27 results on '"Dong, Ju"'
Search Results
2. CHI3L1 induces autophagy through the JNK pathway in lung cancer cells
- Author
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Hong, Da Eun, Yu, Ji Eun, Yoo, Seung Sik, Yeo, In Jun, Son, Dong Ju, Yun, Jaesuk, Han, Sang-Bae, and Hong, Jin Tae
- Published
- 2023
- Full Text
- View/download PDF
3. Mesenchymal stem cells enhance CCL8 expression by podocytes in lupus-prone MRL.Fas lpr mice
- Author
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Hyung Sook Kim, Hong Kyung Lee, Kihyeon Kim, Gi Beom Ahn, Min Sung Kim, Tae Yong Lee, Dong Ju Son, Youngsoo Kim, Jin Tae Hong, and Sang-Bae Han
- Subjects
Medicine ,Science - Abstract
Abstract Nephritis is common in systemic lupus erythematosus patients and is associated with hyper-activation of immune and renal cells. Although mesenchymal stem cells (MSCs) ameliorate nephritis by inhibiting T and B cells, whether MSCs directly affect renal cells is unclear. To address this issue, we examined the direct effect of MSCs on renal cells with a focus on chemokines. We found that expression of CCL2, CCL3, CCL4, CCL5, CCL8, CCL19, and CXCL10 increased 1.6–5.6-fold in the kidney of lupus-prone MRL.Fas lpr mice with advancing age from 9 to 16 weeks. Although MSCs inhibited the increase in the expression of most chemokines by 52–95%, they further increased CCL8 expression by 290%. Using renal cells, we next investigated how MSCs enhanced CCL8 expression. CCL8 was expressed by podocytes, but not by tubular cells. MSCs enhanced CCL8 expression by podocytes in a contact-dependent manner, which was proved by transwell assay and blocking with anti-VCAM-1 antibody. Finally, we showed that CCL8 itself activated MSCs to produce more immunosuppressive factors (IL-10, IDO, TGF-β1, and iNOS) and to inhibit more strongly IFN-γ production by T cells. Taken together, our data demonstrate that MSCs activate podocytes to produce CCL8 in a contact-dependent manner and conversely, podocyte-derived CCL8 might potentiate immunosuppressive activity of MSCs in a paracrine fashion. Our study documents a previously unrecognized therapeutic mechanism of MSCs in nephritis.
- Published
- 2023
- Full Text
- View/download PDF
4. CHI3L1 induces autophagy through the JNK pathway in lung cancer cells
- Author
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Da Eun Hong, Ji Eun Yu, Seung Sik Yoo, In Jun Yeo, Dong Ju Son, Jaesuk Yun, Sang-Bae Han, and Jin Tae Hong
- Subjects
Medicine ,Science - Abstract
Abstract CHI3L1 is closely related to the molecular mechanisms of cancer cell migration, growth, and death. According to recent research, autophagy regulates tumor growth during various stages of cancer development. This study examined the association between CHI3L1 and autophagy in human lung cancer cells. In CHI3L1-overexpressing lung cancer cells, the expression of LC3, an autophagosome marker, and the accumulation of LC3 puncta increased. In contrast, CHI3L1 depletion in lung cancer cells decreased the formation of autophagosomes. Additionally, CHI3L1 overexpression promoted the formation of autophagosomes in various cancer cell lines: it also increased the co-localization of LC3 and the lysosome marker protein LAMP-1, indicating an increase in the production of autolysosomes. In mechanism study, CHI3L1 promotes autophagy via activation of JNK signaling. JNK may be crucial for CHI3L1-induced autophagy since pretreatment with the JNK inhibitor reduced the autophagic effect. Consistent with the in vitro model, the expression of autophagy-related proteins was downregulated in the tumor tissues of CHI3L1-knockout mice. Furthermore, the expression of autophagy-related proteins and CHI3L1 increased in lung cancer tissues compared with normal lung tissues. These findings show that CHI3L1-induced autophagy is triggered by JNK signals and that CHI3L1-induced autophagy could be a novel therapeutic approach to lung cancer.
- Published
- 2023
- Full Text
- View/download PDF
5. Moxifloxacin releasing intraocular implant based on a cross-linked hyaluronic acid membrane
- Author
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Dong Ju Kim, Mi-Young Jung, Joo-Hee Park, Ha-Jin Pak, Martha Kim, Roy S. Chuck, and Choul Yong Park
- Subjects
Medicine ,Science - Abstract
Abstract Intraocular antibiotic delivery is an important technique to prevent bacterial infection after ophthalmic surgery, such as cataract surgery. Conventional drug delivery methods, such as antibiotic eye drops, have limitations for intraocular drug delivery due to the intrinsic barrier effect of the cornea. Therefore, frequent instillation of antibiotic eyedrops is necessary to reach a sufficient bactericidal concentration inside the eye. In this study, an intraocular implant, MXF-HA, that combines hyaluronic acid (HA) and moxifloxacin (MXF) was developed to increase the efficiency of intraocular drug delivery after surgery. MXF-HA is manufactured as a thin, transparent, yellow-tinted membrane. When inserted into the eye in a dry state, MXF-HA is naturally hydrated and settles in the eye, and the MXF contained therein is delivered by hydrolysis of the polymer over time. It was confirmed through in vivo experiments that MXF delivery was maintained in the anterior chamber of the eye at a concentration sufficient to inhibit Pseudomonas aeruginosa and Staphylococcus aureus for more than 5 days after implantation. These results suggest that MXF-HA can be utilized as a potential drug delivery method for the prevention and treatment of bacterial infections after ophthalmic surgery.
- Published
- 2021
- Full Text
- View/download PDF
6. Impact of preoperative renal replacement therapy on the clinical outcome of heart transplant patients
- Author
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Darae Kim, Jin-Oh Choi, Yang Hyun Cho, Kiick Sung, Jaewon Oh, Hyun Jai Cho, Sung-Ho Jung, Hae-Young Lee, Jin Joo Park, Dong-Ju Choi, Seok-Min Kang, Jae-Joong Kim, and Eun-Seok Jeon
- Subjects
Medicine ,Science - Abstract
Abstract Renal dysfunction is considered as a relative contraindication for heart transplantation (HTx). However, in the real world setting, many patients with advanced heart failure (HF) experience worsening of renal function and some even require renal replacement therapy (RRT) by the time they undergo HTx. We aimed to investigate the prognosis and clinical outcomes of HTx patients who required RRT during the perioperative period. The Korean Organ Transplant Registry (KOTRY) is a nationwide organ transplant registry in Korea. A total of 501 HTx patients had been prospectively enrolled in the KOTRY registry during 2014–2018. Among the 501 patients, 13 underwent combined heart and kidney transplantation (HKTx). The 488 patients who underwent isolated HTx were grouped according to their pre- and postoperative RRT status. The primary outcome was progression to dialysis-dependent end-stage renal disease (ESRD) after HTx. The secondary outcome was all-cause mortality after HTx. The median follow-up was 22 months (9–39 months). Patients who needed preoperative RRT but were free from postoperative RRT showed comparable overall survival and renal outcome to patients who were free from both pre- and postoperative RRT. In multivariable analysis, preoperative RRT was not associated with progression to ESRD or all-cause mortality after HTx; however, postoperative RRT was a significant predictor for both progression to ESRD and all-cause mortality after HTx. Preoperative creatinine or estimated glomerular filtration rate (eGFR) were not predictive of progression to ESRD after HTx. The present analysis suggests that preoperative RRT requirement does not indicate irreversible renal dysfunction in patients waiting for HTx. However, postoperative RRT was associated with progression to ESRD and mortality after HTx.
- Published
- 2021
- Full Text
- View/download PDF
7. Development of a novel hyaluronic acid membrane for the treatment of ocular surface diseases
- Author
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Dong Ju Kim, Mi-Young Jung, Ha-Jin Pak, Joo-Hee Park, Martha Kim, Roy S. Chuck, and Choul Yong Park
- Subjects
Medicine ,Science - Abstract
Abstract Ocular surface diseases (OSD) can cause serious visual deterioration and discomfort. Commercial artificial tear solution containing hyaluronic acid (HA) show excellent biocompatibility and unique viscoelastic characteristics. Here, we developed a novel HA membrane (HAM) by chemical crosslinking using 1,4-butanediol diglycidyl ether for the effective treatment of OSDs. The main purpose of HAMs is to provide sustained release of HA to modulate the wound healing response in OSDs. The safety and efficacy of HAMs were investigated using primary cultured human corneal epithelial cells and various OSD rabbit models. In the dry state, the HAM is firm, transparent, and easy to manipulate. When hydrated, it swells rapidly with high water retention and over 90% transmission of visible light. Human corneal epithelial cells and rabbit eyes showed no toxic response to HAM. Addition of HAMs to the culture medium enhanced human corneal epithelial cell viability and expression of cell proliferation markers. Investigation of HAM wound healing efficacy using mechanical or chemical corneal trauma and conjunctival surgery in rabbits revealed that application of HAMs to the ocular surface enhanced healing of corneal epithelium and reduced corneal limbal vascularization, opacity and conjunctival fibrosis. The therapeutic potential of HAMs in various OSDs was successfully demonstrated.
- Published
- 2021
- Full Text
- View/download PDF
8. Impact of preoperative renal replacement therapy on the clinical outcome of heart transplant patients
- Author
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Kim, Darae, Choi, Jin-Oh, Cho, Yang Hyun, Sung, Kiick, Oh, Jaewon, Cho, Hyun Jai, Jung, Sung-Ho, Lee, Hae-Young, Park, Jin Joo, Choi, Dong-Ju, Kang, Seok-Min, Kim, Jae-Joong, and Jeon, Eun-Seok
- Published
- 2021
- Full Text
- View/download PDF
9. Development of a novel hyaluronic acid membrane for the treatment of ocular surface diseases
- Author
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Kim, Dong Ju, Jung, Mi-Young, Pak, Ha-Jin, Park, Joo-Hee, Kim, Martha, Chuck, Roy S., and Park, Choul Yong
- Published
- 2021
- Full Text
- View/download PDF
10. Moxifloxacin releasing intraocular implant based on a cross-linked hyaluronic acid membrane
- Author
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Kim, Dong Ju, Jung, Mi-Young, Park, Joo-Hee, Pak, Ha-Jin, Kim, Martha, Chuck, Roy S., and Park, Choul Yong
- Published
- 2021
- Full Text
- View/download PDF
11. Assessment of the nutritional status of 6–36-month-old infants in Xinjiang and analysis of the influencing factors
- Author
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Wei, Meng, Li, Jing, Yan, Mei, Rena, Maimaiti, Zhang, Hui, and Dong, Ju
- Published
- 2020
- Full Text
- View/download PDF
12. Effect of Nitric Oxide on Human Corneal Epithelial Cell Viability and Corneal Wound Healing
- Author
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Joo-Hee Park, Ja-Yeon Kim, Dong Ju Kim, Martha Kim, Minwook Chang, Roy S. Chuck, and Choul Yong Park
- Subjects
Medicine ,Science - Abstract
Abstract Although the wound healing effects of nitric oxide (NO) are known, the mechanism by which NO modulates corneal wound healing remains unclear. In this study, we investigated the effect of exogenous NO donor (NaNO2) on corneal wound healing. We found that NaNO2 (0.1 μM to 100 μM) increased human corneal epithelial cell (HCEC) viability and migration. It also modulated the phosphorylation of mitogen-activated protein kinases (MAPKs) in a time- dependent manner in those HCECs. Further, p38 MAPK phosphorylation increased at 6 h and normalized at 24 h, while the phosphorylation of extracellular signal regulated kinase (ERK) was increased both at 6 h and 24 h. Topical treatment with NaNO2 (10 μM) enhanced corneal epithelial healing and decreased corneal opacity in murine corneal alkali burn model by modulating inflammatory cytokines. Our findings suggest that NO increased HCEC proliferation and migration via time-dependent MAPK activation and eventually enhanced corneal recovery from the alkali burn.
- Published
- 2017
- Full Text
- View/download PDF
13. Mesenchymal stem cells enhance CCL8 expression by podocytes in lupus-prone MRL.Faslpr mice.
- Author
-
Kim, Hyung Sook, Lee, Hong Kyung, Kim, Kihyeon, Ahn, Gi Beom, Kim, Min Sung, Lee, Tae Yong, Son, Dong Ju, Kim, Youngsoo, Hong, Jin Tae, and Han, Sang-Bae
- Subjects
MESENCHYMAL stem cells ,SYSTEMIC lupus erythematosus ,T cells ,B cells - Abstract
Nephritis is common in systemic lupus erythematosus patients and is associated with hyper-activation of immune and renal cells. Although mesenchymal stem cells (MSCs) ameliorate nephritis by inhibiting T and B cells, whether MSCs directly affect renal cells is unclear. To address this issue, we examined the direct effect of MSCs on renal cells with a focus on chemokines. We found that expression of CCL2, CCL3, CCL4, CCL5, CCL8, CCL19, and CXCL10 increased 1.6–5.6-fold in the kidney of lupus-prone MRL.Fas
lpr mice with advancing age from 9 to 16 weeks. Although MSCs inhibited the increase in the expression of most chemokines by 52–95%, they further increased CCL8 expression by 290%. Using renal cells, we next investigated how MSCs enhanced CCL8 expression. CCL8 was expressed by podocytes, but not by tubular cells. MSCs enhanced CCL8 expression by podocytes in a contact-dependent manner, which was proved by transwell assay and blocking with anti-VCAM-1 antibody. Finally, we showed that CCL8 itself activated MSCs to produce more immunosuppressive factors (IL-10, IDO, TGF-β1, and iNOS) and to inhibit more strongly IFN-γ production by T cells. Taken together, our data demonstrate that MSCs activate podocytes to produce CCL8 in a contact-dependent manner and conversely, podocyte-derived CCL8 might potentiate immunosuppressive activity of MSCs in a paracrine fashion. Our study documents a previously unrecognized therapeutic mechanism of MSCs in nephritis. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
14. Development of a novel hyaluronic acid membrane for the treatment of ocular surface diseases
- Author
-
Joo Hee Park, Martha Kim, Choul Yong Park, Mi Young Jung, Roy S. Chuck, Ha Jin Pak, and Dong Ju Kim
- Subjects
medicine.medical_specialty ,Biocompatibility ,genetic structures ,Corneal diseases ,medicine.medical_treatment ,Science ,02 engineering and technology ,Article ,Cell Line ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Conjunctival diseases ,Fibrosis ,Ophthalmology ,Spectroscopy, Fourier Transform Infrared ,Hyaluronic acid ,medicine ,Animals ,Humans ,Hyaluronic Acid ,Corneal epithelium ,Wound Healing ,Multidisciplinary ,Chemistry ,Cell growth ,Epithelium, Corneal ,virus diseases ,food and beverages ,Membranes, Artificial ,021001 nanoscience & nanotechnology ,medicine.disease ,eye diseases ,Artificial tears ,Membrane ,medicine.anatomical_structure ,Microscopy, Electron, Scanning ,030221 ophthalmology & optometry ,Medicine ,Rabbits ,sense organs ,0210 nano-technology ,Wound healing - Abstract
Ocular surface diseases (OSD) can cause serious visual deterioration and discomfort. Commercial artificial tear solution containing hyaluronic acid (HA) show excellent biocompatibility and unique viscoelastic characteristics. Here, we developed a novel HA membrane (HAM) by chemical crosslinking using 1,4-butanediol diglycidyl ether for the effective treatment of OSDs. The main purpose of HAMs is to provide sustained release of HA to modulate the wound healing response in OSDs. The safety and efficacy of HAMs were investigated using primary cultured human corneal epithelial cells and various OSD rabbit models. In the dry state, the HAM is firm, transparent, and easy to manipulate. When hydrated, it swells rapidly with high water retention and over 90% transmission of visible light. Human corneal epithelial cells and rabbit eyes showed no toxic response to HAM. Addition of HAMs to the culture medium enhanced human corneal epithelial cell viability and expression of cell proliferation markers. Investigation of HAM wound healing efficacy using mechanical or chemical corneal trauma and conjunctival surgery in rabbits revealed that application of HAMs to the ocular surface enhanced healing of corneal epithelium and reduced corneal limbal vascularization, opacity and conjunctival fibrosis. The therapeutic potential of HAMs in various OSDs was successfully demonstrated.
- Published
- 2021
15. Impact of preoperative renal replacement therapy on the clinical outcome of heart transplant patients
- Author
-
Hyun Jai Cho, Kiick Sung, Yang Hyun Cho, Jin-Oh Choi, Sung Ho Jung, Hae Young Lee, Eun Seok Jeon, Jae Joong Kim, Jaewon Oh, Dong-Ju Choi, Seok Min Kang, Jin Joo Park, and Darae Kim
- Subjects
Male ,medicine.medical_treatment ,Transplants ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,Kidney ,Organ transplantation ,0302 clinical medicine ,Risk Factors ,030212 general & internal medicine ,Prospective Studies ,Kidney transplantation ,Heart transplantation ,Multidisciplinary ,Acute Kidney Injury ,Middle Aged ,Prognosis ,female genital diseases and pregnancy complications ,Renal Replacement Therapy ,Creatinine ,Cardiology ,Disease Progression ,Medicine ,Female ,Glomerular Filtration Rate ,Adult ,medicine.medical_specialty ,Science ,Renal function ,Article ,03 medical and health sciences ,Renal Dialysis ,Internal medicine ,Preoperative Care ,medicine ,Humans ,Renal replacement therapy ,Contraindication ,Aged ,Heart Failure ,business.industry ,Health care ,Perioperative ,medicine.disease ,Kidney Transplantation ,Heart failure ,Heart Transplantation ,Kidney Failure, Chronic ,business - Abstract
Renal dysfunction is considered as a relative contraindication for heart transplantation (HTx). However, in the real world setting, many patients with advanced heart failure (HF) experience worsening of renal function and some even require renal replacement therapy (RRT) by the time they undergo HTx. We aimed to investigate the prognosis and clinical outcomes of HTx patients who required RRT during the perioperative period. The Korean Organ Transplant Registry (KOTRY) is a nationwide organ transplant registry in Korea. A total of 501 HTx patients had been prospectively enrolled in the KOTRY registry during 2014–2018. Among the 501 patients, 13 underwent combined heart and kidney transplantation (HKTx). The 488 patients who underwent isolated HTx were grouped according to their pre- and postoperative RRT status. The primary outcome was progression to dialysis-dependent end-stage renal disease (ESRD) after HTx. The secondary outcome was all-cause mortality after HTx. The median follow-up was 22 months (9–39 months). Patients who needed preoperative RRT but were free from postoperative RRT showed comparable overall survival and renal outcome to patients who were free from both pre- and postoperative RRT. In multivariable analysis, preoperative RRT was not associated with progression to ESRD or all-cause mortality after HTx; however, postoperative RRT was a significant predictor for both progression to ESRD and all-cause mortality after HTx. Preoperative creatinine or estimated glomerular filtration rate (eGFR) were not predictive of progression to ESRD after HTx. The present analysis suggests that preoperative RRT requirement does not indicate irreversible renal dysfunction in patients waiting for HTx. However, postoperative RRT was associated with progression to ESRD and mortality after HTx.
- Published
- 2021
16. Effect of Nitric Oxide on Human Corneal Epithelial Cell Viability and Corneal Wound Healing
- Author
-
Minwook Chang, Joo Hee Park, Ja Yeon Kim, Dong Ju Kim, Martha Kim, Choul Yong Park, and Roy S. Chuck
- Subjects
0301 basic medicine ,MAPK/ERK pathway ,Male ,Cell Survival ,Science ,p38 mitogen-activated protein kinases ,Nitric Oxide ,p38 Mitogen-Activated Protein Kinases ,Article ,Proinflammatory cytokine ,Nitric oxide ,Cornea ,03 medical and health sciences ,chemistry.chemical_compound ,Mice ,Cell Movement ,Burns, Chemical ,medicine ,Animals ,Humans ,Phosphorylation ,Extracellular Signal-Regulated MAP Kinases ,Cells, Cultured ,Cell Proliferation ,Mice, Inbred BALB C ,Wound Healing ,Multidisciplinary ,030102 biochemistry & molecular biology ,Kinase ,Epithelium, Corneal ,Epithelial Cells ,Epithelium ,eye diseases ,Cell biology ,Eye Burns ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Immunology ,Medicine ,sense organs ,Wound healing ,Corneal Injuries - Abstract
Although the wound healing effects of nitric oxide (NO) are known, the mechanism by which NO modulates corneal wound healing remains unclear. In this study, we investigated the effect of exogenous NO donor (NaNO2) on corneal wound healing. We found that NaNO2 (0.1 μM to 100 μM) increased human corneal epithelial cell (HCEC) viability and migration. It also modulated the phosphorylation of mitogen-activated protein kinases (MAPKs) in a time- dependent manner in those HCECs. Further, p38 MAPK phosphorylation increased at 6 h and normalized at 24 h, while the phosphorylation of extracellular signal regulated kinase (ERK) was increased both at 6 h and 24 h. Topical treatment with NaNO2 (10 μM) enhanced corneal epithelial healing and decreased corneal opacity in murine corneal alkali burn model by modulating inflammatory cytokines. Our findings suggest that NO increased HCEC proliferation and migration via time-dependent MAPK activation and eventually enhanced corneal recovery from the alkali burn.
- Published
- 2017
17. The Nature of Metastable AA’ Graphite: Low Dimensional Nano- and Single-Crystalline Forms
- Author
-
Bong-Ki Min, Dong Ju Moon, Sang Gil Lee, Y.N. Park, Wooyoung Lee, Jae Kap Lee, K. P. S. S. Hembram, Jeon Kook Lee, Jin Gyu Kim, Phillip John, and Yong-Il Kim
- Subjects
Multidisciplinary ,Materials science ,Graphene ,chemistry.chemical_element ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Article ,law.invention ,Crystallography ,chemistry ,law ,Metastability ,0103 physical sciences ,Nano ,Graphite ,Texture (crystalline) ,010306 general physics ,0210 nano-technology ,Bilayer graphene ,Electronic band structure ,Carbon - Abstract
Over the history of carbon, it is generally acknowledged that Bernal AB stacking of the sp2 carbon layers is the unique crystalline form of graphite. The universal graphite structure is synthesized at 2,600~3,000 °C and exhibits a micro-polycrystalline feature. In this paper, we provide evidence for a metastable form of graphite with an AA’ structure. The non-Bernal AA’ allotrope of graphite is synthesized by the thermal- and plasma-treatment of graphene nanopowders at ~1,500 °C. The formation of AA’ bilayer graphene nuclei facilitates the preferred texture growth and results in single-crystal AA’ graphite in the form of nanoribbons (1D) or microplates (2D) of a few nm in thickness. Kinetically controlled AA’ graphite exhibits unique nano- and single-crystalline feature and shows quasi-linear behavior near the K-point of the electronic band structure resulting in anomalous optical and acoustic phonon behavior.
- Published
- 2016
18. Roll-to-roll slot-die coating of 400 mm wide, flexible, transparent Ag nanowire films for flexible touch screen panels
- Author
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Ki-Hyun Kim, Dong-Ju Kim, Eun-Hye Ko, Han-Ki Kim, Tae-Woong Kim, and Hae-In Shin
- Subjects
Multidisciplinary ,Materials science ,Fabrication ,business.industry ,Nanowire ,02 engineering and technology ,engineering.material ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Die (integrated circuit) ,Article ,0104 chemical sciences ,Roll-to-roll processing ,Coating ,Electrode ,engineering ,Optoelectronics ,0210 nano-technology ,business ,Layer (electronics) ,Sheet resistance - Abstract
We report fabrication of large area Ag nanowire (NW) film coated using a continuous roll-to-roll (RTR) slot die coater as a viable alternative to conventional ITO electrodes for cost-effective and large-area flexible touch screen panels (TSPs). By controlling the flow rate of shear-thinning Ag NW ink in the slot die, we fabricated Ag NW percolating network films with different sheet resistances (30–70 Ohm/square), optical transmittance values (89–90%), and haze (0.5–1%) percentages. Outer/inner bending, twisting, and rolling tests as well as dynamic fatigue tests demonstrated that the mechanical flexibility of the slot-die coated Ag NW films was superior to that of conventional ITO films. Using diamond-shape patterned Ag NW layer electrodes (50 Ohm/square, 90% optical transmittance), we fabricated 12-inch flexible film-film type and rigid glass-film-film type TSPs. Successful operation of flexible TSPs with Ag NW electrodes indicates that slot-die-coated large-area Ag NW films are promising low cost, high performance, and flexible transparent electrodes for cost-effective large-area flexible TSPs and can be substituted for ITO films, which have high sheet resistance and are brittle.
- Published
- 2016
19. Novel synthetic (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol inhibits arthritis by targeting signal transducer and activator of transcription 3
- Author
-
Sang-Bae Han, Mi Hee Park, Benjamin Gann, Seong-Su Nah, Dae Hwan Kim, Young Wan Ham, Yu Yeon Jung, Kevin X. Rodriguez, Dong Ju Son, Scott R. Burt, Hee Pom Lee, Udumula Venkatareddy, and Jin Tae Hong
- Subjects
0301 basic medicine ,Male ,STAT3 Transcription Factor ,Arthritis ,Article ,Arthritis, Rheumatoid ,03 medical and health sciences ,Mice ,Phenols ,In vivo ,medicine ,Animals ,Humans ,STAT3 ,Aged ,Autoimmune disease ,Aged, 80 and over ,Multidisciplinary ,biology ,Chemistry ,Middle Aged ,medicine.disease ,Small molecule ,Molecular biology ,Arthritis, Experimental ,Synoviocytes ,In vitro ,030104 developmental biology ,RAW 264.7 Cells ,Gene Expression Regulation ,Rheumatoid arthritis ,biology.protein ,STAT protein ,Female ,Signal Transduction - Abstract
Rheumatoid arthritis (RA) is a severely debilitating chronic autoimmune disease that leads to long-term joint damage. Signal transducer and activator of transcription 3 (STAT3)-targeted small molecules have shown promise as therapeutic drugs for treating RA. We previously identified (E)-2,4-bis(p-hydroxyphenyl)-2-butenal (BHPB), a tyrosine-fructose Maillard reaction product, as a small molecule with potent anti-inflammatory and anti-arthritic properties, mediated through the inhibition of STAT3 activation. The aim of this study was to develop a novel BHPH derivative with improved anti-arthritic properties and drug-likeness. We designed and synthesised (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol (MMPP), a novel synthetic BHPB analogue, and investigated its anti-inflammatory and anti-arthritic activities in experimentally-induced RA. We showed that MMPP strongly inhibited pro-inflammatory responses by inhibiting in vitro STAT3 activation and its downstream signalling in murine macrophages and human synoviocytes from patients with RA. Furthermore, we demonstrated that MMPP exhibited potent anti-arthritic activity in a collagen antibody-induced arthritis (CAIA) mouse model in vivo. Collectively, our results suggest that MMPP has great potential for use in the treatment of RA.
- Published
- 2016
20. Effect of Nitric Oxide on Human Corneal Epithelial Cell Viability and Corneal Wound Healing
- Author
-
Park, Joo-Hee, primary, Kim, Ja-Yeon, additional, Kim, Dong Ju, additional, Kim, Martha, additional, Chang, Minwook, additional, Chuck, Roy S., additional, and Park, Choul Yong, additional
- Published
- 2017
- Full Text
- View/download PDF
21. The Nature of Metastable AA’ Graphite: Low Dimensional Nano- and Single-Crystalline Forms
- Author
-
Lee, Jae-Kap, primary, Kim, Jin-Gyu, additional, Hembram, K. P. S. S., additional, Kim, Yong-Il, additional, Min, Bong-Ki, additional, Park, Yeseul, additional, Lee, Jeon-Kook, additional, Moon, Dong Ju, additional, Lee, Wooyoung, additional, Lee, Sang-Gil, additional, and John, Phillip, additional
- Published
- 2016
- Full Text
- View/download PDF
22. Novel synthetic (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol inhibits arthritis by targeting signal transducer and activator of transcription 3
- Author
-
Son, Dong Ju, primary, Kim, Dae Hwan, additional, Nah, Seong-Su, additional, Park, Mi Hee, additional, Lee, Hee Pom, additional, Han, Sang Bae, additional, Venkatareddy, Udumula, additional, Gann, Benjamin, additional, Rodriguez, Kevin, additional, Burt, Scott R., additional, Ham, Young Wan, additional, Jung, Yu Yeon, additional, and Hong, Jin Tae, additional
- Published
- 2016
- Full Text
- View/download PDF
23. Indium-free, highly transparent, flexible Cu2O/Cu/Cu2O mesh electrodes for flexible touch screen panels
- Author
-
Dong-Ju Kim, Han-Ki Kim, Ki-Won Seo, Ki-Hyun Kim, Hyo-Joong Kim, and Tae-Wong Kim
- Subjects
Multidisciplinary ,Materials science ,business.industry ,chemistry.chemical_element ,Optical transmittance ,Bending ,Article ,chemistry ,Sputtering ,Electrical resistivity and conductivity ,Electrode ,Optoelectronics ,business ,Indium ,Sheet resistance - Abstract
We report on an indium-free and cost-effective Cu2O/Cu/Cu2O multilayer mesh electrode grown by room temperature roll-to-roll sputtering as a viable alternative to ITO electrodes for the cost-effective production of large-area flexible touch screen panels (TSPs). By using a low resistivity metallic Cu interlayer and a patterned mesh structure, we obtained Cu2O/Cu/Cu2O multilayer mesh electrodes with a low sheet resistance of 15.1 Ohm/square and high optical transmittance of 89% as well as good mechanical flexibility. Outer/inner bending test results showed that the Cu2O/Cu/Cu2O mesh electrode had a mechanical flexibility superior to that of conventional ITO films. Using the diamond-patterned Cu2O/Cu/Cu2O multilayer mesh electrodes, we successfully demonstrated TSPS of the flexible film-film type and rigid glass-film-film type TSPs. The TSPs with Cu2O/Cu/Cu2O mesh electrode were used to perform zoom in/out functions and multi-touch writing, indicating that these electrodes are promising cost-efficient transparent electrodes to substitute for conventional ITO electrodes in large-area flexible TSPs.
- Published
- 2015
24. Roll-to-roll slot-die coating of 400 mm wide, flexible, transparent Ag nanowire films for flexible touch screen panels
- Author
-
Kim, Dong-Ju, primary, Shin, Hae-In, additional, Ko, Eun-Hye, additional, Kim, Ki-Hyun, additional, Kim, Tae-Woong, additional, and Kim, Han-Ki, additional
- Published
- 2016
- Full Text
- View/download PDF
25. Piperlongumine inhibits lung tumor growth via inhibition of nuclear factor kappa B signaling pathway
- Author
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Zheng, Jie, primary, Son, Dong Ju, additional, Gu, Sun Mi, additional, Woo, Ju Rang, additional, Ham, Young Wan, additional, Lee, Hee Pom, additional, Kim, Wun Jae, additional, Jung, Jae Kyung, additional, and Hong, Jin Tae, additional
- Published
- 2016
- Full Text
- View/download PDF
26. Indium-free, highly transparent, flexible Cu2O/Cu/Cu2O mesh electrodes for flexible touch screen panels
- Author
-
Kim, Dong-Ju, primary, Kim, Hyo-Joong, additional, Seo, Ki-Won, additional, Kim, Ki-Hyun, additional, Kim, Tae-Wong, additional, and Kim, Han-Ki, additional
- Published
- 2015
- Full Text
- View/download PDF
27. Indium-free, highly transparent, flexible Cu2O/Cu/Cu2O mesh electrodes for flexible touch screen panels.
- Author
-
Kim, Dong-Ju, Kim, Hyo-Joong, Seo, Ki-Won, Kim, Han-Ki, Kim, Ki-Hyun, and Kim, Tae-Wong
- Subjects
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INDIUM tin oxide , *TOUCH screens , *CARBON nanotubes , *TRANSMITTANCE (Physics) , *ELECTRODES - Abstract
We report on an indium-free and cost-effective Cu2O/Cu/Cu2O multilayer mesh electrode grown by room temperature roll-to-roll sputtering as a viable alternative to ITO electrodes for the cost-effective production of large-area flexible touch screen panels (TSPs). By using a low resistivity metallic Cu interlayer and a patterned mesh structure, we obtained Cu2O/Cu/Cu2O multilayer mesh electrodes with a low sheet resistance of 15.1 Ohm/square and high optical transmittance of 89% as well as good mechanical flexibility. Outer/inner bending test results showed that the Cu2O/Cu/Cu2O mesh electrode had a mechanical flexibility superior to that of conventional ITO films. Using the diamond-patterned Cu2O/Cu/Cu2O multilayer mesh electrodes, we successfully demonstrated TSPS of the flexible film-film type and rigid glass-film-film type TSPs. The TSPs with Cu2O/Cu/Cu2O mesh electrode were used to perform zoom in/out functions and multi-touch writing, indicating that these electrodes are promising cost-efficient transparent electrodes to substitute for conventional ITO electrodes in large-area flexible TSPs. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
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