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2 results on '"Michael O. Kusimo"'

1. Temporal escalation of Pyrethroid Resistance in the major malaria vector Anopheles coluzzii from Sahelo-Sudanian Region of northern Nigeria

Author

Sulaiman S. Ibrahim, Muhammad M. Mukhtar, Jamila A. Datti, Helen Irving, Michael O. Kusimo, Williams Tchapga, Nura Lawal, Fatima I. Sambo, and Charles S. Wondji

Subjects
parasitic diseases, lcsh:R, lcsh:Medicine, lcsh:Q, lcsh:Science
Abstract

Despite the highest global burden of malaria, information on bionomics and insecticide resistance status of malaria vectors is grossly lacking in the densely populated Sahelo-Sudanian region of Nigeria. To support evidence-based vector control we characterised transmission and resistance profiles of Anopheles coluzzii populations from three sites in northern Nigeria. High sporozoite infection (~19.51%) was found in the An. coluzzii populations. A high pyrethroid resistance was observed with only 1% mortality against deltamethrin, a high LD50 (96.57 µg/ml), and a high LT50 (170.27 min, resistance ratio of ~51 compared with the fully susceptible Ngoussou colony). Moderate carbamate resistance was observed. Synergist bioassays significantly recovered deltamethrin susceptibility implicating CYP450s (mortality = 85%, χ2 = 134.04, p

Published
2019
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2. Temporal escalation of Pyrethroid Resistance in the major malaria vector Anopheles coluzzii from Sahelo-Sudanian Region of northern Nigeria

Author

Sulaiman S, Ibrahim, Muhammad M, Mukhtar, Jamila A, Datti, Helen, Irving, Michael O, Kusimo, Williams, Tchapga, Nura, Lawal, Fatima I, Sambo, and Charles S, Wondji

Subjects
Male, Insecticides, Plasmodium, Mosquito Control, Nigeria, Genes, Insect, Exons, Mosquito Vectors, Voltage-Gated Sodium Channels, DNA, Article, Malaria, Insecticide Resistance, Lethal Dose 50, Sporozoites, parasitic diseases, Anopheles, Mutation, Nitriles, Pyrethrins, Animals, Humans, Insect Proteins, Biological Assay, Female
Abstract

Despite the highest global burden of malaria, information on bionomics and insecticide resistance status of malaria vectors is grossly lacking in the densely populated Sahelo-Sudanian region of Nigeria. To support evidence-based vector control we characterised transmission and resistance profiles of Anopheles coluzzii populations from three sites in northern Nigeria. High sporozoite infection (~19.51%) was found in the An. coluzzii populations. A high pyrethroid resistance was observed with only 1% mortality against deltamethrin, a high LD50 (96.57 µg/ml), and a high LT50 (170.27 min, resistance ratio of ~51 compared with the fully susceptible Ngoussou colony). Moderate carbamate resistance was observed. Synergist bioassays significantly recovered deltamethrin susceptibility implicating CYP450s (mortality = 85%, χ2 = 134.04, p

Published
2019

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