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The imine base and Cu2+ precursors were combined using magnetic stirring to formulate the Cu2+ complexes. The formation of the imine base was confirmed by electronic and vibrational spectra, proton NMR, LC-mass spectrometry, and computational studies, which also optimized the final structure. The Cu2+ complexes were characterized using electronic and vibrational spectra, magnetic susceptibility, molar conductivity, a variable temperature magnetometer, and ESR spectroscopy. Cyclic voltammetry revealed electron transfer from Cu2+ to Cu+ within the complex. The in vitro tumour activity of the Cu2+ complexes and imine base were evaluated on the A431 cell line using the MTT assay. DFT studies validated the structural stability of the imine base. The antiferromagnetic behaviour observed at low temperatures suggests that these Cu2+ complexes could be useful in heavy magnetic materials. Due to their electron transfer properties, Cu2+ complexes also hold potential for use in electroplating systems and sensors. The complexes exhibited high efficacy on the cell line, aligning with clinical objectives. The Cu2+ complexes are represented as [MLR], where M is the metal, L is the imine base, and R = [C₆H₅COO] or R = [C₆H₄COO(NH₂)]. [ABSTRACT FROM AUTHOR]

Abstract We report on the development of a nonlinear optical microscopic technique based on two-photon absorption induced photothermal effect capable of detecting individual nonfluorescent nanoparticles with high sensitivity. The method which is inherently confocal makes use of near infrared excitation at high repetition rates and would be of interest in deep tissue imaging. We demonstrate the applicability of the technique by imaging single BaTiO3 nanoparticles, a potential biomolecular label having high photostability, in a scattering environment at fast time scales with a pixel dwell time of 80 μs.