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3 results on '"Pineda-Peña, Andrea-Clemencia"'

2. HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier: A Densely Sampled Transmission Dynamics Analysis from 1986 to 2012

Author

Pineda-Peña, Andrea-Clemencia, Theys, Kristof, Stylianou, Dora C., Demetriades, Ioannis, Puchhammer, Elisabeth, Vandamme, Anne-Mieke, Aleksiev, Ivailo, Zidovec Lepej, Snjezana, Linka, Marek, Fonage, Jannik, Liitsola, Kirsi, Kaiser, Rolf, Hamouda, Osamah, Paraskevis, Dimitrios, Coughlan, Suzie, Grossman, Zehava, Mor, Orna, Zazzi, Maurizio, Griskevicius, Algirdas, Lipnickiene, Vilnele, Devaux, Carole, Boucher, Charles, Hofstra, Marije, Wensing, Annemarie, Bakken-Kran, Anne-Marte, Horban, Andrzej, Camacho, Ricardo, Paraschiv, Simona, Otelea, Dan, Stanojevic, Maja, Stanekova, Danika, Poljak, Mario, Garcia, Federico, Paredes, Roger, Albert, Jan, Abecasis, Ana, Kostrikis, Leondios G., Virology, Kostrikis, Leondios G. [0000-0002-5340-7109], Stylianou, Dora C. [0000-0003-4167-1380], Vandamme, Anne-Mieke, and Camacho, Ricardo

Subjects
0301 basic medicine, Male, Genotyping Techniques, Human immunodeficiency virus (HIV), HIV Infections, medicine.disease_cause, law.invention, 0302 clinical medicine, law, Epidemiology, Prevalence, Cluster Analysis, 030212 general & internal medicine, Ofhivinfected Individuals, Molecular Epidemiology, Multidisciplinary, Infectious, virus diseases, Middle Aged, Infection Cyprus, Subtyping, 3. Good health, Transmission (mechanics), Geography, Cohort, Síndromes de inmunodeficiencia, Medicine, Female, Adult, medicine.medical_specialty, Science, Sida, Disease cluster, Article, 03 medical and health sciences, Frontier, Young Adult, Disease Transmission, SDG 3 - Good Health and Well-being, Environmental health, medicine, Disease Transmission, Infectious, Humans, Cyprus, HIV-1, VIH, Enfermedades, Eastern mediterranean, 030104 developmental biology
Abstract

Since HIV-1 treatment is increasingly considered an effective preventionstrategy, it is important to study local HIV-1 epidemics to formulate tailored preventionpolicies. The prevalence of HIV-1 in Cyprus was historically low until 2005. To investigatethe shift in epidemiological trends, we studied the transmission dynamics of HIV-1 in Cyprususing a densely sampled Cypriot HIV-1 transmission cohort that included 85 percent ofHIV-1-infected individuals linked to clinical care between 1986 and 2012 based on detailedclinical, epidemiological, behavioral and HIV-1 genetic information. Subtyping andtransmission cluster reconstruction were performed using maximum likelihood and Bayesianmethods, and the transmission chain network was linked to the clinical, epidemiological andbehavioral data. The results reveal that for the main HIV-1 subtype A1 and B sub-epidemics,young and drug-naïve HIV-1-infected individuals in Cyprus are driving the dynamics of thelocal HIV-1 epidemic. The results of this study provide a better understanding of thedynamics of the HIV-1 infection in Cyprus, which may impact the development of preventionstrategies. Furthermore, this methodology for analyzing densely sampled transmissiondynamics is applicable to other geographic regions to implement effective HIV-1 preventionstrategies in local settings. ispartof: Scientific Reports vol:8 issue:1 ispartof: location:England status: Published online

Published
2017

3. HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier: A Densely Sampled Transmission Dynamics Analysis from 1986 to 2012.

Author

Pineda-Peña AC, Theys K, Stylianou DC, Demetriades I, Abecasis AB, and Kostrikis LG

Subjects
Adult, Cluster Analysis, Cyprus epidemiology, Female, Genotyping Techniques, HIV-1 classification, HIV-1 genetics, Humans, Male, Middle Aged, Molecular Epidemiology, Prevalence, Young Adult, Disease Transmission, Infectious, HIV Infections epidemiology, HIV Infections transmission, HIV-1 isolation & purification
Abstract

Since HIV-1 treatment is increasingly considered an effective preventionstrategy, it is important to study local HIV-1 epidemics to formulate tailored preventionpolicies. The prevalence of HIV-1 in Cyprus was historically low until 2005. To investigatethe shift in epidemiological trends, we studied the transmission dynamics of HIV-1 in Cyprususing a densely sampled Cypriot HIV-1 transmission cohort that included 85 percent ofHIV-1-infected individuals linked to clinical care between 1986 and 2012 based on detailedclinical, epidemiological, behavioral and HIV-1 genetic information. Subtyping andtransmission cluster reconstruction were performed using maximum likelihood and Bayesianmethods, and the transmission chain network was linked to the clinical, epidemiological andbehavioral data. The results reveal that for the main HIV-1 subtype A1 and B sub-epidemics,young and drug-naïve HIV-1-infected individuals in Cyprus are driving the dynamics of thelocal HIV-1 epidemic. The results of this study provide a better understanding of thedynamics of the HIV-1 infection in Cyprus, which may impact the development of preventionstrategies. Furthermore, this methodology for analyzing densely sampled transmissiondynamics is applicable to other geographic regions to implement effective HIV-1 preventionstrategies in local settings.

Published
2018
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