Search

Rapid outbreak of coronavirus disease 2019 (Covid-19) raised major concern regarding medical resource constraints. We constructed and validated a scoring system for early prediction of progression to severe pneumonia in patients with Covid-19. A total of 561 patients from a Covid-19 designated hospital in Daegu, South Korea were randomly divided into two cohorts: development cohort (N = 421) and validation cohort (N = 140). We used multivariate logistic regression to identify four independent risk predictors for progression to severe pneumonia and constructed a risk scoring system by giving each factor a number of scores corresponding to its regression coefficient. We calculated risk scores for each patient and defined two groups: low risk (0 to 8 points) and high risk (9 to 20 points). In the development cohort, the sensitivity and specificity were 83.8% and 78.9%. In the validation cohort, the sensitivity and specificity were 70.8% and 79.3%, respectively. The C-statistics was 0.884 (95% CI 0.833-0.934) in the development cohort and 0.828 (95% CI 0.733-0.923) in the validation cohort. This risk scoring system is useful to identify high-risk group for progression to severe pneumonia in Covid-19 patients and can prevent unnecessary overuse of medical care in limited-resource settings., (© 2022. The Author(s).)

The phase noise of microwaves extracted from optical frequency combs is fundamentally limited by thermal and shot noise, which is inherent in photodetection. Saturation of a photodiode due to the high peak power of ultrashort optical pulses, however, prohibits further scaling of white phase noise by increasing incident optical power. Here we demonstrate that the photocurrent pulse shaping via balanced photodetection, which is accomplished by replacing a single photodiode with a balanced photodetector (BPD) and delaying one of the optical pulses, provides a simple and efficient optical-to-electrical interface to increase achievable microwave power and reduces the corresponding thermal noise-limited phase noise by 6-dB. By analysing contributing noise sources, we also show that the thermal noise floor can reach - 166 dBc/Hz even at a low photocurrent of 2-mA (4-mW optical input per photodiode) when using a p-i-n BPD. This finding may be useful for on-chip microwave generation, which consists of standard p-i-n structure photodiodes with relatively low saturation optical power., (© 2021. The Author(s).)

Animals change feeding behavior depending on their metabolic status; starved animals are eager to eat and satiated animals stop eating. C. elegans exhibits satiety quiescence under certain conditions that mimics many aspects of post-prandial sleep in mammals. Here we show that this feeding behavior depends on fat metabolism mediated by the SREBP-SCD pathway, an acetyl-CoA carboxylase (ACC) and certain nuclear hormone receptors (NRs). Mutations of the genes in the SREBP-SCD pathway reduce satiety quiescence. An RNA interference (RNAi) screen of the genes that regulate glucose and fatty acid metabolism identified an ACC necessary for satiety quiescence in C. elegans. ACC catalyzes the first step in de novo fatty acid biosynthesis known to be downstream of the SREBP pathway in mammals. We identified 28 NRs by microarray whose expression changes during refeeding after being starved. When individually knocked down by RNAi, 11 NRs among 28 affect both fat storage and satiety behavior. Our results show that the major fat metabolism pathway regulates feeding behavior and NRs could be the mediators to link the feeding behavior to the metabolic changes.