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We present the Manatee variational autoencoder model to predict transcription factor (TF) perturbation-induced transcriptomes. We demonstrate that the Manatee in silico perturbation analysis recapitulates target transcriptomic phenotypes in diverse cellular lineage transitions. We further propose the Manatee in silico screening analysis for prioritizing TF combinations targeting desired transcriptomic phenotypes.

This paper studies the consensus problem for a class of unknown heterogeneous nonlinear multi-agent systems via a network with random packet dropouts. Based on the dynamic linearization technique, novel model-free adaptive consensus protocols with the data compensation mechanism are designed for both leaderless and leader-following cases. The advantage of this approach is that only neighborhood input and output data of the agents are required in the protocol design. For the stability analysis, a new Squeeze Theorem based method is developed to derive the theoretic results instead of the traditional contraction mapping principle used in model-free adaptive control. It is shown that the consensus can be achieved for both leaderless and leader-following cases if the communication topology is strongly connected. Finally, numerical simulations verifying the correctness of the theoretical results are given. [ABSTRACT FROM AUTHOR]

Antibody escape mutations pose a significant challenge to the effectiveness of vaccines and antibody-based therapies. The ability to predict these escape mutations with computer simulations would allow us to detect threats early and develop effective countermeasures, but a lack of large-scale experimental data has hampered the validation of these calculations. In this study, we evaluate the ability of the MD+FoldX molecular modeling method to predict escape mutations by leveraging a large deep mutational scanning dataset, focusing on the SARS-CoV-2 receptor binding domain. Our results show a positive correlation between predicted and experimental data, indicating that mutations with reduced predicted binding affinity correlate moderately with higher experimental escape fractions. We also demonstrate that higher precision can be achieved using affinity cutoffs tailored to distinct SARS-CoV-2 antibodies from four different classes rather than a one-size-fits-all approach. Further, we suggest that the quartile values of optimized cutoffs reported for each class in this study can serve as a valuable guide for future work on escape mutation predictions. We find that 70% of the systems surpass the 50% precision mark, and demonstrate success in identifying mutations present in significant variants of concern and variants of interest. Despite promising results for some systems, our study highlights the challenges in comparing predicted and experimental values. It also emphasizes the need for new binding affinity methods with improved accuracy that are fast enough to estimate hundreds to thousands of antibody-antigen binding affinities. [ABSTRACT FROM AUTHOR]

The effect of bolt support in mining roadways with fractured or weak surrounding rock is poor, and the roof easily loses stability. Studying the support control technology of bolts on fractured surrounding rock is necessary. Based on the theories of pressure arches and combined arch support, the bolt anchorage and anchorage effect angle are proposed a model is established, and the optimal bolt anchorage is calculated. The influence of related factors on the bolt anchorage and the scope of bolt action are analysed via numerical simulation and experimental methods. The pretightening force of the bolts and the spacing between the rows of bolts are positively correlated and negatively correlated with the bolt anchorage, respectively. The compression zone conforms to the reinforced arch state when the bolt end is anchored. The experimental work shows that the maximum spacing a of the anchor rods and the length L of the anchor rods in the surrounding rock satisfy 4.28a < 2L < 5a. The support of fractured surrounding rock is discussed, and the concept of roof fall prevention and control with an increasing or constant pretightening force, high surface strength and reasonable support density as the core principles is proposed. A field test of the Youzhong Coal Mine shows that the corresponding support effect is good and that this work provides a new method for roof support of fractured surrounding rock. [ABSTRACT FROM AUTHOR]

The blockage and the deformation and failure of the ore pass walls constitute two major problems in applying the ore passes in mines. These problems, which affect the normal operation of mine production, have attracted widespread attention worldwide. The labeled-particle layers method based on numerical simulation was used to investigate the flow characteristics of the ore-rock bulk in the ore pass under different eccentric distances of the ore-drawing port center and ore pass centerline. Moreover, the overpressure coefficient and overpressure number are used to evaluate the degree of damage to the ore-pass wall. The results show that: (1) During the ore drawing process under different eccentricities, the flow patterns of the topmost labeled-particle layers in the ore pass are always in a "—" shaped distribution, and the other layers in the ore pass gradually transition from a "—" shape to a "U" shaped distribution, and then gradually to a "V" shape closer to the drawing funnel; (2) in the range of the ore-drawing funnel, the flow pattern of the ore-rock bulk gradually changes from an upright "V" shape to an italic "V" shape with increasing eccentricity and tip slants to the drawing port, and is less affected in the shaft; and (3) the dynamic lateral pressure caused by the ore-rock flow mainly acts on the lower part of the storage section. When the eccentricity is 0.5 m, the maximum overpressure coefficient and overpressure times are the smallest, leading to the lowest damage degree of the ore pass wall. [ABSTRACT FROM AUTHOR]

In view of the cracking, sag, and damage of sheath caused by the load effect and external force impact of power cable, the echo parameters of cable sheath damage detection based on the characteristics of torsional guided wave propagation are studied in this work. According to the Navier displacement equilibrium equation, the dispersion curve of a magnetostrictive guided wave of the cable sheath was solved, and the T(0,1) mode with a group velocity of 1198.8 m/s and no dispersion was selected. Furthermore, while considering the excitation frequency, loss rate, and direction of the damaged section, the displacement field and the echo characteristic parameters of guided wave in the cable sheath were solved. Moreover, by analyzing the time-domain signals of damaged section echo, the cubic fitting function for the loss rate of the damaged section and the damaged section echo coefficient were obtained, which can effectively characterize the quantitative relationship between the damaged location, size, and guided wave echo of the cable sheath. [ABSTRACT FROM AUTHOR]

Nonthrombotic iliac vein lesions (NIVLs) are significant causes of chronic venous insufficiency (CVI) in the left lower limb and symptom recurrence following left lower limb varicose vein treatment. The goal of this study was to explore the haemodynamic and morphological characteristics of iliac veins in patients with NIVLs. Pressure at the caudal end of the stenotic left common iliac vein (LCIV) segment, local blood flow velocity, and time-averaged wall shear stress in the stenotic segment exhibited positive correlations with the clinical CVI classification (R = 0.92, p < 0.001; R = 0.94, p < 0.001; R = 0.87, p < 0.001), while the relative retention time showed a negative correlation (R = -0.94, p < 0.001). The pressure difference (∆P) between the two ends of the stenotic segment and the velocity difference (∆V) between the stenotic segment and the caudal end were positively correlated with the clinical classification (R = 0.92, p < 0.001; R = 0.9, p < 0.001). The cross-sectional area stenosis rate and length of the stenotic LCIV segment were positively correlated with the clinical classification (R = 0.93, p < 0.001; R = 0.63, p < 0.001). The results suggest that haemodynamic assessment of the iliac vein could effectively portray blood flow disturbances in stenotic segments of the LCIV, potentially reflecting the degree of iliac vein stenosis. Haemodynamic indicators are correlated with the severity of clinical CVI symptoms. [ABSTRACT FROM AUTHOR]

Insect biodiversity and abundance are in global decline, potentially leading to a crisis with profound ecological and economic consequences. Methods and technologies to monitor insect species to aid in preservation efforts are rapidly being developed yet their adoption has been slow and focused on specific use cases. We propose a computer vision model that works towards multi-objective insect species identification in real-time and on a large scale. We leverage an image data source with 16 million instances and a recent improvement in the YOLO computer vision architecture to present a quick and open-access method to develop visual AI models to monitor insect species across climatic regions. [ABSTRACT FROM AUTHOR]

Highly efficient Metamaterials are necessary for applications in sensing, communication, etc. Fano resonance and electromagnetically induced transparency-like phenomena are essential for obtaining high Q-factor and sensitive Metamaterials. Employing both numerical simulations and experimental analysis, we investigate the emergence of Fano resonance in cross-resonator Metamaterials facilitated by the conductive coupling between dark and bright resonators. We analyze the gradual shift of the fano resonance by tuning the dark resonator and finally form an electromagnetically induced transparency-like transmission peak. The strong coupling of the resonator is observed in the form of an anti-crossing and discussed through analytical models. We demonstrate that the coupling strength of the dark and bright resonance in our metamaterial is proportional to the asymmetry parameter, albeit at the cost of the Fano resonance's Q-factor. The findings and methods introduced in this study can be used to develop highly efficient THz Metamaterials for various applications operable in room conditions. [ABSTRACT FROM AUTHOR]

This study aims to address the issue of high energy consumption in the hydrocyclone separation process. By introducing a novel slotted overflow pipe structure and utilizing experimental and response surface optimization methods, the optimal parameters were determined. The research results indicate that the number of slots, slot angles, and positioning dimensions significantly influence the performance of the hydrocyclone separator. The optimal combination was found to be three layers of slots, a positioning dimension of 5.3 mm, and a slot angle of 58°. In a Φ100mm hydrocyclone separator, validated through multiple experiments, the separation efficiency increased by 0.26% and the pressure drop reduced by 24.88% under a flow rate of 900 ml/s. CFD simulation verified the reduction in internal flow field velocity and pressure drop due to the slotted structure. Therefore, this study provides an effective reference for designing efficient and low-energy hydrocyclone separators. [ABSTRACT FROM AUTHOR]

To solve the supporting problem of high-stress red shale roadway in Kaiyang phosphate mining area, the mechanical properties and microstructure of red shale are studied. The results show that the compressive strength of the red shale is related to the bedding angle, and the strength of the 0° samples is the highest, and the strength of the 60° and 30° samples decreases gradually. With comprehensive consideration, the composite supporting method of cantilever piles and grid arch is adopted. Combining the numerical simulation and theoretical calculation, the parameters of cantilever pile with interval distance of 5 m and rock-socketed depth of 500 m are more reasonable. The monitoring results show that the roof subsidence was controlled within 250 mm, and the floor heave was within 100 mm, which could effectively control the severe deformation of the roadway and also is of great significance to the safe mining of phosphate resources. [ABSTRACT FROM AUTHOR]

In order to enhance the stability of the tilt transition process, a new configuration of Quad-Tiltrotor UAV was presented in this paper. Firstly, numerical simulation was used to calculate and analyze the aerodynamic interaction between the front rotor/fuselage/rear rotor during the transition state mode. The calculation model of the isolated rotor, front-rear rotor, front rotor-fuselage, and front rotor-rear rotor-fuselage combination states are established. Besides, the effects of pitch, roll, and yaw moment on the fuselage at different tilt angles are analyzed. It is concluded that the front rotor is the leading factor in the aerodynamic interference of the whole UAV in the different combination states. The research results can provide a reference for the optimization design of the overall layout, structure, and flight control strategy of the cross-shaped quad-tiltrotor UAV, and can also provide solutions for the logistics application of urban air traffic. [ABSTRACT FROM AUTHOR]

Abstract Nonthrombotic iliac vein lesions (NIVLs) are significant causes of chronic venous insufficiency (CVI) in the left lower limb and symptom recurrence following left lower limb varicose vein treatment. The goal of this study was to explore the haemodynamic and morphological characteristics of iliac veins in patients with NIVLs. Pressure at the caudal end of the stenotic left common iliac vein (LCIV) segment, local blood flow velocity, and time-averaged wall shear stress in the stenotic segment exhibited positive correlations with the clinical CVI classification (R = 0.92, p

To investigate the stability of a super-large section chamber group, an analysis was conducted based on the in-situ geological conditions of a super-large section chamber group utilized as a coal gangue separation system at the Longgu Coal Mine. Field measurement and numerical simulation were employed to analyze the failure area and stress state of the surrounding rock under varying chamber spacings. The results indicate that the extent of the plastic zone significantly expands when the spacing between chambers is less than 2.0 times the chamber width. When the distance between chambers is 1.5 times the chamber width, it results in the rock pillars being entirely within the plastic zone. As the chamber spacing decreases, the tangential stress within the rock pillar range increases. When the chamber spacing is 2.5, 2.0, and 1.5 times the chamber width, the maximum tangential stress is 1.19, 1.46, and 1.18 times that in the case of a single chamber, respectively. Based on the displacement analysis, it was observed that as the distance between the chambers decreases, there is a notable increase in the displacement of the pillar sides and chamber top, indicating a higher risk of collapse. Integrating the plastic area and stress analysis allows for the categorization of the rock pillar area into four sections: the broken area, loose area, stable area, and firm area. Drawing upon the theoretical solution of the plastic zone of a circular chamber and the equivalent radius method, an approximate solution for the plastic zone of a non-circular chamber has been provided. Furthermore, the minimum reasonable spacing between chambers in a super-large section chamber group is provided as a distance criterion for the failure of a double chamber. [ABSTRACT FROM AUTHOR]

Explosively formed projectile (EFP) has the advantages of high flight speed, high burst height, insensitivity to initial velocity, etc. To study the forming performance of multiple explosively formed projectile (MEFP) and to analyze the factors influencing the forming results. A directional pentagonal prism MEFP with five liners is proposed in this paper. Experiments were conducted to validate the performance of this MEFP. The experimental results show that the generated EFPs have high flight speeds. However, the EFP hit position on the target plate was offset, causing multiple positional penetrations. To analyze the causes of the phenomenon, a numerical simulation model of directional MEFP is established and the forming process of MEFP is numerically simulated. The simulation results indicate that the EFP fracture occurs during the forming process due to the asymmetric detonation wave, and its tail cannot be fully closed. Combined with the numerical simulation and experimental results, the forming performance of the liners used in the MEFP has been further developed. Further analysis was carried out on the effect of liner thickness and height on forming performance. It can be seen that as the thickness of the liners increases, the length of the head of EFP increase, the incidence of EFP tail fracture decreased, the aspect ratio increases and the EFP velocity decrease. As the height of the MEFP increases, the velocity of the EFP increases, the head ratio increases, the shape of the detonation wave tends to be symmetrical, and the tendency of the EFP to appear as an unclosed tail decreases. [ABSTRACT FROM AUTHOR]

With the shift of coal seam mining to the deep, the in-situ stress of coal and rock mass increases gradually. High ground stress can limit the generation of rock cracks caused by blasting, and blasting usually shows different crushing states than low stress conditions. In order to study the blasting expansion rule of rock mass with cavity under high ground stress and the rock mass fracture state under different side stress coefficients. In this paper, the effective range of blasting and the stress distribution under blasting load are analyzed theoretically. The RHT (Riedel-Hiermaier-Thoma) model is used to numerically simulate the blasting process of rock mass with cavity under different ground stress, and the influence of ground stress and lateral pressure coefficient on the crack growth of rock mass is studied. The results show that when there is no ground stress, the damage cracks in rock mass are more concentrated in the horizontal direction and the fracture development tends to the direction where the holes are located, which confirms the guiding effect and stress concentration effect of the holes in rock mass, which helps to promote the crack penetration between the hole and the hole. The length difference of horizontal and vertical damage cracks in rock mass increases with the increase of horizontal and vertical stress difference. Under the same lateral stress coefficient, the larger the horizontal and vertical stress difference is, the stronger the inhibition effect on crack formation is. For blasting of rock mass with high ground stress, the crack formation length between gun holes decreases with the increase of stress level, and the crack extends preferentially in the direction of higher stress. Therefore, the placement of gun holes along the direction of greater stress and the shortening of hole spacing are conducive to the penetration of cracks between gun holes and empty holes. The research can provide reference for rock breaking behavior of deep rock mass blasting. [ABSTRACT FROM AUTHOR]

Correlated states of light, both classical and quantum, can find useful applications in the implementation of several imaging techniques. Among the employed sources, pseudo-thermal states, generated by the passage of a laser beam through a diffuser, represent the standard choice. To produce light with a higher level of correlation, in this work we consider and characterize the speckled-speckle field obtained with two diffusers using both a numerical simulation and an experimental implementation. In order to discuss the potential usefulness of super-thermal light in imaging protocols, we analyze the behavior of some figures of merit, namely the contrast, the signal-to-noise ratio and the image resolution. The obtained results clarify the possible advantages offered by this kind of light, and at the same time better emphasize the reasons why it does not outperform pseudo-thermal light. [ABSTRACT FROM AUTHOR]

This paper is based on the proximity engineering project of the Baishiyi tunnel group passing under the Chongqing West Station track group. Considering the train load and the spatial relationship of the tunnel and track groups, the settlement patterns, horizontal displacement, and differential settlement of the tunnel–strata–tracks system during the excavation process are studied through theoretical calculations and numerical simulation methods. The results indicate that the tunnel vault, strata, and track settlement deformation patterns are similar. Throughout the tunnel construction process, the tracks underwent uplift, settlement, and eventually stabilized. The settlement trough formed by the excavation of the three tunnels below the track group has an impact range of 25–145 m. Between 35 and 75 m, the differential settlement of the double track gradually increases with excavation. As the tunnel face reaches 75 m, the track differential settlement gradually converges and tends to stabilize. To minimize the impact of underpass tunnel construction on track groups, it is recommended to use a combination of full-section hole grouting and surface reinforcement grouting for ground reinforcement. Additionally, optimizing the construction parameters, including the step length and primary support closure time, and strengthening the locking anchor can further reduce the impact. [ABSTRACT FROM AUTHOR]

The combustion of hydrogen and carbon-monoxide mixtures, so-called syngas, plays an increasingly important role in the safety context of non-fossil energy generation, more specifically in the risk management of incidents in process engineering plants for ammonia synthesis and in nuclear power plants. In order to characterize and simulate syngas/air combustion on industrially relevant scales, subgrid modelling is required, which is often based on a reaction progress variable. To understand the influence of different fuel compositions, turbulence intensities and flame topologies on different possible definitions of reaction progress variable, detailed chemistry direct numerical simulations data of premixed, lean hydrogen/air and syngas/air flames has been considered. A reaction progress variable based on normalized molecular oxygen mass fraction has been found not to capture the augmentation of the normalized burning rate per unit flame surface area in comparison to the corresponding 1D unstretched premixed flame due to preferential diffusion effects. By contrast, reaction progress variables based on other individual species, such as hydrogen, can capture the augmentation of the rate of burning well, but exhibit a pronounced sensitivity to preferential diffusion effects, especially in response to flame curvatures. However, a reaction progress variable based on the linear combination of the main products can accurately represent the temperature evolution of the flame for different mixtures, turbulence intensities and varying local flame topology, while effectively capturing the augmentation of burning rate due to preferential diffusion effects. However, its tendency to assume values larger than 1.0 in the regions of super-adiabatic temperatures poses challenges for future modeling approaches, whereas the reaction progress variable based on hydrogen mass fraction remains bound between 0.0 and 1.0 despite showing deviations in comparison to corresponding variations obtained from the unstretched laminar flame depending on flame curvature variations. [ABSTRACT FROM AUTHOR]

To address the measurement accuracy challenges posed by the internal flow complexity in atypical circular bend pipes with short turning sections and without extended straight pipe segments, this study designed an experimental circular "S"-shaped bent pipe with a diameter of 0.4 m and a bending angle of 135°. Numerical analysis was used to determine the stable region for velocity distribution within the experimental segment. Furthermore, a novel evaluation method based on the coefficient of variation was proposed to accurately locate the optimal position for installing thermal mass flow meters on the test cross section. Additionally, a formula for calculating the pipeline flow rate based on velocity differences was derived. This formula considers pipeline flow as the dependent variable and uses the velocity at two points in the test cross section as the independent variable. Experimental validation on a primary standard test bench demonstrated that the flow rate calculated by this method had an error controlled within 0.625% compared to the standard flow rate, thus effectively verifying the method's high accuracy and engineering applicability. This research provides a new testing methodology and practical basis for flow measurement in complex pipeline systems, offering significant guidance for research and applications in related fields. [ABSTRACT FROM AUTHOR]

Characteristic of ground pressure in surrounding rock is generally considered as the theoretical basis of parameter optimization for stope structure and technology. To explore the feasibility of efficient method for the second-step downward route backfill stopes in Shanjin gold mine, various numerical simulation methods were used to investigate the effect of slab-wall backfill structure on stability of surrounding rock in downward route mining system. The maximum principal stress, artificial false roof stress, and displacement were analyzed to evaluate the level of ground pressure in different mining areas. These results indicate the optimized structural parameters for backfill stopes, which may also provide a low-cost way to achieve a high safety for downward route mining system. [ABSTRACT FROM AUTHOR]

Non-coplanar and discontinuously jointed rock masses are more complex than coplanar and discontinuously jointed rock masses. The mechanical properties and propagation mechanisms of non-coplanar and discontinuous joints were studied via direct shear tests with microscopic numerical simulation experiments. The numerical simulation tests were performed under different normal stresses, joint inclination angles, and shear rates. The numerical experimental results show that the microscale failure of non-coplanar and discontinuously jointed rock masses is mainly caused by tensile cracks. Additionally, when the peak shear stress is reached, the growth rate of cracks increases rapidly, and the number of cracks increases with increasing normal stress. The shear strength of non-coplanar and discontinuously jointed rock masses increases with increasing normal stress. Under the same normal stress, the variation curves of the shear strength of non-coplanar and discontinuously jointed rock masses with respect to the dip angle exhibit an "S"-shaped nonlinear pattern. Rock masses with joint inclination angles of approximately 15° and 65° have minimum and maximum shear strengths, respectively. The joint dip angle has a significant impact on the final failure mode of rock bridges in the rock mass. As the joint dip angle increases, the final failure modes of rock bridges change from "end-to-end" connection to a combination of "head-to-head" and "tail-to-tail" connections. The shear rate has a certain impact on the peak shear stress, but the impact is not significant. The spatial distribution of the tensile force chains changes as shearing progresses, and stress concentration occurs at the tips of the original joints, which is the reason for the development of long tensile cracks in the deeper parts. [ABSTRACT FROM AUTHOR]

In this work, a multispectral aptasensor structure, including a sub-layer and two side walls, was presented. The cells are positioned at the down and top of the structure, with the down cells oriented perpendicular to the walls and the top cells aligned parallel to the walls. The validity of the findings was verified by the utilization of a numerical simulation technique known as 3D Finite Difference Time Domain (FDTD). The biosensor under consideration exhibits sensitivities of 1093.7 nm/RIU, 754 nm/RIU, and 707.43 nm/RIU in mode III, mode II, and mode I, respectively. In the majority of instances, the quantity of analyte available is insufficient to coat the surface of the sensor thoroughly. Consequently, in this study, the evaluation of surface sensitivity was undertaken alongside bulk sensitivity. The surface sensitivity of the suggested structure for mode II in the sensor layer, with thicknesses of 10, 20, 30, and 70 nm, is measured to be 25, 78, 344, and 717.636 nm/RIU, respectively. Our design incorporates a unique arrangement of sub-layer and side walls, with cells positioned to maximize interaction with the target analyte. This innovative configuration, combined with Ag for its superior plasmonic properties, enables the detection of E. coli O157 with remarkable sensitivity. [ABSTRACT FROM AUTHOR]

Parameter optimization (PO) methods to determine the ionic current composition of experimental cardiac action potential (AP) waveform have been developed using a computer model of cardiac membrane excitation. However, it was suggested that fitting a single AP record in the PO method was not always successful in providing a unique answer because of a shortage of information. We found that the PO method worked perfectly if the PO method was applied to a pair of a control AP and a model output AP in which a single ionic current out of six current species, such as IKr, ICaL, INa, IKs, IKur or IbNSC was partially blocked in silico. When the target was replaced by a pair of experimental control and IKr-blocked records of APs generated spontaneously in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), the simultaneous fitting of the two waveforms by the PO method was hampered to some extent by the irregular slow fluctuations in the Vm recording and/or sporadic alteration in AP configurations in the hiPSC-CMs. This technical problem was largely removed by selecting stable segments of the records for the PO method. Moreover, the PO method was made fail-proof by running iteratively in identifying the optimized parameter set to reconstruct both the control and the IKr-blocked AP waveforms. In the lead potential analysis, the quantitative ionic mechanisms deduced from the optimized parameter set were totally consistent with the qualitative view of ionic mechanisms of AP so far described in physiological literature. [ABSTRACT FROM AUTHOR]

To study the characteristics of nasal airflow in the presence of nasal cycle by computational fluid dynamics. CT scan data of a healthy Chinese individual was used to construct a three-dimensional model of the nasal cavity to be used as simulation domain. A sinusoidal airflow velocity is set at the nasal cavity entrance to reproduce the breathing pattern of a healthy human. There was a significant difference in the cross-sectional area between the two sides of the nasal cavity. Particularly, the decongested side is characterized by a larger cross-section area, and consequently, by a larger volume with respect to the congested side. The airflow velocity, pressure, and nasal resistance were higher on the congested narrow side. The temperature regulation ability on the congested narrow side was stronger than that on the decongested wider side. During the nasal cycle, there are differences in the nasal cavity function between the congested and decongested sides. Therefore, when evaluating the impact of various factors on nasal cavity function, the nasal cycle should be considered. [ABSTRACT FROM AUTHOR]

We numerically study the transport properties of a two-dimensional Fermi gas in a weakly and strongly interacting regimes, in the range of temperatures close to the transition to a superfluid phase. For that we excite sound waves in a fermionic mixture by using the phase imprinting technique, follow their evolution, and finally determine both their speed and attenuation. Our formalism, originated from a density-functional theory, incorporates thermal fluctuations via the grand canonical ensemble description and with the help of Metropolis algoritm. From numerical simulations we extract temperature dependence of the sound velocity and diffusivity as well as the dependence on the interaction strength. We emphasize the role of virtual vortex–antivortex pairs creation in the process of sound dissipation. [ABSTRACT FROM AUTHOR]

Applying causal inference methods, such as weighting and matching methods, to a survey sampled population requires properly incorporating the survey weights and design to obtain effect estimates that are representative of the target population and correct standard errors (SEs). With a simulation study, we compared various approaches for incorporating the survey weights and design into weighting and matching-based causal inference methods. When the models were correctly specified, most approaches performed well. However, when a variable was treated as an unmeasured confounder and the survey weights were constructed to depend on this variable, only the matching methods that used the survey weights in causal estimation and as a covariate in matching continued to perform well. If unmeasured confounders are potentially associated with the survey sample design, we recommend that investigators include the survey weights as a covariate in matching, in addition to incorporating them in causal effect estimation. Finally, we applied the various approaches to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and found that insomnia has a causal association with both mild cognitive impairment (MCI) and incident hypertension 6-7 years later in the US Hispanic/Latino population.

To examine the disparity in deformation behavior and mechanical qualities between anchor cables with C-shaped tubes and regular anchor cables under shear conditions. The double-sided shear tests of free-section anchor cables and anchor cables with C-shaped tubes were conducted utilizing the indoor large-scale double-shear test equipment with varying pretension loads. The indoor double-shear tests indicate that the inclusion of the C-shaped tube alters the stress distribution of the anchor cables inside the anchor cables with C-shaped tubes and mitigates the impact of stress concentration. Moreover, it facilitates the transition of the anchor cable's failure mode from a mix of tensile and shear breaking to mainly tensile breakage. In addition, ABAQUS finite element analysis software was used to establish a double shear test model of the anchor cable with C-shaped tube to accurately simulate the interaction and stress distribution among the anchor cable, C-shaped tube, and concrete block in the double shear test. The findings of the simulation results reveal that the numerical model can adequately depict the evolution of the stress distribution in the prestressed anchored structure and the damage of the concrete block with increasing shear displacement. The relational equation for the yield state of the anchor cable with C-shaped tube under combined tensile and shear loads is found by integrating the experimental and simulation data, the static beam theory, and the concept of minimal potential energy. [ABSTRACT FROM AUTHOR]

In this work, an analytical model to study graphene-based spatiotemporal modulated structures is developed and verified through comparison with full wave numerical simulations. Graphene is an ideal material for realizing spatiotemporal modulated structures at high frequencies of THz and optics. In this analysis, the electromagnetic response of studied structures is expressed in terms of weighted Floquet-Bloch modes supported by the structure, while graphene is modeled by a spatiotemporal modulated surface current that imposes certain boundary conditions on the modes. The developed analytical technique is a comprehensive tool and can be used for accurate modeling of different kinds of spatiotemporal devices including lossy, guided, and leaky wave structures. To demonstrate the accuracy of the model, two plasmonic waveguides with space and time modulated graphene conductivity are analyzed and their interband and intraband transition between modes are thoroughly investigated. Using the developed analytical model, spatiotemporal modulation phenomena such as mode conversion, wave amplification and nonreciprocal response are explored and discussed for the studied structures. [ABSTRACT FROM AUTHOR]

Based on computer simulations of a realistic discrete element model we demonstrate that shrinkage induced cracking of thin layers of heterogeneous materials, generating spectacular crack patterns, proceeds in bursts. These crackling pulses are characterized by scale free distributions of size and duration, however, with non-universal exponents depending on the system size and shrinking rate. On the contrary, local avalanches composed of micro-cracking events with temporal and spatial correlation are found to obey a universal power law statistics. Most notably, we demonstrate that the observed non-universality of the integrated signal is the consequence of the temporal superposition of the underlying local avalanches, which pop up in an uncorrelated way in homogeneous systems. Our results provide an explanation of recent acoustic emission measurements on drying induced shrinkage cracking and may have relevance for the acoustic monitoring of the electro-mechanical degradation of battery electrodes. [ABSTRACT FROM AUTHOR]

As cities have grown, conductor rail power supplies have been widely used in the field of urban rail transit. In order to improve the running performance of trains and reduce the occurrence of accidents, it is necessary to understand the vibration of shoegear-rail system under different initial contact forces and explore the dynamic performance of shoegear-rail system. Therefore, according to the structure of shoegear-rail system, a coupling model of shoegear-rail system is established in this paper. On the basis of the model, the numerical simulation of the shoegear-rail system under different initial contact forces is carried out, and finally the vibration data of the shoegear-rail system under different initial contact forces are obtained. The results show that with the increase of initial contact force in the range of 70–160 N, the vibration amplitude of the electric shoegear and the fluctuation amplitude of the contact force increase, but the maximum absolute shear force value of the conductor rail decreases. It indicates that the lower initial contact force, the better the performance of shoegear-rail system. [ABSTRACT FROM AUTHOR]

We perform numerical simulations to investigate the nonlinear propagation dynamics of femtosecond Gaussian and vortex beams in fused silica. By analyzing the extent of spectral broadening, we are able to distinguish between the linear, self-focusing, and filamentation regimes. Additionally, the maximum intensity and fluence distribution within the cross-section of the vortex beams are analyzed for different incident laser energies. The results demonstrate a direct correlation between the spectral broadening and the peak intensity of the femtosecond laser pulse. As a result, this provides a theoretical foundation for distinguishing different propagation regimes, and determining critical powers for self-focusing and filamentation of both femtosecond Gaussian and structured beams. [ABSTRACT FROM AUTHOR]

The high-frequency pulse flow, equivalent to the natural frequency of rocks, is generated by a self-excited oscillating cavity to achieve resonance rock-breaking. The flow field and oscillating mechanism of the self-excited oscillating cavity were simulated using the large eddy simulation method of Computational Fluid Dynamics (CFD). A field-scale testing apparatus was developed to investigate the impulse characteristics and verify the simulation results. The results show that the fluid at the outlet at the tool is deflected due to the pulse oscillation of the fluid. The size and shape of low-pressure vortices constantly change, leading to periodic changes in fluid impedance within the oscillating cavity. The impulse frequency reaches its highest point when the length–diameter ratio is 0.67. As the length–diameter ratio increases, the tool pressure loss also increases. Regarding the cavity thickness, the impulse frequency of the oscillating cavity initially decreases, then increases, and finally decreases again. Moreover, both the impulse frequency and pressure loss increase with an increase in displacement. The numerical simulation findings align with the experimental results, thus confirming the validity of the theoretical model. This research provides theoretical guidance for the practical application of resonance rock-breaking technology. [ABSTRACT FROM AUTHOR]

This study analyses the impact of initial conditions on the results of numerical simulations of the fan load with underwater detonation and simultaneously typical harmonic loads from the operating device. It was shown that different initial conditions affect both displacement and velocity results. Furthermore, significant differences were indicated when comparing the results with devices without harmonic loads. The results indicate the need for more detailed analyses at the initial stage of modelling the impact resistance of devices planned for ship installation. [ABSTRACT FROM AUTHOR]

Due to its challenging manufacturing and intricate morphology, the aluminum alloy transmission intermediate shell used in vehicle transmission has been the focus of many academic studies. In this study, the three-dimensional cutting model is condensed to a two-dimensional cutting model and utilized to simulate the finishing process of an aluminum alloy workpiece using the finite element modeling program DEFORM-3D. Through orthogonal testing and range analysis, the impact of integral end mill side edge parameters on cutting performance was investigated. It is determined that tool chamfering has a greater impact on cutting performance than tool rake and relief angles, that chamfering width has the most impact on cutting force, and that chamfering angle has the greatest impact on cutting temperature. The workpiece's surface roughness is tested during a cutting experiment, and an analysis of the data reveals that the finite element simulation model is accurate and the orthogonal test method is reasonable. The tool chamfer has a greater impact on roughness than the tool rake angle and relief angle. The tool settings are further optimized using the firefly method. By examining the data, it is determined that the prediction model is correct and the optimization model is reasonable. The cutting efficiency is higher and the surface quality is better when the chamfer width is 0.17 mm and the chamfer angle is 7.3° or 18.3°. Therefore, optimizing the side edge parameters of the integral end mill during the finishing process of a thin-walled aluminum alloy shell has practical technical value. [ABSTRACT FROM AUTHOR]

In this study, we investigated the destructive effect of autoclaved aerated concrete (AAC) masonry walls subjected to close-in explosions. First, full-size refined finite-element models of the AAC masonry wall were established, and the accuracy of the models was verified by comparison with the test results. The destruction pattern and damage characteristics of the AAC wall were studied, and the effects of block size, wall thickness, mortar compressive strength, and explosion distance on the destruction degree of the AAC masonry walls were analyzed. The results showed that the destruction pattern of the AAC masonry wall subjected to close-in explosion manifested as punching damage in the middle of the wall. When the scaled distance remained unchanged, the punching damage area of the AAC masonry wall was positively correlated with the block size and negatively correlated with the wall thickness and mortar compressive strength. When the explosive equivalent remained unchanged and the explosion distance increased, the punching damage area first increased and then decreased. According to the damage mechanism of the AAC masonry wall, a calculation method for predicting the punching damage area of the AAC masonry wall was established, and the accuracy of this method was verified by comparing it with the numerical results. In addition, the damage criterion based on the punching damage area was established to determine the destruction levels of AAC masonry walls. [ABSTRACT FROM AUTHOR]

The freezing damage of rock tunnels in cold region involves ice-water phase change and complicated interaction of Thermo–Hydro–Mechanical (THM) field. Taking the fractured rock mass of cold region tunnels as research subject, the THM coupling model of cold region tunnels was established, which is based on the seepage mechanics, heat transfer theory, damage mechanics and equivalent continuum theory. This model could reflect the anisotropic properties of deformation, water migration and heat transfer caused by the initial fracture of rock mass. The construction and operation processes of a rock tunnel in cold region were simulated, and results were compared with the measured value and predecessor's achievements. It shows that proposed model could reflect the anisotropic property of surrounding rock and the simulated deformation and stress are not symmetrical. Compared with the literature, the calculated results in this paper are closer to the measured values. The insulating layer has a significant effect on the stress of the supporting structures. The maximum tension stress of the lining is 4.5 times as that without insulating layer, and the lining will be destroyed for the overlarge tension stress. [ABSTRACT FROM AUTHOR]

The finite difference model and particle flow model were constructed to reproduce the process of coal and gas outburst in front of the tunnel. The reliability of the particle flow model was verified by studying the internal stress, gas pressure, and related parameters of gas and coal two-phase flow. Then the process of coal and gas outburst is described from a microscopic perspective. The results show that the particle flow numerical model of coal and gas outburst is in line with reality and can intuitively and conveniently monitor relevant parameters; The concentrated stress caused by excavation of tunnels can reach 1.2 times the in-situ stress; High stress causes the adhesion between coal particles to break down, which is the main reason for the initiation of coal and gas outbursts; The intermittent breakthrough of gas on the coal particle collection that blocks the release channel has caused pulsating characteristics of coal and gas outbursts. [ABSTRACT FROM AUTHOR]

The objective of this study is to develop the S E I A R S epidemic model for C O V I D - 19 utilizing the ψ -Caputo fractional derivative. The reproduction number ( R ˘ 0 ) is calculated utilizing the next generation matrix method. The equilibrium points of the model are computed, and both the local and global stability of the disease-free equilibrium point are demonstrated. Sensitivity analysis is discussed to describe the importance of the parameters and to demonstrate the existence of a unique solution for the model by applying a fixed point theorem. Utilizing the fractional Euler procedure, an approximate solution to the model is obtained. To study the transmission dynamics of infection, numerical simulations are conducted by using MatLab. Both numerical methods and simulations can provide valuable insights into the behavior of the system and help in understanding the existence and properties of solutions. By placing the values t , ln (t) and t instead of ψ , the derivatives of the Caputo and Caputo–Hadamard and Katugampola appear, respectively, to compare the results of each with real data. Besides, these simulations specifically with different fractional orders to examine the transmission dynamics. At the end, we come to the conclusion that the simulation utilizing Caputo derivative with the order of 0.95 shows the prevalence of the disease better. Our results are new which provide a good contribution to the current research on this field of research. [ABSTRACT FROM AUTHOR]

The fatigue life and cutting performance of conical pick is essential for the roadheader machine in the excavation engineering. In rock breaking process, the rock structural conditions has a certain influence on the rock breaking and rock damage with roadheader breaking rock. Established the simulation model of conical pick cutting jointed rock to investigate the influence of the rock joint, rock bedding and confining pressure on the cutting performance and fatigue life of conical pick and rock damage. And the MATLAB is applied to solve the difficulty of rock damage statistical analysis. The research results indicated that the cutting force decreases with the rock joint length increasing, the cutting force increases first and decreases with the rock bedding angle increasing, however, the cutting force decreases first and then increases with the confining pressure increasing. The rock damage has a great relationship with the rock joint, rock bedding and confining pressure. The rock damage increases first and decreases then with the rock joint increasing and the rock bedding angle increasing. However, the influence of confining pressure on rock damage is contrary. Meanwhile, the rock fracture volume is positively correlated with damage value. The research results indicated that the rock structural parameters have an obvious influence on conical pick cutting performance and rock damage. [ABSTRACT FROM AUTHOR]

In this work, a fully 3D-printed choke corrugated Gaussian profile horn antenna (GPHA) using high-conductive filaments and a low-cost modular 3D-printing technique is implemented. The choke corrugated GPHA operates in the Ka-band, with a central frequency of 28 GHz. Although the antenna can be printed in one piece as its dimensions are within the printing limits, four pieces compose the three sections of the final 3D-printed antenna. The numerical simulations and measurements of the antenna show a good agreement, validating the possibility of cost-effective modular fabrication of this complex type of antennas. [ABSTRACT FROM AUTHOR]

With the slowdown of improvement in conventional von Neumann systems, increasing attention is paid to novel paradigms such as Ising machines. They have very different approach to solving combinatorial optimization problems. Ising machines have shown great potential in solving binary optimization problems like MaxCut. In this paper, we present an analysis of these systems in boolean satisfiability (SAT) problems. We demonstrate that, in the case of 3-SAT, a basic architecture fails to produce meaningful acceleration, largely due to the relentless progress made in conventional SAT solvers. Nevertheless, careful analysis attributes part of the failure to the lack of two important components: cubic interactions and efficient randomization heuristics. To overcome these limitations, we add proper architectural support for cubic interaction on a state-of-the-art Ising machine. More importantly, we propose a novel semantic-aware annealing schedule that makes the search-space navigation much more efficient than existing annealing heuristics. Using numerical simulations, we show that such an "Augmented" Ising Machine for SAT is projected to outperform state-of-the-art software-based, GPU-based and conventional hardware SAT solvers by orders of magnitude. [ABSTRACT FROM AUTHOR]

Compared to normal arc-related volcanic eruptions, the formation of a volcanic caldera is a relatively atypical event. During caldera formation a series of large volumes of magma are erupted, reducing the structural support for the rock above the magma chamber and creating a large depression at the surface called caldera. Los Humeros volcanic field (LHVF) represents one of the largest volcanic calderas in Mexico. It is located some 400 km from the trench at the eastern edge of the Trans Mexican Volcanic Belt where the depth to the Cocos slab is more than 300 km. In this study we employ high-resolution two-dimensional thermomechanical numerical simulations of magma intrusions and a horizontal tectonic strain rate to better understand the influence of crustal deformation for the formation of Los Humeros caldera. A minimum number of three thermal anomaly pulses of hydrated mantle material (with diameter of 15 km or more) and a regional strain rate of 7.927 × 10–16 s−1 are required for magma to reach the surface. Modeling results show that regional extension coupled with deep thermal anomalies (with a temperature excess of ΔT ≥ 100 °C) that come in a specific chain-type sequence produce surface deformation patterns similar to LHVF. We propose an asthenospheric sub-slab deep source (> 300 km depth) for the thermal anomalies where previous studies showed the existence of a gap or tear in the Cocos slab. [ABSTRACT FROM AUTHOR]

To address the problem of excessive local secondary stripping between adjacent mining areas in open pit mines caused by internal row raising, a multivariate function was fitted to the model of the main mining seam of Zhundong open pit coal mine in Xinjiang, and the different locations of the end gang of the second mining area were divided into multiple sections at certain step sizes and calculated by integration, resulting in stripping ratios for each section, which were fitted to a stripping ratio curve. The optimal location of the mining area boundary was found to be 55 m westward offset from the mining area boundary in the inner row of the raised section, and numerical simulations based on the strength reduction method were applied to analyse the slope stability of the end gang at this location. The results of the study show that the analysed slope meets the stability requirements and the optimised new boundary avoids the stripping of approximately 65,837,376 m3 of economically unreasonable section. [ABSTRACT FROM AUTHOR]

Using a semidiscretization method, we derive in this paper a discrete slow-fast predator-prey system with ratio-dependent functional response. First of all, a detailed study for the local stability of fixed points of the system is obtained by invoking an important lemma. In addition, by utilizing the center manifold theorem and the bifurcation theory some sufficient conditions are obtained for the transcritical bifurcation and Neimark-Sacker bifurcation of this system to occur. Finally, with the use of Matlab software, numerical simulations are carried out to illustrate the corresponding theoretical results and reveal some new dynamics of the system. Our results clearly demonstrate that the system is very sensitive to its fast time scale parameter variable. [ABSTRACT FROM AUTHOR]

The field-dependent relaxation dynamics of suspended magnetic nanoparticles continues to present a fascinating topic of basic science that at the same time is highly relevant for several technological and biomedical applications. Renewed interest in the intriguing behavior of magnetic nanoparticles in response to external fields has at least in parts be driven by rapid advances in magnetic fluid hyperthermia research. Although a wealth of experimental, theoretical, and simulation studies have been performed in this field in recent years, several contradictory findings have so far prevented the emergence of a consistent picture. Here, we present a dynamic mean-field theory together with comprehensive computer simulations of a microscopic model system to systematically discuss the influence of several key parameters on the relaxation dynamics, such as steric and dipolar interactions, the external magnetic field strength and frequency, as well as the ratio of Brownian and Néel relaxation time. We also discuss the specific and intrinsic loss power as measures of the efficiency of magnetic fluid heating and discuss optimality conditions in terms of fluid and field parameters. Our results are helpful to reconcile contradictory findings in the literature and provide an important step towards a more consistent understanding. In addition, our findings also help to select experimental conditions that optimize magnetic fluid heating applications. [ABSTRACT FROM AUTHOR]

Simple analytical formulas are proposed to describe the plasma potential in a steady-state magnetron discharge, based on the results of various experiments and numerical simulations reported in the literature. The description is two-dimensional (2D), covering two main regions, the cathode sheath and the ionization region, both contributing to electron energization. A parabolic potential in the axial direction governs the cathode sheath. The thickness of the cathode sheath is obtained from the 1D collisionless Child–Langmuir law. A parabolic or linear potential in the axial direction characterizes the ionization region. The local ion current density to the cathode, estimated from the target erosion profile, sets the radial dependence of the potential. The proposed formulas use a set of input parameters that can be experimentally obtained. The analytical description captures all characteristics of the highly inhomogeneous plasma potential of a steady-state magnetron discharge operated in a reduced magnetic field BRT/p lower than 0.1 T/Pa, as revealed by the comparison to self-consistent 2D numerical simulations. [ABSTRACT FROM AUTHOR]

One of the fundamental quantities in dynamics of the liquid state, the adiabatic speed of sound c s , is extremely difficult to predict from computer simulations, especially in ab initio simulations. Here we derive an expression for the instantaneous correlator of fluctuations of longitudinal component of stress tensor, which contains c s along with others quantities easy accessible via classical and ab initio computer simulations. We show that the proposed methodology works well in the case of Lennard-Jones and soft-sphere simple fluids, Kr–Ar liquid mixture in connection with simulations with effective pair interactions as well as for liquid Sb, fluid Hg and molten NaCl from ab initio simulations. [ABSTRACT FROM AUTHOR]

This work provides numerical simulations of the nonlinear breathing transmission epidemic system using the proposed stochastic scale conjugate gradient neural networks (SCGGNNs) procedure. The mathematical model categorizes the breathing transmission epidemic model into four dynamics based on a nonlinear stiff ordinary differential system: susceptible, exposed, infected, and recovered. Three different cases of the model are taken and numerically presented by applying the stochastic SCGGNNs. An activation function 'log-sigmoid' uses twenty neurons in the hidden layers. The precision of SCGGNNs is obtained by comparing the proposed and database solutions. While the negligible absolute error is performed around 10–06 to 10–07, it enhances the accuracy of the scheme. The obtained results of the breathing transmission epidemic system have been provided using the training, verification, and testing procedures to reduce the mean square error. Moreover, the exactness and capability of the stochastic SCGGNNs are approved through error histograms, regression values, correlation tests, and state transitions. [ABSTRACT FROM AUTHOR]

This study investigates the 3D flow properties and heat transfer of copper, titanium/ water nanofluids across a bidirectional surface under the impact of MHD. The thermophysical features of nanofluid are employed using the Tiwari and Das model. Boundary layer theory has simplified the resulting physical principles. By using the proper transformations, the complicated sets of connected PDEs have evolved into ODEs. Equations that have been modify by using OHAM. For various dimensionless component ranges between 2 ≤ M ≤ 10 . 0 ≤ a ≤ 3 , 0.05 ≤ φ ≤ 0.08 , 3 ≤ Pr ≤ 8 , 0 ≤ R d ≤ 6 , and 2 ≤ λ ≤ 4 the results are investigated computationally and graphically. It is observed that fluid parameters improve; they react differently from temperature and velocity profile. Additionally, thermal profiles decrease in comparison to greater Eckert and Prandtl numbers. [ABSTRACT FROM AUTHOR]