1. Baseline T-lymphocyte subset absolute counts can predict both outcome and severity in SARS-CoV-2 infected patients: a single center study
- Author
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Marco Iannetta, Francesco Buccisano, Daniela Fraboni, Vincenzo Malagnino, Laura Campogiani, Elisabetta Teti, Ilaria Spalliera, Benedetta Rossi, Andrea Di Lorenzo, Raffaele Palmieri, Angela Crea, Marta Zordan, Pietro Vitale, Maria Teresa Voso, Massimo Andreoni, and Loredana Sarmati
- Subjects
Medicine ,Science - Abstract
Abstract The aim of this study was to evaluate the role of baseline lymphocyte subset counts in predicting the outcome and severity of COVID-19 patients. Hospitalized patients confirmed to be infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were included and classified according to in-hospital mortality (survivors/nonsurvivors) and the maximal oxygen support/ventilation supply required (nonsevere/severe). Demographics, clinical and laboratory data, and peripheral blood lymphocyte subsets were retrospectively analyzed. Overall, 160 patients were retrospectively included in the study. T-lymphocyte subset (total CD3+, CD3+ CD4+, CD3+ CD8+, CD3+ CD4+ CD8+ double positive [DP] and CD3+ CD4− CD8− double negative [DN]) absolute counts were decreased in nonsurvivors and in patients with severe disease compared to survivors and nonsevere patients (p
- Published
- 2021
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