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17 results on '"Han JU"'

12. SWATH-MS-based quantitative proteomics reveals a uniquely intricate defense response in Cnaphalocrocis medinalis-resistant rice

Author

Chien-Chen Lai, Wen-Po Chuang, Hou-Ho Lin, Boon Huat Cheah, Han-Ju Chien, Ya-Fen Lin, Li-Yu Daisy Liu, and Chung-Ta Liao

Subjects
0301 basic medicine, Chalcone synthase, Proteome, Plant molecular biology, Lipoxygenase, lcsh:Medicine, Phenylalanine ammonia-lyase, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Secondary metabolic process, Animals, lcsh:Science, Biotic, Amino acid synthesis, Disease Resistance, Phenylalanine Ammonia-Lyase, Plant Proteins, chemistry.chemical_classification, Multidisciplinary, biology, Jasmonic acid, lcsh:R, food and beverages, Oryza, biology.organism_classification, Cnaphalocrocis medinalis, Lepidoptera, 030104 developmental biology, Flavonoid biosynthesis, chemistry, Biochemistry, Plant protein, biology.protein, lcsh:Q, 030217 neurology & neurosurgery, Acyltransferases
Abstract

Cnaphalocrocis medinalis is a major insect pest of rice in Asia. A few defensive enzymes were reported to show higher activities in a resistant rice line (Qingliu) than in a susceptible rice line (TN1) upon leaffolder infestation. However, the overall molecular regulation of the rice defense response against leaffolder herbivory is unknown. Here, differential proteomic analysis by SWATH-MS was performed to identify differentially expressed proteins between the two rice varieties, Qingliu and TN1, at four time points of leaffolder herbivory, 0, 6, 24, and 72 h. Gene Ontology (GO) enrichment of the differentially expressed proteins indicated overrepresentation of (1) photosynthesis, (2) amino acid and derivative metabolic process, and (3) secondary metabolic process. Phenylalanine ammonia lyase and chalcone synthase, which catalyze flavonoid biosynthesis, and lipoxygenase, which catalyzes jasmonic acid biosynthesis, exhibited higher expression in Qingliu than in TN1 even before insect herbivory. Momentary activation of the light reaction and Calvin cycle was detected in Qingliu at 6 h and 24 h of insect herbivory, respectively. At 72 h of insect herbivory, amino acid biosynthesis and glutathione-mediated antioxidation were activated in Qingliu. A defense response involving jasmonic acid signaling, carbon remobilization, and the production of flavonoids and glutathione could underlie the resistance of Qingliu to leaffolder.

Published
2019

14. Improved efficacy and in vivo cellular properties of human embryonic stem cell derivative in a preclinical model of bladder pain syndrome

Author

Kim, Aram, primary, Yu, Hwan Yeul, additional, Lim, Jisun, additional, Ryu, Chae-Min, additional, Kim, Yong Hwan, additional, Heo, Jinbeom, additional, Han, Ju-Young, additional, Lee, Seungun, additional, Bae, Yoon Sung, additional, Kim, Jae Young, additional, Bae, Dong-Jun, additional, Kim, Sang-Yeob, additional, Noh, Byeong-Joo, additional, Hong, Ki-Sung, additional, Han, Ji-Yeon, additional, Lee, Sang Wook, additional, Song, Miho, additional, Chung, Hyung-Min, additional, Kim, Jun Ki, additional, Shin, Dong-Myung, additional, and Choo, Myung-Soo, additional

Published
2017
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17. Bax Inhibitor-1 regulates hepatic lipid accumulation via ApoB secretion

Author

Hwa Young Lee, Geum-Hwa Lee, Kashi Raj Bhattarai, Byung-Hyun Park, Seung-Hoi Koo, Hyung-Ryong Kim, and Han Jung Chae

Subjects
Medicine, Science
Abstract

Abstract In this study, we explored the effects of Bax Inhibitor-1 (BI-1) on ApoB aggregation in high-fat diet (HFD)-induced hepatic lipid accumulation. After 1 week on a HFD, triglycerides and cholesterol accumulated more in the liver and were not effectively secreted into the plasma, whereas after 8 weeks, lipids were highly accumulated in both the liver and plasma, with a greater effect in BI-1 KO mice compared with BI-1 WT mice. ApoB, a lipid transfer protein, was accumulated to a greater extent in the livers of HFD-BI-1 KO mice compared with HFD-BI-1 WT mice. Excessive post-translational oxidation of protein disulfide isomerase (PDI), intra-ER ROS accumulation and folding capacitance alteration were also observed in HFD-BI-1 KO mice. Higher levels of endoplasmic reticulum (ER) stress were consistently observed in KO mice compared with the WT mice. Adenovirus-mediated hepatic expression of BI-1 in the BI-1 KO mice rescued the above phenotypes. Our results suggest that BI-1-mediated enhancement of ApoB secretion regulates hepatic lipid accumulation, likely through regulation of ER stress and ROS accumulation.

Published
2016
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