1. Spatiotemporal clustering of cases of Kawasaki disease and associated coronary artery aneurysms in Canada
- Author
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Bailey Bernknopf, Brigitte Mueller, Jason Hearn, Sunita O’Shea, Cedric Manlhiot, Brian W. McCrindle, and Michael Labelle
- Subjects
Male ,medicine.medical_specialty ,Canada ,Adolescent ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Mucocutaneous Lymph Node Syndrome ,Article ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Spatio-Temporal Analysis ,Risk Factors ,Internal medicine ,medicine ,Cluster Analysis ,Humans ,030212 general & internal medicine ,lcsh:Science ,Child ,Coronary artery aneurysm ,Multidisciplinary ,business.industry ,Incidence (epidemiology) ,Incidence ,lcsh:R ,Coronary Aneurysm ,medicine.disease ,medicine.anatomical_structure ,Relative risk ,Child, Preschool ,Etiology ,Kawasaki disease ,lcsh:Q ,Female ,business ,Spatio temporal clustering ,Artery - Abstract
Detailed epidemiologic examination of the distribution of Kawasaki disease (KD) cases could help elucidate the etiology and pathogenesis of this puzzling condition. Location of residence at KD admission was obtained for patients diagnosed in Canada (excluding Quebec) between March 2004 and March 2015. We identified 4,839 patients, 164 of whom (3.4%) developed a coronary artery aneurysm (CAA). A spatiotemporal clustering analysis was performed to determine whether non-random clusters emerged in the distributions of KD and CAA cases. A high-incidence KD cluster occurred in Toronto, ON, between October 2004 and May 2005 (116 cases; relative risk (RR) = 3.43; p
- Published
- 2018