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Abstract In this report, we demonstrate a versatile method for the removal of bone cement fumes from the vicinity of health care workers in a simulated operating room. The mixing of two component bone cement in the perimeter of an operating room releases volatile organic compounds (VOCs). The use of localized negative pressure within proximity of the mixing vessel is expected to reduce the concentration of VOCs dispersed near the airway of operating room personnel. A standard two component bone cement formulation was mixed in the perimeter of a simulated operating room. A median VOC concentration of 19 ppm was detected with a portable VOC detector. When a portable negative pressure unit was stationed near the mixing area at distances of 8 and 36 cm from the mixing vessel, the median VOC rise was reduced by approximately 97% and 83%, respectively, relative to the control. The use of a portable negative pressure unit provides a potential increase in the safety for all staff when working with materials that give off VOCs in the operating room.