1. Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus product
- Author
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Lourdes Ibáñez, Abel López-Bermejo, Anna Prats-Puig, Núria Espuña-Capote, Judit Bassols, Francis de Zegher, Mercè Montesinos-Costa, Silvia Xargay-Torrent, Gemma Carreras-Badosa, and Ferran Diaz-Roldan
- Subjects
0301 basic medicine ,Serum ,medicine.medical_specialty ,Waist ,Risk factors in diseases ,Cross-sectional study ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Gastroenterology ,Carotid Intima-Media Thickness ,Risk Assessment ,Article ,03 medical and health sciences ,0302 clinical medicine ,Insulin resistance ,Internal medicine ,medicine ,Humans ,Child ,lcsh:Science ,Multidisciplinary ,Malalties cardiovasculars ,Factors de risc en les malalties ,business.industry ,Confounding ,lcsh:R ,Malalties dels infants ,Phosphorus ,medicine.disease ,Alkaline Phosphatase ,Atherosclerosis ,Children's diseases ,Cardiovascular diseases ,030104 developmental biology ,Blood pressure ,Cross-Sectional Studies ,Homeostatic model assessment ,Alkaline phosphatase ,High calcium ,Calcium ,lcsh:Q ,business ,Blood Chemical Analysis - Abstract
Although alkaline phosphatase (ALP) correlates with cardiovascular risk in adults, there are no studies in children. We evaluated the association between serum ALP levels, calcium-phosphorus product (Ca*P) and cardiovascular risk markers in healthy children. Children aged 7.9 ± 1.4 (n = 379) were recruited in this cross-sectional study. The main outcome measures were systolic and diastolic blood pressure (SBP and DBP) and carotid intima-media thickness (cIMT). Additional assessments were body-mass index (BMI), waist circumference, homeostatic model assessment of insulin resistance (HOMA-IR) and fasting lipids, ALP, serum calcium, phosphorus and Ca*P. ALP was directly correlated with BMI (p p p p = 0.005), HOMA-IR (p p = 0.0001). Among them, in children with Ca*P values above the median the associations were BMI (r = 0.231; p = 0.001), waist (r = 0.252; p p p p p = 0.013) in children with higher Ca*P, after adjusting for confounding variables. Circulating ALP is associated with a more adverse cardiovascular profile in children with higher Ca*P. We suggest that serum ALP and Ca*P levels could contribute to the assessment of risk for cardiovascular disease in children.
- Published
- 2018
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