1. Prevalence of elevated serum fatty acid synthase in chronic limb-threatening ischemia
- Author
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Shirli Tay, Kshitij A. Desai, Nikolai Harroun, Yan Yan, Mohamed A. Zayed, Clay F. Semenkovich, Gayan S. De Silva, Amanda Penrose, and Connor Engel
- Subjects
Adult ,Chronic Limb-Threatening Ischemia ,Male ,medicine.medical_specialty ,Apolipoprotein B ,Science ,Ischemia ,Diseases ,Pathogenesis ,Type 2 diabetes ,Femoral artery ,Severity of Illness Index ,Gastroenterology ,Article ,Internal medicine ,medicine.artery ,medicine ,Humans ,Aged ,Multidisciplinary ,biology ,Histocytochemistry ,business.industry ,Proteins ,Middle Aged ,medicine.disease ,Lipids ,Enzymes ,Fatty Acid Synthase, Type I ,Fatty acid synthase ,Cross-Sectional Studies ,Concomitant ,Preoperative Period ,Enzyme mechanisms ,biology.protein ,Medicine ,Female ,Preoperative fasting ,business ,Biomarkers - Abstract
There are currently no serum-based evaluations that can corroborate the severity of peripheral artery disease (PAD). In this cross-sectional study, we assessed the prevalence of elevated serum fatty acid synthase (cFAS) in patients with chronic limb-threatening ischemia (CLTI) and evaluated the accuracy of its use in detecting this condition. Preoperative fasting serum samples from 87 patients undergoing vascular intervention were collected between October 2014 and September 2016. Median age was 62 years, with 56 (64%) men, and 32 (37%) with CLTI. We found that elevated cFAS content (OR 1.17; 95% CI 1.04–1.31), type 2 diabetes (T2D; OR 5.22; 95% CI 1.77–15.4), and smoking (OR 3.53; 95% CI 1.19–10.5) were independently associated with CLTI and could detect the presence of CLTI with 83% accuracy (95% CI 0.74–0.92). Furthermore, serum FAS content was positively correlated with FAS content in femoral artery plaque in patients with severe PAD ($${R}^{2}$$ R 2 = 0.22; P = 0.023). Finally, significantly higher co-localization of FAS and ApoB were observed within lower extremity arterial media (P
- Published
- 2021
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