1. Diffuse microglial responses and persistent EEG changes correlate with poor neurological outcome in a model of subarachnoid hemorrhage
- Author
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Joseph R. Geraghty, Mitchell Butler, Biswajit Maharathi, Alexander J. Tate, Tyler J. Lung, Giri Balasubramanian, Fernando D. Testai, and Jeffrey A. Loeb
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Subarachnoid hemorrhage ,Electroencephalography ,Spectral analysis ,Inflammation ,Microglia ,Fingolimod ,Medicine ,Science - Abstract
Abstract The mechanism by which subarachnoid hemorrhage (SAH) leads to chronic neurologic deficits is unclear. One possibility is that blood activates microglia to drive inflammation that leads to synaptic loss and impaired brain function. Using the endovascular perforation model of SAH in rats, we investigated short-term effects on microglia together with long-term effects on EEG and neurologic function for up to 3 months. Within the first week, microglia were increased both at the site of injury and diffusely across the cortex (2.5-fold increase in SAH compared to controls, p = 0.012). Concomitantly, EEGs from SAH animals showed focal increases in slow wave activity and diffuse reduction in fast activity. When expressed as a fast-slow spectral ratio, there were significant interactions between group and time (p
- Published
- 2024
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