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Start Over Author "Palmieri, Camillo" Journal scientific reports
5 results on '"Palmieri, Camillo"'

2. A polymorphism of HMGA1 protects against proliferative diabetic retinopathy by impairing HMGA1-induced VEGFA expression

Author

Chiefari, Eusebio, primary, Ventura, Valeria, additional, Capula, Carmelo, additional, Randazzo, Giorgio, additional, Scorcia, Vincenzo, additional, Fedele, Monica, additional, Arcidiacono, Biagio, additional, Nevolo, Maria Teresa, additional, Bilotta, Francesco Luciano, additional, Vitiello, Michela, additional, Palmieri, Camillo, additional, Gulletta, Elio, additional, Fusco, Alfredo, additional, Foti, Daniela, additional, Vero, Raffaella, additional, and Brunetti, Antonio, additional

Published
2016
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3. Impairment of T cell development and acute inflammatory response in HIV-1 Tat transgenic mice

Author

Fiume, Giuseppe, primary, Scialdone, Annarita, additional, Albano, Francesco, additional, Rossi, Annalisa, additional, Maria Tuccillo, Franca, additional, Rea, Domenica, additional, Palmieri, Camillo, additional, Caiazzo, Elisabetta, additional, Cicala, Carla, additional, Bellevicine, Claudio, additional, Falcone, Cristina, additional, Vecchio, Eleonora, additional, Pisano, Antonio, additional, Ceglia, Simona, additional, Mimmi, Selena, additional, Iaccino, Enrico, additional, Laurentiis, Annamaria de, additional, Pontoriero, Marilena, additional, Agosti, Valter, additional, Troncone, Giancarlo, additional, Mignogna, Chiara, additional, Palma, Giuseppe, additional, Arra, Claudio, additional, Mallardo, Massimo, additional, Maria Buonaguro, Franco, additional, Scala, Giuseppe, additional, and Quinto, Ileana, additional

Published
2015
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4. HMGA1 is a novel downstream nuclear target of the insulin receptor signaling pathway

Author

Chiefari, Eusebio, primary, Nevolo, Maria T., additional, Arcidiacono, Biagio, additional, Maurizio, Elisa, additional, Nocera, Aurora, additional, Iiritano, Stefania, additional, Sgarra, Riccardo, additional, Possidente, Katiuscia, additional, Palmieri, Camillo, additional, Paonessa, Francesco, additional, Brunetti, Giuseppe, additional, Manfioletti, Guidalberto, additional, Foti, Daniela, additional, and Brunetti, Antonio, additional

Published
2012
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5. Impairment of T cell development and acute inflammatory response in HIV-1 Tat transgenic mice

Author

Giancarlo Troncone, F. Tuccillo, Massimo Mallardo, Simona Ceglia, Enrico Iaccino, Selena Mimmi, Franco M. Buonaguro, Giuseppe Palma, Antonio Pisano, Ileana Quinto, Valter Agosti, Cristina Falcone, Eleonora Vecchio, Marilena Pontoriero, Annarita Scialdone, Domenica Rea, Annalisa Rossi, Camillo Palmieri, Elisabetta Caiazzo, Annamaria de Laurentiis, Francesco Albano, Claudio Bellevicine, Claudio Arra, Giuseppe Scala, Carla Cicala, Chiara Mignogna, Giuseppe Fiume, Fiume, Giuseppe, Scialdone, Annarita, Albano, Francesco, Rossi, Annalisa, Tuccillo, Franca Maria, Rea, Domenica, Palmieri, Camillo, Caiazzo, Elisabetta, Cicala, Carla, Bellevicine, Claudio, Falcone, Cristina, Vecchio, Eleonora, Pisano, Antonio, Ceglia, Simona, Mimmi, Selena, Iaccino, Enrico, de Laurentiis, Annamaria, Pontoriero, Marilena, Agosti, Valter, Troncone, Giancarlo, Mignogna, Chiara, Palma, Giuseppe, Arra, Claudio, Mallardo, Massimo, Buonaguro, Franco Maria, Scala, Giuseppe, and Quinto, Ileana

Subjects
Lipopolysaccharides, Genetically modified mouse, Chemokine, T cell, Gene Expression, HIV Infections, Mice, Transgenic, Inflammation, Thymus Gland, Biology, Article, Lymphocyte Depletion, Proinflammatory cytokine, Mice, Immune system, T-Lymphocyte Subsets, medicine, Animals, Cluster Analysis, Lymphocyte Count, Lymphopoiesis, Thymocytes, Multidisciplinary, Gene Expression Profiling, NF-kappa B, Cell Differentiation, MicroRNAs, medicine.anatomical_structure, Immunology, HIV-1, biology.protein, Cytokines, tat Gene Products, Human Immunodeficiency Virus, medicine.symptom, CD8
Abstract

Immune activation and chronic inflammation are hallmark features of HIV infection causing T-cell depletion and cellular immune dysfunction in AIDS. Here, we addressed the issue whether HIV-1 Tat could affect T cell development and acute inflammatory response by generating a transgenic mouse expressing Tat in lymphoid tissue. Tat-Tg mice showed thymus atrophy and the maturation block from DN4 to DP thymic subpopulations, resulting in CD4+ and CD8+ T cells depletion in peripheral blood. In Tat-positive thymus, we observed the increased p65/NF-κB activity and deregulated expression of cytokines/chemokines and microRNA-181a-1, which are involved in T-lymphopoiesis. Upon LPS intraperitoneal injection, Tat-Tg mice developed an abnormal acute inflammatory response, which was characterized by enhanced lethality and production of inflammatory cytokines. Based on these findings, Tat-Tg mouse could represent an animal model for testing adjunctive therapies of HIV-1-associated inflammation and immune deregulation.

Published
2015

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