quantum [Formula: see text]. This can be used as a building block to construct a two-dimensional Josephson array. In this setup [Formula: see text] will be a background field defining a pseudoscalar [Formula: see text] that can be tuned to desired configuration. While in a uniform background field [Formula: see text] the dynamics of [Formula: see text] is given by standard XY model and its associated vortices, a staggered background [Formula: see text] (or equivalently [Formula: see text] and [Formula: see text] in alternating lattice sites) creates a new set of minima for the [Formula: see text] field that will support half-vortex excitations. An isolated single engineered "half-vortex" in the [Formula: see text] field in an otherwise uniform background will bind a [Formula: see text]-half-vortex. This is similar to the way a p-wave superconducting vortex core binds a Majorana fermion., (© 2023. Springer Nature Limited.)

Prospective customers are becoming more concerned about safety and comfort as the automobile industry swings toward automated vehicles (AVs). A comprehensive evaluation of recent AVs collision data indicates that modern automated driving systems are prone to rear-end collisions, usually leading to multiple-vehicle collisions. Moreover, most investigations into severe traffic conditions are confined to single-vehicle collisions. This work reviewed diverse techniques of existing literature to provide planning procedures for multiple vehicle cooperation and collision avoidance (MVCCA) strategies in AVs while also considering their performance and social impact viewpoints. Firstly, we investigate and tabulate the existing MVCCA techniques associated with single-vehicle collision avoidance perspectives. Then, current achievements are extensively evaluated, challenges and flows are identified, and remedies are intelligently formed to exploit a taxonomy. This paper also aims to give readers an AI-enabled conceptual framework and a decision-making model with a concrete structure of the training network settings to bridge the gaps between current investigations. These findings are intended to shed insight into the benefits of the greater efficiency of AVs set-up for academics and policymakers. Lastly, the open research issues discussed in this survey will pave the way for the actual implementation of driverless automated traffic systems., (© 2023. The Author(s).)

One of the major challenges in bone grafting is the lack of sufficient bone vascularization. A rapid and stable bone vascularization at an early stage of implantation is essential for optimal functioning of the bone graft. To address this, the ability of in situ TiO2 nanofibrous surfaces fabricated via thermal oxidation method to enhance the angiogenic potential of human umbilical vein endothelial cells (HUVECs) was investigated. The cellular responses of HUVECs on TiO2 nanofibrous surfaces were studied through cell adhesion, cell proliferation, capillary-like tube formation, growth factors secretion (VEGF and BFGF), and angiogenic-endogenic-associated gene (VEGF, VEGFR2, BFGF, PGF, HGF, Ang-1, VWF, PECAM-1 and ENOS) expression analysis after 2 weeks of cell seeding. Our results show that TiO2 nanofibrous surfaces significantly enhanced adhesion, proliferation, formation of capillary-like tube networks and growth factors secretion of HUVECs, as well as leading to higher expression level of all angiogenic-endogenic-associated genes, in comparison to unmodified control surfaces. These beneficial effects suggest the potential use of such surface nanostructures to be utilized as an advantageous interface for bone grafts as they can promote angiogenesis, which improves bone vascularization.