1. Levels of Systemic Low-grade Inflammation in Pregnant Mothers and Their Offspring are Correlated.
- Author
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Fink NR, Chawes B, Bønnelykke K, Thorsen J, Stokholm J, Rasmussen MA, Brix S, and Bisgaard H
- Subjects
- Asthma blood, Asthma epidemiology, Biomarkers blood, C-Reactive Protein immunology, Female, Humans, Infant, Inflammation blood, Male, Mothers, Pregnancy, Pregnancy Trimester, Second blood, Prenatal Exposure Delayed Effects blood, Prenatal Exposure Delayed Effects epidemiology, Prospective Studies, Risk Factors, Asthma immunology, C-Reactive Protein analysis, Inflammation immunology, Pregnancy Trimester, Second immunology, Prenatal Exposure Delayed Effects immunology
- Abstract
High sensitivity C-reactive protein (hs-CRP) is a marker of systemic low-grade inflammation and associated with chronic inflammatory diseases. It is unknown whether maternal and infant hs-CRP levels are correlated and little is known about risk factors in early childhood. Hs-CRP were measured in mothers during pregnancy week 24 (N = 690), and one-week postpartum (N = 675) and in their children age 6 mo (N = 640) enrolled in the Copenhagen Prospective Studies on Asthma in Childhood
2010 (COPSAC2010 ) cohort. The risk factor analysis included anthropometrics, environmental exposures and CRP-Genetic Risk Score (GRS). Mother's body mass index (BMI), use of antibiotics, smoking, cesarean delivery and season were associated with higher maternal hs-CRP level, whereas higher social circumstances were associated with lower hs-CRP level (p < 0.05). Child's BMI, siblings, bacterial airway colonization, current infection, CRP-genetic risk score and season were associated with higher hs-CRP at age 6 mo (all p < 0.05). Mother's hs-CRP level in pregnancy week 24 was associated with hs-CRP level in the child at 6 mo: β-coefficient = 0.11 [95% CI: 0.01-0.20], R2 = 0.22, p = 0.03. The association was unchanged adjusted for all significant risk factors. Systemic low-grade inflammation in pregnant mothers and their offspring is correlated independently of BMI, environmental exposures and genetic risk factors.- Published
- 2019
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